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2020 6
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Page 1
A new framework for host-pathogen interaction research.
Yu H, Li L, Huffman A, Beverley J, Hur J, Merrell E, Huang HH, Wang Y, Liu Y, Ong E, Cheng L, Zeng T, Zhang J, Li P, Liu Z, Wang Z, Zhang X, Ye X, Handelman SK, Sexton J, Eaton K, Higgins G, Omenn GS, Athey B, Smith B, Chen L, He Y. Yu H, et al. Among authors: he y. Front Immunol. 2022 Dec 15;13:1066733. doi: 10.3389/fimmu.2022.1066733. eCollection 2022. Front Immunol. 2022. PMID: 36591248 Free PMC article.
As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occ …
As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infe …
A comprehensive update on CIDO: the community-based coronavirus infectious disease ontology.
He Y, Yu H, Huffman A, Lin AY, Natale DA, Beverley J, Zheng L, Perl Y, Wang Z, Liu Y, Ong E, Wang Y, Huang P, Tran L, Du J, Shah Z, Shah E, Desai R, Huang HH, Tian Y, Merrell E, Duncan WD, Arabandi S, Schriml LM, Zheng J, Masci AM, Wang L, Liu H, Smaili FZ, Hoehndorf R, Pendlington ZM, Roncaglia P, Ye X, Xie J, Tang YW, Yang X, Peng S, Zhang L, Chen L, Hur J, Omenn GS, Athey B, Smith B. He Y, et al. J Biomed Semantics. 2022 Oct 21;13(1):25. doi: 10.1186/s13326-022-00279-z. J Biomed Semantics. 2022. PMID: 36271389 Free PMC article.
CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms …
CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Pr …
COVID-19-associated AKI in hospitalized US patients: incidence, temporal trends, geographical distribution, risk factors and mortality.
Masthead; Yoo YJ, Wilkins KJ, Alakwaa F, Liu F, Torre-Healy LA, Krichevsky S, Hong SS, Sakhuja A, Potu CK, Saltz JH, Saran R, Zhu RL, Setoguchi S, Kane-Gill SL, Mallipattu SK, He Y, Ellison DH, Byrd JB, Parikh CR, Moffitt RA, Koraishy FM. Masthead, et al. Among authors: he y. medRxiv. 2022 Sep 2:2022.09.02.22279398. doi: 10.1101/2022.09.02.22279398. Preprint. medRxiv. 2022. PMID: 36093355 Free PMC article.
BACKGROUND: Acute kidney injury (AKI) is associated with mortality in patients hospitalized with COVID-19, however, its incidence, geographic distribution, and temporal trends since the start of the pandemic are understudied. ...The incidence and distribution …
BACKGROUND: Acute kidney injury (AKI) is associated with mortality in patients hospitalized with COVID-19, however, its …
Profiling COVID-19 Vaccine Adverse Events by Statistical and Ontological Analysis of VAERS Case Reports.
Guo W, Deguise J, Tian Y, Huang PC, Goru R, Yang Q, Peng S, Zhang L, Zhao L, Xie J, He Y. Guo W, et al. Among authors: he y. Front Pharmacol. 2022 Jun 24;13:870599. doi: 10.3389/fphar.2022.870599. eCollection 2022. Front Pharmacol. 2022. PMID: 35814246 Free PMC article.
Since the beginning of the COVID-19 pandemic, vaccines have been developed to mitigate the spread of SARS-CoV-2, the virus that causes COVID-19. ...Notably, severe COVID-19 vaccine AEs (including myocard …
Since the beginning of the COVID-19 pandemic, vaccines have been developed to mitigate the spread of SARS-CoV
COVID-19 vaccine design using reverse and structural vaccinology, ontology-based literature mining and machine learning.
Huffman A, Ong E, Hur J, D'Mello A, Tettelin H, He Y. Huffman A, et al. Among authors: he y. Brief Bioinform. 2022 Jul 18;23(4):bbac190. doi: 10.1093/bib/bbac190. Brief Bioinform. 2022. PMID: 35649389 Free PMC article.
