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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2001 1
2002 2
2003 2
2004 9
2005 11
2006 24
2007 36
2008 26
2009 34
2010 44
2011 44
2012 50
2013 46
2014 45
2015 48
2016 54
2017 40
2018 38
2019 40
2020 57
2021 57
2022 25
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651 results
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Role of Toll-like receptors in the pathogenesis of COVID-19.
Khanmohammadi S, Rezaei N. Khanmohammadi S, et al. J Med Virol. 2021 May;93(5):2735-2739. doi: 10.1002/jmv.26826. Epub 2021 Feb 9. J Med Virol. 2021. PMID: 33506952 Free PMC article. Review.
Activation of TLR pathways leads to secretion of pro-inflammatory cytokines, such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha, as well as type 1 interferon. Different TLRs, like TLR2, TLR3, TLR4, TLR6, TLR7, TLR8, and TLR9 are potentially important in CO …
Activation of TLR pathways leads to secretion of pro-inflammatory cytokines, such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor-a …
Infection and atherosclerosis: TLR-dependent pathways.
Li B, Xia Y, Hu B. Li B, et al. Cell Mol Life Sci. 2020 Jul;77(14):2751-2769. doi: 10.1007/s00018-020-03453-7. Epub 2020 Jan 30. Cell Mol Life Sci. 2020. PMID: 32002588 Free PMC article. Review.
TLRs play different roles in different stages of infection of atherosclerosis-related pathogens such as Chlamydia pneumoniae (C. pneumoniae), periodontal pathogens including Porphyromonas gingivalis (P. gingivalis), Helicobacter pylori (H. pylori) and human immunodeficiency vi
TLRs play different roles in different stages of infection of atherosclerosis-related pathogens such as Chlamydia pneumoniae (C. pneumoniae) …
Innate Receptor Activation Patterns Involving TLR and NLR Synergisms in COVID-19, ALI/ARDS and Sepsis Cytokine Storms: A Review and Model Making Novel Predictions and Therapeutic Suggestions.
Root-Bernstein R. Root-Bernstein R. Int J Mol Sci. 2021 Feb 20;22(4):2108. doi: 10.3390/ijms22042108. Int J Mol Sci. 2021. PMID: 33672738 Free PMC article. Review.
This proposition is based on eight linked types of evidence and their logical connections. (1) Severe cases of COVID-19 differ from healthy controls and mild COVID-19 patients in exhibiting increased TLR4, TLR7, TLR9 and NLRP3 activity. (2) SARS-CoV-2 and related coronaviruses ac …
This proposition is based on eight linked types of evidence and their logical connections. (1) Severe cases of COVID-19 differ from healthy …
Whole-Transcriptome RNA Sequencing Reveals Significant Differentially Expressed mRNAs, miRNAs, and lncRNAs and Related Regulating Biological Pathways in the Peripheral Blood of COVID-19 Patients.
Li CX, Chen J, Lv SK, Li JH, Li LL, Hu X. Li CX, et al. Mediators Inflamm. 2021 Apr 1;2021:6635925. doi: 10.1155/2021/6635925. eCollection 2021. Mediators Inflamm. 2021. PMID: 33833618 Free PMC article.
A total of 6 hub genes were selected in the PPI module networks including AKT1, TNFRSF1B, FCGR2A, CXCL8, STAT3, and TLR2. Moreover, a competing endogenous RNA network showed the interactions between lncRNAs, mRNAs, and miRNAs. ...
A total of 6 hub genes were selected in the PPI module networks including AKT1, TNFRSF1B, FCGR2A, CXCL8, STAT3, and TLR2. Moreover, a …
Viral proteins recognized by different TLRs.
Zhou R, Liu L, Wang Y. Zhou R, et al. J Med Virol. 2021 Nov;93(11):6116-6123. doi: 10.1002/jmv.27265. Epub 2021 Aug 17. J Med Virol. 2021. PMID: 34375002 Review.
Virus invasion activates the host's innate immune response, inducing the production of numerous cytokines and interferons to eliminate pathogens. ...These viruses are all enveloped, including respiratory syncytial virus, hepatitis C virus, measles v
Virus invasion activates the host's innate immune response, inducing the production of numerous cytokines and interferons to eliminat
C-type lectins and extracellular vesicles in virus-induced NETosis.
