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Showing results for . Genome-editing technologies: principle and application
Your search for . Genome-editing technologies: principles and applications retrieved no results
Current applications and future perspective of CRISPR/Cas9 gene editing in cancer.
Wang SW, Gao C, Zheng YM, Yi L, Lu JC, Huang XY, Cai JB, Zhang PF, Cui YH, Ke AW. Wang SW, et al. Mol Cancer. 2022 Feb 21;21(1):57. doi: 10.1186/s12943-022-01518-8. Mol Cancer. 2022. PMID: 35189910 Free PMC article. Review.
This system inspires the development of a powerful genome engineering tool, the CRISPR/CRISPR-associated nuclease 9 (CRISPR/Cas9) genome editing system. ...Here, we review current status of CRISPR/Cas9 gene editing technology in oncologic …
This system inspires the development of a powerful genome engineering tool, the CRISPR/CRISPR-associated nuclease 9 (CRISPR/Cas9) …
Human Genome Editing: Science, Ethics, and Governance.
National Academies of Sciences, Engineering, and Medicine; National Academy of Medicine; National Academy of Sciences; Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations. National Academies of Sciences, Engineering, and Medicine, et al. Washington (DC): National Academies Press (US); 2017 Feb 14. Washington (DC): National Academies Press (US); 2017 Feb 14. PMID: 28796468 Free Books & Documents. Review.
Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. ...Human Genome Editing considers important questions about the human application of genome editing including: balancing potent …
Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. ...Human Genome …
Genome-editing technologies and their potential application in horticultural crop breeding.
Xiong JS, Ding J, Li Y. Xiong JS, et al. Hortic Res. 2015 May 13;2:15019. doi: 10.1038/hortres.2015.19. eCollection 2015. Hortic Res. 2015. PMID: 26504570 Free PMC article. Review.
Here, we first review the developmental process and applications of these technologies in horticultural crop breeding. Then, we mainly describe the principles of the latest genome-editing technologies and discuss their potential applic …
Here, we first review the developmental process and applications of these technologies in horticultural crop breeding. Then, w …
CRISPR/Cas9-Mediated Genome Editing in Cancer Therapy.
Ding S, Liu J, Han X, Tang M. Ding S, et al. Int J Mol Sci. 2023 Nov 15;24(22):16325. doi: 10.3390/ijms242216325. Int J Mol Sci. 2023. PMID: 38003514 Free PMC article. Review.
Here, we elucidate the fundamental principles of CRISPR/Cas9 gene editing and its practical applications in tumor research. We also briefly discuss the primary challenges faced by CRISPR technology and existing solutions, intending to enhance th …
Here, we elucidate the fundamental principles of CRISPR/Cas9 gene editing and its practical applications in tumo …
CRISPR/Cas9: Principle, Applications, and Delivery through Extracellular Vesicles.
Horodecka K, Düchler M. Horodecka K, et al. Int J Mol Sci. 2021 Jun 4;22(11):6072. doi: 10.3390/ijms22116072. Int J Mol Sci. 2021. PMID: 34199901 Free PMC article. Review.
The establishment of CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) technology for eukaryotic gene editing opened up new avenues not only for the analysis of gene function but also for therapeutic in …
The establishment of CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) technology f …
The genome editing revolution: review.
Khalil AM. Khalil AM. J Genet Eng Biotechnol. 2020 Oct 29;18(1):68. doi: 10.1186/s43141-020-00078-y. J Genet Eng Biotechnol. 2020. PMID: 33123803 Free PMC article. Review.
This review presents a brief history, basic principles, advantages and disadvantages, as well as various aspects of each genome editing technology including the modes, applications, and challenges that face delivery of gene editing …
This review presents a brief history, basic principles, advantages and disadvantages, as well as various aspects of each genome …
Emerging mRNA technologies: delivery strategies and biomedical applications.
Xiao Y, Tang Z, Huang X, Chen W, Zhou J, Liu H, Liu C, Kong N, Tao W. Xiao Y, et al. Chem Soc Rev. 2022 May 23;51(10):3828-3845. doi: 10.1039/d1cs00617g. Chem Soc Rev. 2022. PMID: 35437544 Review.
The great success achieved by the two highly-effective messenger RNA (mRNA) vaccines during the COVID-19 pandemic highlights the great potential of mRNA technology. Through the evolution of mRNA technology, chemistry has played an important role from mRNA modificati …
The great success achieved by the two highly-effective messenger RNA (mRNA) vaccines during the COVID-19 pandemic highlights the great poten …
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration.
Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nuñez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC. Suzuki K, et al. Nature. 2016 Dec 1;540(7631):144-149. doi: 10.1038/nature20565. Epub 2016 Nov 16. Nature. 2016. PMID: 27851729 Free PMC article.
Targeted genome editing via engineered nucleases is an exciting area of biomedical research and holds potential for clinical applications. ...The HITI method presented here establishes new avenues for basic research and targeted gene therapies....
Targeted genome editing via engineered nucleases is an exciting area of biomedical research and holds potential for clinical …
Progress and Perspective of CRISPR-Cas9 Technology in Translational Medicine.
Zheng R, Zhang L, Parvin R, Su L, Chi J, Shi K, Ye F, Huang X. Zheng R, et al. Adv Sci (Weinh). 2023 Sep;10(25):e2300195. doi: 10.1002/advs.202300195. Epub 2023 Jun 25. Adv Sci (Weinh). 2023. PMID: 37356052 Free PMC article. Review.
However, the progress in gene editing therapy has been hindered due to the severe off-target effects and limited editing sites. ...This review aims to present the latest CRISPR-Cas9 technology achievements and prospect to translational medicine advance …
However, the progress in gene editing therapy has been hindered due to the severe off-target effects and limited editing …
Targeted genome-modification tools and their advanced applications in crop breeding.
Li B, Sun C, Li J, Gao C. Li B, et al. Nat Rev Genet. 2024 Sep;25(9):603-622. doi: 10.1038/s41576-024-00720-2. Epub 2024 Apr 24. Nat Rev Genet. 2024. PMID: 38658741 Review.
In this Review, we systematically outline the technological principles underlying precise and targeted genome-modification methods. We also review methods for the delivery of genome-editing reagents in plants and outline emerging crop-breeding strategi …
In this Review, we systematically outline the technological principles underlying precise and targeted genome-modification met …
238 results