Rational vaccine design, especially vaccine antigen identification and optimization, is critical to successful and efficient vaccine development against various infectious diseases including coronavirus disease 2019 (COVID-19). In general, computationa …
Rational vaccine design, especially vaccine antigen identification and optimization, is critical to successful and efficient vaccine develop …
Development and Applications of Interoperable Biomedical Ontologies for Integrative Data and Knowledge Representation and Multiscale Modeling in Systems Medicine.
He Y. He Y. Methods Mol Biol. 2022;2486:233-244. doi: 10.1007/978-1-0716-2265-0_12. Methods Mol Biol. 2022. PMID: 35437726
As a demonstration, the XOD strategy is applied to developing the interoperable Coronavirus Infectious Disease Ontology (CIDO). Various applications of interoperable ontologies, such as COVID-19 and kidney precision medicine research, are also introduced in t …
As a demonstration, the XOD strategy is applied to developing the interoperable Coronavirus Infectious Disease Ontology (CIDO). Vario …
Ontology-Based Classification and Analysis of Adverse Events Associated With the Usage of Chloroquine and Hydroxychloroquine.
Ngai J, Kalter M, Byrd JB, Racz R, He Y. Ngai J, et al. Among authors: he y. Front Pharmacol. 2022 Mar 23;13:812338. doi: 10.3389/fphar.2022.812338. eCollection 2022. Front Pharmacol. 2022. PMID: 35401219 Free PMC article.
According to EMBASE literature mining, CQ and HCQ were associated with QT prolongation (primarily when treating COVID-19), heart arrhythmias, development of Torsade des Pointes, and retinopathy (primarily when treating lupus). ...HCQ was associated with 63 significa …
According to EMBASE literature mining, CQ and HCQ were associated with QT prolongation (primarily when treating COVID-19), hea …
Differential COVID-19 Symptoms Given Pandemic Locations, Time, and Comorbidities During the Early Pandemic.
Wang Y, Zhang F, Byrd JB, Yu H, Ye X, He Y. Wang Y, et al. Among authors: he y. Front Med (Lausanne). 2022 Jan 28;9:770031. doi: 10.3389/fmed.2022.770031. eCollection 2022. Front Med (Lausanne). 2022. PMID: 35155491 Free PMC article.
BACKGROUND: COVID-19 pandemic is disaster to public health worldwide. Better perspective on COVID's features early in its course-prior to the development of vaccines and widespread variants-may prove useful in the understanding of future pandemics. ... …
BACKGROUND: COVID-19 pandemic is disaster to public health worldwide. Better perspective on COVID's features early in i …
Cov19VaxKB: A Web-based Integrative COVID-19 Vaccine Knowledge Base.
Huang PC, Goru R, Huffman A, Yu Lin A, Cooke MF, He Y. Huang PC, et al. Among authors: he y. Vaccine X. 2021 Dec 28;10:100139. doi: 10.1016/j.jvacx.2021.100139. Online ahead of print. Vaccine X. 2021. PMID: 34981039 Free PMC article.
The development of SARS-CoV-2 vaccines during the COVID-19 pandemic has prompted the emergence of COVID-19 vaccine data. ...Cov19VaxKB features comprehensive lists of COVID-19 vaccines, vaccine formulati …
The development of SARS-CoV-2 vaccines during the COVID-19 pandemic has prompted the emergence of …
Vaccine Design by Reverse Vaccinology and Machine Learning.
Ong E, He Y. Ong E, et al. Among authors: he y. Methods Mol Biol. 2022;2414:1-16. doi: 10.1007/978-1-0716-1900-1_1. Methods Mol Biol. 2022. PMID: 34784028
Vaxign-ML is also available as a command-based software package for more advanced and customizable vaccine antigen prediction. Both Vaxign and Vaxign-ML have been applied to predict SARS-CoV-2 (cause of COVID-19) and Brucella vaccine antigens to …
Vaxign-ML is also available as a command-based software package for more advanced and customizable vaccine antigen prediction. Both Vaxign a …
26 results