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Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease.
Yao J, Ho D, Calingasan NY, Pipalia NH, Lin MT, Beal MF. Yao J, et al. J Exp Med. 2012 Dec 17;209(13):2501-13. doi: 10.1084/jem.20121239. Epub 2012 Dec 3. J Exp Med. 2012. PMID: 23209315 Free PMC article.
There is extensive evidence that cholesterol and membrane lipids play a key role in Alzheimer disease (AD) pathogenesis. Cyclodextrins (CD) are cyclic oligosaccharide compounds widely used to bind cholesterol. Because CD exerts significant beneficial effects …
There is extensive evidence that cholesterol and membrane lipids play a key role in Alzheimer disease (AD) pathogenesis. Cy
Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-beta Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer's Disease.
Ştefănescu R, Stanciu GD, Luca A, Caba IC, Tamba BI, Mihai CT. Ştefănescu R, et al. Molecules. 2019 Mar 24;24(6):1167. doi: 10.3390/molecules24061167. Molecules. 2019. PMID: 30909659 Free PMC article. Review.
Alzheimer's Disease affects approximately 33 million people worldwide and is characterized by progressive loss of memory at the cognitive level. ...In the present review we aim to identify in the scientific literature low molecular weight chemical compounds for whic
Alzheimer's Disease affects approximately 33 million people worldwide and is characterized by progressive loss of memory at th
Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C.
Dardis A, Zampieri S, Canterini S, Newell KL, Stuani C, Murrell JR, Ghetti B, Fiorenza MT, Bembi B, Buratti E. Dardis A, et al. Acta Neuropathol Commun. 2016 May 18;4(1):52. doi: 10.1186/s40478-016-0325-4. Acta Neuropathol Commun. 2016. PMID: 27193329 Free PMC article.
At present, the molecular mechanisms causing neurodegeneration in this disease are unknown. Here we report the altered expression and/or mislocalization of the TAR-DNA binding protein 43 (TDP-43) in both NPC mouse and in a human neuronal model of the disea
At present, the molecular mechanisms causing neurodegeneration in this disease are unknown. Here we report the altered expression and …