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562 results
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Dual TLR2 and TLR7 agonists as HIV latency-reversing agents.
Macedo AB, Novis CL, De Assis CM, Sorensen ES, Moszczynski P, Huang SH, Ren Y, Spivak AM, Jones RB, Planelles V, Bosque A. Macedo AB, et al. JCI Insight. 2018 Oct 4;3(19):e122673. doi: 10.1172/jci.insight.122673. JCI Insight. 2018. PMID: 30282829 Free PMC article.
Here, we characterized synthetic molecules composed of a TLR2 and a TLR7 agonist (dual TLR2/7 agonists) as latency-reversing agents and compared their activity with that of the TLR2 agonist Pam2CSK4 and the TLR7 agonist GS-9620. ...Furthermore, the TLR2
Here, we characterized synthetic molecules composed of a TLR2 and a TLR7 agonist (dual TLR2/7 agonists) as latency-reversing a …
Interplay between dengue virus and Toll-like receptors, RIG-I/MDA5 and microRNAs: Implications for pathogenesis.
Urcuqui-Inchima S, Cabrera J, Haenni AL. Urcuqui-Inchima S, et al. Antiviral Res. 2017 Nov;147:47-57. doi: 10.1016/j.antiviral.2017.09.017. Epub 2017 Sep 28. Antiviral Res. 2017. PMID: 28965915 Review.
Recognition by TLR2 and TLR4 also promotes the activation of other intracellular pathways and alters viral replication in an interferon-independent manner. ...To accomplish this, miRNAs bind either directly to viral RNA, through base-pair complementarity affecting translat …
Recognition by TLR2 and TLR4 also promotes the activation of other intracellular pathways and alters viral replication in an interfer …
Comparison of adjuvants to optimize influenza neutralizing antibody responses.
Rudicell RS, Garinot M, Kanekiyo M, Kamp HD, Swanson K, Chou TH, Dai S, Bedel O, Simard D, Gillespie RA, Yang K, Reardon M, Avila LZ, Besev M, Dhal PK, Dharanipragada R, Zheng L, Duan X, Dinapoli J, Vogel TU, Kleanthous H, Mascola JR, Graham BS, Haensler J, Wei CJ, Nabel GJ. Rudicell RS, et al. Vaccine. 2019 Sep 30;37(42):6208-6220. doi: 10.1016/j.vaccine.2019.08.030. Epub 2019 Sep 5. Vaccine. 2019. PMID: 31493950
Seasonal influenza vaccines represent a positive intervention to limit the spread of the virus and protect public health. Yet continual influenza evolution and its ability to evade immunity pose a constant threat. ...HA-NPs were compatible with nearly all adjuvants tested, …
Seasonal influenza vaccines represent a positive intervention to limit the spread of the virus and protect public health. Yet continu …
CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections.
Sung PS, Hsieh SL. Sung PS, et al. Front Immunol. 2019 Dec 6;10:2867. doi: 10.3389/fimmu.2019.02867. eCollection 2019. Front Immunol. 2019. PMID: 31867016 Free PMC article. Review.
Although CLEC2 has been reported to interact with type I immunodeficiency virus (HIV-1), its role in viral infections is still unclear. ...Moreover, activation of CLEC2 by dengue virus (DV) and H5N1 influenza virus (IAV) induces the release of extracellular v …
Although CLEC2 has been reported to interact with type I immunodeficiency virus (HIV-1), its role in viral infections is still unclea …
SARS coronavirus spike protein-induced innate immune response occurs via activation of the NF-kappaB pathway in human monocyte macrophages in vitro.
Dosch SF, Mahajan SD, Collins AR. Dosch SF, et al. Virus Res. 2009 Jun;142(1-2):19-27. doi: 10.1016/j.virusres.2009.01.005. Epub 2009 Jan 29. Virus Res. 2009. PMID: 19185596 Free PMC article.
An NF-kappaB inhibitor, TPCK (N-Tosyl-L-Phenylalanine Chloromethyl Ketone) could suppress IL-8 production and secretion in response to S protein in PBMC and THP-1 cells and in HCoV-229E virus-infected PBMC. ...
An NF-kappaB inhibitor, TPCK (N-Tosyl-L-Phenylalanine Chloromethyl Ketone) could suppress IL-8 production and secretion in response to S pro …
25-Hydroxyvitamin D3 and 1,25 Dihydroxyvitamin D3 as an Antiviral and Immunomodulator Against Herpes Simplex Virus-1 Infection in HeLa Cells.
