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International regulatory requirements for skin sensitization testing.
Daniel AB, Strickland J, Allen D, Casati S, Zuang V, Barroso J, Whelan M, Régimbald-Krnel MJ, Kojima H, Nishikawa A, Park HK, Lee JK, Kim TS, Delgado I, Rios L, Yang Y, Wang G, Kleinstreuer N. Daniel AB, et al. Regul Toxicol Pharmacol. 2018 Jun;95:52-65. doi: 10.1016/j.yrtph.2018.03.003. Epub 2018 Mar 6. Regul Toxicol Pharmacol. 2018. PMID: 29518484 Free PMC article. Review.
Thus, we reviewed skin sensitization testing requirements for seven countries or regions that are represented in the International Cooperation on Alternative Test Methods (ICATM). ...An understanding of national and regional regulatory
Thus, we reviewed skin sensitization testing requirements for seven countries or regions that are represented in …
Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods.
Casati S, Aschberger K, Barroso J, Casey W, Delgado I, Kim TS, Kleinstreuer N, Kojima H, Lee JK, Lowit A, Park HK, Régimbald-Krnel MJ, Strickland J, Whelan M, Yang Y, Zuang V. Casati S, et al. Arch Toxicol. 2018 Feb;92(2):611-617. doi: 10.1007/s00204-017-2097-4. Epub 2017 Nov 10. Arch Toxicol. 2018. PMID: 29127450 Free PMC article.
Skin sensitisation is the regulatory endpoint that has been at the centre of concerted efforts to replace animal testing in recent years, as demonstrated by the Organisation for Economic Co-operation and Development (OECD) adoption of five non-animal m
Skin sensitisation is the regulatory endpoint that has been at the centre of concerted efforts to replace animal tes
Skin sensitisation--moving forward with non-animal testing strategies for regulatory purposes in the EU.
Basketter D, Alépée N, Casati S, Crozier J, Eigler D, Griem P, Hubesch B, de Knecht J, Landsiedel R, Louekari K, Manou I, Maxwell G, Mehling A, Netzeva T, Petry T, Rossi LH. Basketter D, et al. Regul Toxicol Pharmacol. 2013 Dec;67(3):531-5. doi: 10.1016/j.yrtph.2013.10.002. Epub 2013 Oct 16. Regul Toxicol Pharmacol. 2013. PMID: 24140884
It is already recognised that information produced from non-animal assays can be used in regulatory decision-making, notably in terms of classifying a substance as a skin sensitiser. ...Based on these considerations, a follow up activity was agreed upon to ex …
It is already recognised that information produced from non-animal assays can be used in regulatory decision-making, notably in terms …
Deriving a No Expected Sensitization Induction Level for Fragrance Ingredients Without Animal Testing: An Integrated Approach Applied to Specific Case Studies.
Natsch A, Emter R, Haupt T, Ellis G. Natsch A, et al. Toxicol Sci. 2018 Sep 1;165(1):170-185. doi: 10.1093/toxsci/kfy135. Toxicol Sci. 2018. PMID: 29860528
However, Quantitative Risk Assessment for fragrance ingredients requires an NESIL (no expected sensitization induction level), a dose not expected to cause induction of skin sensitization in humans. ...We conclude that, in the data-rich domain of fragr …
However, Quantitative Risk Assessment for fragrance ingredients requires an NESIL (no expected sensitization induction level), …
Reflections on the progress towards non-animal methods for acute toxicity testing of chemicals.
Prior H, Casey W, Kimber I, Whelan M, Sewell F. Prior H, et al. Regul Toxicol Pharmacol. 2019 Mar;102:30-33. doi: 10.1016/j.yrtph.2018.12.008. Epub 2018 Dec 20. Regul Toxicol Pharmacol. 2019. PMID: 30578838 Free article.
The 'six-pack' is designed to provide information on health hazards likely to arise from short-term exposure to chemicals via inhalation, oral and dermal routes, including the potential for eye and skin irritation/corrosion and skin sensitization. The compone …
The 'six-pack' is designed to provide information on health hazards likely to arise from short-term exposure to chemicals via inhalation, or …
Local lymph node assay (LLNA) for detection of sensitization capacity of chemicals.
Gerberick GF, Ryan CA, Dearman RJ, Kimber I. Gerberick GF, et al. Methods. 2007 Jan;41(1):54-60. doi: 10.1016/j.ymeth.2006.07.006. Methods. 2007. PMID: 16938465 Review.
The assay relies on measurement of events induced during the induction phase of skin sensitization, specifically lymphocyte proliferation in the draining lymph nodes which is a hallmark of a skin sensitization response. ...Experience gained in recent y …
The assay relies on measurement of events induced during the induction phase of skin sensitization, specifically lymphocyte pr …
Methods for the prediction of low-molecular-weight occupational respiratory sensitizers.
Seed MJ, Cullinan P, Agius RM. Seed MJ, et al. Curr Opin Allergy Clin Immunol. 2008 Apr;8(2):103-9. doi: 10.1097/ACI.0b013e3282f4cadd. Curr Opin Allergy Clin Immunol. 2008. PMID: 18317016 Review.
PURPOSE OF REVIEW: There is recognition that respiratory sensitization is an occupational hazard of high concern. Despite international regulatory requirements there is no established protocol for the efficient prospective identification of chemical re …
PURPOSE OF REVIEW: There is recognition that respiratory sensitization is an occupational hazard of high concern. Despite internat
Acute toxicity testing of chemicals-Opportunities to avoid redundant testing and use alternative approaches.
Creton S, Dewhurst IC, Earl LK, Gehen SC, Guest RL, Hotchkiss JA, Indans I, Woolhiser MR, Billington R. Creton S, et al. Crit Rev Toxicol. 2010 Jan;40(1):50-83. doi: 10.3109/10408440903401511. Crit Rev Toxicol. 2010. PMID: 20144136 Review.
Assessment of the acute systemic oral, dermal, and inhalation toxicities, skin and eye irritancy, and skin sensitisation potential of chemicals is required under regulatory schemes worldwide. ...In vitro irritation models should receive wider ad …
Assessment of the acute systemic oral, dermal, and inhalation toxicities, skin and eye irritancy, and skin sensitisation
Classification of dermal sensitizers in pharmaceutical manufacturing.
Winkler GC, Perino C, Araya SH, Bechter R, Kuster M, Lovsin Barle E. Winkler GC, et al. Regul Toxicol Pharmacol. 2015 Aug;72(3):501-5. doi: 10.1016/j.yrtph.2015.05.026. Epub 2015 May 29. Regul Toxicol Pharmacol. 2015. PMID: 26028366
The status of alternative methods for regulatory toxicology for consumer products has recently been reviewed by the Organisation for Economic Co-operation and Development (OECD) and the European Commission's Joint Research Center (JRC) for the European Chemicals Age …
The status of alternative methods for regulatory toxicology for consumer products has recently been reviewed by the Organisation for …
Local lymph node assay: use in hazard and risk assessment.
Dearman RJ, Basketter DA, Kimber I. Dearman RJ, et al. J Appl Toxicol. 1999 Sep-Oct;19(5):299-306. doi: 10.1002/(sici)1099-1263(199909/10)19:5<299::aid-jat591>3.0.co;2-c. J Appl Toxicol. 1999. PMID: 10513674 Review.
The murine local lymph node assay (LLNA) was developed as an alternative method for the identification of chemicals that have the ability to cause skin sensitization and allergic contact dermatitis. The assay now has been evaluated extensively in the context of both …
The murine local lymph node assay (LLNA) was developed as an alternative method for the identification of chemicals that have the ability to …
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