WF14861, a new cathepsins B and L inhibitor produced by Colletotrichum sp. I. Taxonomy, production, purification and structure elucidation

J Antibiot (Tokyo). 1999 Jun;52(6):536-41. doi: 10.7164/antibiotics.52.536.

Abstract

WF14861, a novel cathepsins B and L inhibitor, was obtained from the culture mycelium of a fungus strain Colletotrichum sp. No. 14861. Spectroscopic analysis showed that WF14861 consisted of trans-epoxysuccinic acid, L-tyrosine and spermidine, WF14861 inhibited cathepsins B and L selectively.

MeSH terms

  • Cathepsin B / antagonists & inhibitors*
  • Cathepsin L
  • Cathepsins / antagonists & inhibitors*
  • Chemical Phenomena
  • Chemistry, Physical
  • Chromatography, High Pressure Liquid
  • Colletotrichum / classification
  • Colletotrichum / growth & development
  • Colletotrichum / metabolism*
  • Cysteine Endopeptidases
  • Cysteine Proteinase Inhibitors* / chemistry
  • Cysteine Proteinase Inhibitors* / isolation & purification
  • Cysteine Proteinase Inhibitors* / metabolism
  • Endopeptidases*
  • Epoxy Compounds* / chemistry
  • Epoxy Compounds* / isolation & purification
  • Epoxy Compounds* / metabolism
  • Fermentation
  • Humans
  • Liver / enzymology
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Spectrometry, Fluorescence
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spermidine / chemistry
  • Succinates / chemistry
  • Tyrosine / analogs & derivatives*
  • Tyrosine / biosynthesis
  • Tyrosine / chemistry
  • Tyrosine / isolation & purification
  • Tyrosine / metabolism

Substances

  • Cysteine Proteinase Inhibitors
  • Epoxy Compounds
  • Succinates
  • WF 14861
  • Tyrosine
  • Cathepsins
  • Endopeptidases
  • Cysteine Endopeptidases
  • Cathepsin B
  • CTSL protein, human
  • Cathepsin L
  • Spermidine