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Cyclodextrin protects podocytes in diabetic kidney disease.
Merscher-Gomez S, Guzman J, Pedigo CE, Lehto M, Aguillon-Prada R, Mendez A, Lassenius MI, Forsblom C, Yoo T, Villarreal R, Maiguel D, Johnson K, Goldberg R, Nair V, Randolph A, Kretzler M, Nelson RG, Burke GW 3rd, Groop PH, Fornoni A; FinnDiane Study Group. Merscher-Gomez S, et al. Diabetes. 2013 Nov;62(11):3817-27. doi: 10.2337/db13-0399. Epub 2013 Jul 8. Diabetes. 2013. PMID: 23835338 Free PMC article.
Diabetic kidney disease (DKD) remains the most common cause of end-stage kidney disease despite multifactorial intervention. ...Induction of cholesterol efflux with cyclodextrin (CD) but not inhibition of cholesterol synthesis with simvas …
Diabetic kidney disease (DKD) remains the most common cause of end-stage kidney disease despite multifact …
Crosstalk Between Lipids and Mitochondria in Diabetic Kidney Disease.
Ducasa GM, Mitrofanova A, Fornoni A. Ducasa GM, et al. Curr Diab Rep. 2019 Nov 21;19(12):144. doi: 10.1007/s11892-019-1263-x. Curr Diab Rep. 2019. PMID: 31754839 Free PMC article. Review.
PURPOSE OF REVIEW: The goal of this review is to review the role that renal parenchymal lipid accumulation plays in contributing to diabetic kidney disease (DKD), specifically contributing to the mitochondrial dysfunction observed in glomerular renal cells in …
PURPOSE OF REVIEW: The goal of this review is to review the role that renal parenchymal lipid accumulation plays in contributing to diabe …
SMPDL3b modulates insulin receptor signaling in diabetic kidney disease.
Mitrofanova A, Mallela SK, Ducasa GM, Yoo TH, Rosenfeld-Gur E, Zelnik ID, Molina J, Varona Santos J, Ge M, Sloan A, Kim JJ, Pedigo C, Bryn J, Volosenco I, Faul C, Zeidan YH, Garcia Hernandez C, Mendez AJ, Leibiger I, Burke GW, Futerman AH, Barisoni L, Ishimoto Y, Inagi R, Merscher S, Fornoni A. Mitrofanova A, et al. Nat Commun. 2019 Jun 19;10(1):2692. doi: 10.1038/s41467-019-10584-4. Nat Commun. 2019. PMID: 31217420 Free PMC article.
Here we report that SMPDL3b excess, as observed in podocytes in diabetic kidney disease (DKD), impairs insulin receptor isoform B-dependent pro-survival insulin signaling by interfering with insulin receptor isoforms binding to caveolin-1 in the PM. SM …
Here we report that SMPDL3b excess, as observed in podocytes in diabetic kidney disease (DKD), impairs insulin r …
Adenine crosses the biomarker bridge: from 'omics to treatment in diabetic kidney disease.
Drexler Y, Fornoni A. Drexler Y, et al. J Clin Invest. 2023 Oct 16;133(20):e174015. doi: 10.1172/JCI174015. J Clin Invest. 2023. PMID: 37843281 Free PMC article.
Enabling the early detection and prevention of diabetic kidney damage has potential to substantially reduce the global burden of kidney failure. ...In this issue of the JCI, Sharma and colleagues used an integrated multiomics approach to identify the metaboli …
Enabling the early detection and prevention of diabetic kidney damage has potential to substantially reduce the global burden …
Insulin signaling: implications for podocyte biology in diabetic kidney disease.
Coward R, Fornoni A. Coward R, et al. Curr Opin Nephrol Hypertens. 2015 Jan;24(1):104-10. doi: 10.1097/MNH.0000000000000078. Curr Opin Nephrol Hypertens. 2015. PMID: 25415617 Free PMC article.
Furthermore, podocyte-specific glucose transporter type 4 (GLUT4) deficiency protects podocytes by preventing mammalian target of rapamycin signaling independently of glucose uptake. Finally, intracellular lipids have been recently recognized as major modulat …
Furthermore, podocyte-specific glucose transporter type 4 (GLUT4) deficiency protects podocytes by preventing mammalian …