Kumar A, Singh MP, Kumar RS, Ratho RK. Kumar A, et al. Viral Immunol. 2018 Oct;31(8):589-593. doi: 10.1089/vim.2018.0026. Epub 2018 May 24. Viral Immunol. 2018. PMID: 29792782
However, there is scanty literature available about the effect of vitamin D supplementation in herpes simplex virus-1 (HSV-1) infection. ...However, the effect of 25D3 supplementation persisted till 24 h p.i. with significant downregulation of TLR2 (p < 0.05) mRN …
However, there is scanty literature available about the effect of vitamin D supplementation in herpes simplex virus-1 (HSV-1) infecti …
The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis.
Patarčić I, Gelemanović A, Kirin M, Kolčić I, Theodoratou E, Baillie KJ, de Jong MD, Rudan I, Campbell H, Polašek O. Patarčić I, et al. Sci Rep. 2015 Nov 3;5:16119. doi: 10.1038/srep16119. Sci Rep. 2015. PMID: 26524966 Free PMC article. Review.
We performed meta-analyses of studies on tuberculosis, influenza, respiratory syncytial virus, SARS-Coronavirus and pneumonia. ...We also detected an association of TLR2 gene with tuberculosis (rs5743708; 3.19 [2.03-5.02]). Subset analyses identified CCL2 as an addi …
We performed meta-analyses of studies on tuberculosis, influenza, respiratory syncytial virus, SARS-Coronavirus and pneumonia. ...We …
Toll-like receptor 3 activation selectively reverses HIV latency in microglial cells.
Alvarez-Carbonell D, Garcia-Mesa Y, Milne S, Das B, Dobrowolski C, Rojas R, Karn J. Alvarez-Carbonell D, et al. Retrovirology. 2017 Feb 6;14(1):9. doi: 10.1186/s12977-017-0335-8. Retrovirology. 2017. PMID: 28166799 Free PMC article.
LPS (TLR4 agonist), flagellin (TLR5 agonist), and FSL-1 (TLR6 agonist) reactivated HIV to a lesser extent, while Pam3CSK4 (TLR2/1 agonist) and HKLM (TLR2 agonist) only weakly reversed HIV latency in these cells. While agonists for TLR2/1, 4, 5 and 6 reactivat …
LPS (TLR4 agonist), flagellin (TLR5 agonist), and FSL-1 (TLR6 agonist) reactivated HIV to a lesser extent, while Pam3CSK4 (TLR2/1 ago …
Direct antiviral properties of TLR ligands against HBV replication in immune-competent hepatocytes.
Lucifora J, Bonnin M, Aillot L, Fusil F, Maadadi S, Dimier L, Michelet M, Floriot O, Ollivier A, Rivoire M, Ait-Goughoulte M, Daffis S, Fletcher SP, Salvetti A, Cosset FL, Zoulim F, Durantel D. Lucifora J, et al. Sci Rep. 2018 Mar 29;8(1):5390. doi: 10.1038/s41598-018-23525-w. Sci Rep. 2018. PMID: 29599452 Free PMC article.
Current therapies for chronic hepatitis B virus (HBV) infections are effective at decreasing the viral load in serum, but do not lead to viral eradication. ...Moreover, TLR2 and TLR3 ligands can activate hepatocytes and immune cells, as demonstrated by antiviral cyt …
Current therapies for chronic hepatitis B virus (HBV) infections are effective at decreasing the viral load in serum, but do not lead …
Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1+ regulatory B cell expansion.
Ye L, Zhang Q, Cheng Y, Chen X, Wang G, Shi M, Zhang T, Cao Y, Pan H, Zhang L, Wang G, Deng Y, Yang Y, Chen G. Ye L, et al. J Immunother Cancer. 2018 Dec 10;6(1):145. doi: 10.1186/s40425-018-0451-6. J Immunother Cancer. 2018. PMID: 30526680 Free PMC article.
CONCLUSIONS: Our results illuminate a novel mechanism of TIM-1(+)Breg cell-mediated immune escape in HCC and provide functional evidence for the use of these novel exosomal HMGB1-TLR2/4-MAPK pathways to prevent and to treat this immune tolerance feature of HCC....
CONCLUSIONS: Our results illuminate a novel mechanism of TIM-1(+)Breg cell-mediated immune escape in HCC and provide functional evidence for …
562 results
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