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Year Number of Results
1999 2
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2003 1
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2009 1
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51 results

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Page 1
A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.
Ghigo A, Murabito A, Sala V, Pisano AR, Bertolini S, Gianotti A, Caci E, Montresor A, Premchandar A, Pirozzi F, Ren K, Della Sala A, Mergiotti M, Richter W, de Poel E, Matthey M, Caldrer S, Cardone RA, Civiletti F, Costamagna A, Quinney NL, Butnarasu C, Visentin S, Ruggiero MR, Baroni S, Crich SG, Ramel D, Laffargue M, Tocchetti CG, Levi R, Conti M, Lu XY, Melotti P, Sorio C, De Rose V, Facchinetti F, Fanelli V, Wenzel D, Fleischmann BK, Mall MA, Beekman J, Laudanna C, Gentzsch M, Lukacs GL, Pedemonte N, Hirsch E. Ghigo A, et al. Among authors: richter w. Sci Transl Med. 2022 Mar 30;14(638):eabl6328. doi: 10.1126/scitranslmed.abl6328. Epub 2022 Mar 30. Sci Transl Med. 2022. PMID: 35353541 Free PMC article.
Cyclic adenosine 3',5'-monophosphate (cAMP)-elevating agents, such as beta(2)-adrenergic receptor (beta(2)-AR) agonists and phosphodiesterase (PDE) inhibitors, remain a mainstay in the treatment of obstructive respiratory diseases, conditions characterized by airway constr …
Cyclic adenosine 3',5'-monophosphate (cAMP)-elevating agents, such as beta(2)-adrenergic receptor (beta(2)-AR) agonists and phosphodieste …
PDE4 as a target for cognition enhancement.
Richter W, Menniti FS, Zhang HT, Conti M. Richter W, et al. Expert Opin Ther Targets. 2013 Sep;17(9):1011-27. doi: 10.1517/14728222.2013.818656. Epub 2013 Jul 25. Expert Opin Ther Targets. 2013. PMID: 23883342 Free PMC article. Review.
INTRODUCTION: The second messengers cAMP and cGMP mediate fundamental aspects of brain function relevant to memory, learning, and cognitive functions. Consequently, cyclic nucleotide phosphodiesterases (PDEs), the enzymes that inactivate the cyclic nucleotides, are promisi …
INTRODUCTION: The second messengers cAMP and cGMP mediate fundamental aspects of brain function relevant to memory, learning, and cognitive …
The cAMP-phosphodiesterase PDE4B2 controls peroxisome proliferator-activated receptor gamma expression and the initiation of adipogenesis in 3T3-L1 cells.
Fiedler E, Boyd A, Irelan D, Rachek LI, Abou Saleh L, Richter W. Fiedler E, et al. Among authors: richter w. Am J Physiol Endocrinol Metab. 2025 Dec 1;329(6):E874-E887. doi: 10.1152/ajpendo.00215.2025. Epub 2025 Oct 13. Am J Physiol Endocrinol Metab. 2025. PMID: 41083256 Free PMC article.
The cyclic adenosine monophosphate (cAMP)-phosphodiesterase 4 (PDE4) family comprises four genes that together are expressed as 25 protein variants. ...
The cyclic adenosine monophosphate (cAMP)-phosphodiesterase 4 (PDE4) family comprises four genes that together are expressed as 25 pr …
Identification of a novel PDE4 inhibitor inspired by leoligin-derived lignans.
Coffey C, Perhal AF, Richter W, Chen Y, Linder T, Schwaiger S, Mihovilovic MD, Kirchmair J, Schnürch M, Dirsch VM. Coffey C, et al. Among authors: richter w. Eur J Med Chem. 2026 Jan 15;302(Pt 1):118285. doi: 10.1016/j.ejmech.2025.118285. Epub 2025 Oct 20. Eur J Med Chem. 2026. PMID: 41124883 Free article.
The phosphodiesterase 4 (PDE4) family comprises isoenzymes that selectively hydrolyse the second messenger cyclic adenosine monophosphate (cAMP). ...
The phosphodiesterase 4 (PDE4) family comprises isoenzymes that selectively hydrolyse the second messenger cyclic adenosine monophosp …
PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.
McDonough W, Aragon IV, Rich J, Murphy JM, Abou Saleh L, Boyd A, Koloteva A, Richter W. McDonough W, et al. Among authors: richter w. FASEB J. 2020 Sep;34(9):12533-12548. doi: 10.1096/fj.202001016RR. Epub 2020 Aug 1. FASEB J. 2020. PMID: 32738081 Free PMC article.
Inhibitors of cAMP-phosphodiesterase 4 (PDE4) exert a number of promising therapeutic benefits, but adverse effects, in particular emesis and nausea, have curbed their clinical utility. ...
Inhibitors of cAMP-phosphodiesterase 4 (PDE4) exert a number of promising therapeutic benefits, but adverse effects, in particular em …
A CaMKII/PDE4D negative feedback regulates cAMP signaling.
Mika D, Richter W, Conti M. Mika D, et al. Among authors: richter w. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2023-8. doi: 10.1073/pnas.1419992112. Epub 2015 Feb 2. Proc Natl Acad Sci U S A. 2015. PMID: 25646485 Free PMC article.
To maintain homeostasis, cyclic nucleotide levels are regulated by phosphodiesterases (PDEs), with PDE4s predominantly responsible for cAMP degradation in the rodent heart. ...
To maintain homeostasis, cyclic nucleotide levels are regulated by phosphodiesterases (PDEs), with PDE4s predominantly responsible fo …
Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.
Aragon IV, Boyd A, Abou Saleh L, Rich J, McDonough W, Koloteva A, Richter W. Aragon IV, et al. Among authors: richter w. Biochem Pharmacol. 2021 Apr;186:114477. doi: 10.1016/j.bcp.2021.114477. Epub 2021 Feb 18. Biochem Pharmacol. 2021. PMID: 33609559 Free PMC article.
Here, we show that inhibition of cAMP-phosphodiesterase 4 (PDE4), while not inducing anesthesia by itself, potently enhances the anesthetic effects of Isoflurane in mice. ...
Here, we show that inhibition of cAMP-phosphodiesterase 4 (PDE4), while not inducing anesthesia by itself, potently enhances the anes …
Phosphodiesterase 10A (PDE10A) as a novel target to suppress beta-catenin and RAS signaling in epithelial ovarian cancer.
Borneman RM, Gavin E, Musiyenko A, Richter W, Lee KJ, Crossman DK, Andrews JF, Wilhite AM, McClellan S, Aragon I, Ward AB, Chen X, Keeton AB, Berry K, Piazza GA, Scalici JM, da Silva LM. Borneman RM, et al. Among authors: richter w. J Ovarian Res. 2022 Nov 2;15(1):120. doi: 10.1186/s13048-022-01050-9. J Ovarian Res. 2022. PMID: 36324187 Free PMC article.
Previous studies suggest the antineoplastic activity of NSAIDs is COX independent, and rather may be exerted through phosphodiesterase (PDE) inhibition. PDEs represent a unique chemopreventive target for ovarian cancer given that ovulation is regulated by cyclic nucleotide …
Previous studies suggest the antineoplastic activity of NSAIDs is COX independent, and rather may be exerted through phosphodiesterase …
51 results