Abstract
WF14861, a novel cathepsins B and L inhibitor, was obtained from the culture mycelium of a fungus strain Colletotrichum sp. No. 14861. Spectroscopic analysis showed that WF14861 consisted of trans-epoxysuccinic acid, L-tyrosine and spermidine, WF14861 inhibited cathepsins B and L selectively.
MeSH terms
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Cathepsin B / antagonists & inhibitors*
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Cathepsin L
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Cathepsins / antagonists & inhibitors*
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Chemical Phenomena
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Chemistry, Physical
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Chromatography, High Pressure Liquid
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Colletotrichum / classification
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Colletotrichum / growth & development
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Colletotrichum / metabolism*
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Cysteine Endopeptidases
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Cysteine Proteinase Inhibitors* / chemistry
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Cysteine Proteinase Inhibitors* / isolation & purification
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Cysteine Proteinase Inhibitors* / metabolism
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Endopeptidases*
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Epoxy Compounds* / chemistry
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Epoxy Compounds* / isolation & purification
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Epoxy Compounds* / metabolism
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Fermentation
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Humans
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Liver / enzymology
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Spectrometry, Fluorescence
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Spectrometry, Mass, Fast Atom Bombardment
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Spermidine / chemistry
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Succinates / chemistry
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Tyrosine / analogs & derivatives*
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Tyrosine / biosynthesis
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Tyrosine / chemistry
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Tyrosine / isolation & purification
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Tyrosine / metabolism
Substances
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Cysteine Proteinase Inhibitors
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Epoxy Compounds
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Succinates
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WF 14861
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Tyrosine
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Cathepsins
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Endopeptidases
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Cysteine Endopeptidases
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Cathepsin B
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CTSL protein, human
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Cathepsin L
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Spermidine