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Highly Combinatorial Genetic Interaction Analysis Reveals a Multi-Drug Transporter Influence Network.
Celaj A, Gebbia M, Musa L, Cote AG, Snider J, Wong V, Ko M, Fong T, Bansal P, Mellor JC, Seesankar G, Nguyen M, Zhou S, Wang L, Kishore N, Stagljar I, Suzuki Y, Yachie N, Roth FP. Celaj A, et al. Among authors: wang l. Cell Syst. 2020 Jan 22;10(1):25-38.e10. doi: 10.1016/j.cels.2019.09.009. Epub 2019 Oct 23. Cell Syst. 2020. PMID: 31668799 Free PMC article.
Many traits are complex, depending non-additively on variant combinations. Even in model systems, such as the yeast S. cerevisiae, carrying out the high-order variant-combination testing needed to dissect complex traits remains a daunting challenge. ...We demonstrate XGA o …
Many traits are complex, depending non-additively on variant combinations. Even in model systems, such as the yeast S. cerevisiae, ca …