Sung PS, Hsieh SL. Sung PS, et al. J Biomed Sci. 2021 Jun 11;28(1):46. doi: 10.1186/s12929-021-00741-7. J Biomed Sci. 2021. PMID: 34116654 Free PMC article. Review.
The DV-activated EXOs (DV-EXOs) and MVs (DV-MVs) stimulate CLEC5A and Toll-like receptor 2 (TLR2), respectively, to enhance NET formation and inflammatory reactions. Thus, EVs from virus-activated platelets (PLT-EVs) are potent endogenous danger signals, and blockad …
The DV-activated EXOs (DV-EXOs) and MVs (DV-MVs) stimulate CLEC5A and Toll-like receptor 2 (TLR2), respectively, to enhance NET forma …
Intracellular TLRs of Mast Cells in Innate and Acquired Immunity.
Ogawa Y, Kinoshita M, Kawamura T, Shimada S. Ogawa Y, et al. Handb Exp Pharmacol. 2021 Sep 10. doi: 10.1007/164_2021_540. Online ahead of print. Handb Exp Pharmacol. 2021. PMID: 34505203
Synthetic ligands for intracellular TLRs and some viruses are sensed by intracellular TLRs of MCs, leading to the production of inflammatory cytokines and chemokines including type I interferons. ...In this overview, the expression of intracellular TLRs in MCs and the reco …
Synthetic ligands for intracellular TLRs and some viruses are sensed by intracellular TLRs of MCs, leading to the production of infla …
Cytotoxic T-lymphocyte elicited vaccine against SARS-CoV-2 employing immunoinformatics framework.
Kumar N, Admane N, Kumari A, Sood D, Grover S, Prajapati VK, Chandra R, Grover A. Kumar N, et al. Sci Rep. 2021 Apr 7;11(1):7653. doi: 10.1038/s41598-021-86986-6. Sci Rep. 2021. PMID: 33828130 Free PMC article.
The molecular docking studies show strong binding of the CTL construct with MHC-1 and host membrane specific TLR2 receptors. The molecular dynamics simulation in an explicit system confirmed the stable and robust binding of CTL epitope with TLR2. Steep magnitude RMS …
The molecular docking studies show strong binding of the CTL construct with MHC-1 and host membrane specific TLR2 receptors. The mole …
SARS-CoV-2 infection as a trigger of humoral response against apolipoprotein A-1.
Pagano S, Yerly S, Meyer B, Juillard C, Suh N, Le Terrier C, Daguer JP, Farrera-Soler L, Barluenga S, Piumatti G, Hartley O, Lemaitre B, Eberhardt CS, Siegrist CA, Eckerle I, Stringhini S, Guessous I, Kaiser L, Pugin J, Winssinger N, Vuilleumier N. Pagano S, et al. Eur J Clin Invest. 2021 Nov;51(11):e13661. doi: 10.1111/eci.13661. Epub 2021 Aug 4. Eur J Clin Invest. 2021. PMID: 34324704 Free PMC article.
We aimed at determining (a) the association between anti-SARS-CoV-2 and anti-apoA-1 humoral response and (b) the degree of linear homology between SARS-CoV-2, apoA-1 and Toll-like receptor 2 (TLR2) epitopes. DESIGN: Bioinformatics modelling coupled with mimic peptides engi …
We aimed at determining (a) the association between anti-SARS-CoV-2 and anti-apoA-1 humoral response and (b) the degree of linear homology b …
CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections.
Sung PS, Hsieh SL. Sung PS, et al. Front Immunol. 2019 Dec 6;10:2867. doi: 10.3389/fimmu.2019.02867. eCollection 2019. Front Immunol. 2019. PMID: 31867016 Free PMC article. Review.
Although CLEC2 has been reported to interact with type I immunodeficiency virus (HIV-1), its role in viral infections is still unclear. CLEC5A binds to fucose and mannose moieties of dengue virus membrane glycans, as well as to N-acetylglucosamine (GlcNAc)/N-acetylm …
Although CLEC2 has been reported to interact with type I immunodeficiency virus (HIV-1), its role in viral infections is still unclea …
651 results