106169/ZZ14/Z/WT_/Wellcome Trust/United Kingdom[Grant Number] - Search Results

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Subject: 106169/ZZ14/Z/WT_/Wellcome Trust/United Kingdom[G - PubMed

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Results by year

Year	Number of Results
2017	3
2018	16
2019	36
2020	39
2021	30
2022	14
2023	3
2024	1

125 results

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PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo.

Brown EJ, Balaguer-Lluna L, Cribbs AP, Philpott M, Campo L, Browne M, Wong JF, Oppermann U, Carcaboso ÁM, Bullock AN, Farnie G. Brown EJ, et al. Sci Rep. 2024 Jan 3;14(1):328. doi: 10.1038/s41598-023-48652-x. Sci Rep. 2024. PMID: 38172189 Free PMC article.

SGC-CAMKK2-1: A Chemical Probe for CAMKK2.

Wells C, Liang Y, Pulliam TL, Lin C, Awad D, Eduful B, O'Byrne S, Hossain MA, Catta-Preta CMC, Ramos PZ, Gileadi O, Gileadi C, Couñago RM, Stork B, Langendorf CG, Nay K, Oakhill JS, Mukherjee D, Racioppi L, Means AR, York B, McDonnell DP, Scott JW, Frigo DE, Drewry DH. Wells C, et al. Cells. 2023 Jan 11;12(2):287. doi: 10.3390/cells12020287. Cells. 2023. PMID: 36672221 Free PMC article.

Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.

Amrhein JA, Beyett TS, Feng WW, Krämer A, Weckesser J, Schaeffner IK, Rana JK, Jänne PA, Eck MJ, Knapp S, Hanke T. Amrhein JA, et al. J Med Chem. 2022 Dec 8;65(23):15679-15697. doi: 10.1021/acs.jmedchem.2c01041. Epub 2022 Nov 16. J Med Chem. 2022. PMID: 36384036 Free PMC article.

Pathogenic Interleukin-10 Receptor Alpha Variants in Humans - Balancing Natural Selection and Clinical Implications.

Aschenbrenner D, Ye Z, Zhou Y, Hu W, Brooks I, Williams I, Capitani M, Gartner L, Kotlarz D, Snapper SB, Klein C, Muise AM, Marsden BD, Huang Y, Uhlig HH. Aschenbrenner D, et al. J Clin Immunol. 2023 Feb;43(2):495-511. doi: 10.1007/s10875-022-01366-7. Epub 2022 Nov 12. J Clin Immunol. 2023. PMID: 36370291 Free PMC article.

Small-molecule inhibition of the archetypal UbiB protein COQ8.

Murray NH, Asquith CRM, Fang Z, East MP, Ptak N, Smith RW, Vasta JD, Zimprich CA, Corona CR, Robers MB, Johnson GL, Bingman CA, Pagliarini DJ. Murray NH, et al. Nat Chem Biol. 2023 Feb;19(2):230-238. doi: 10.1038/s41589-022-01168-3. Epub 2022 Oct 27. Nat Chem Biol. 2023. PMID: 36302899 Free PMC article.

Optimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform.

Bieberich AA, Laitinen T, Maffuid K, Fatig RO 3rd, Torrice CD, Morris DC, Crona DJ, Asquith CRM. Bieberich AA, et al. Sci Rep. 2022 Jul 27;12(1):12820. doi: 10.1038/s41598-022-15552-5. Sci Rep. 2022. PMID: 35896603 Free PMC article.

Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling.

Agajanian MJ, Potjewyd FM, Bowman BM, Solomon S, LaPak KM, Bhatt DP, Smith JL, Goldfarb D, Axtman AD, Major MB. Agajanian MJ, et al. J Biol Chem. 2022 Jun;298(6):101986. doi: 10.1016/j.jbc.2022.101986. Epub 2022 Apr 27. J Biol Chem. 2022. PMID: 35487243 Free PMC article.

Identification of 4-Anilinoquin(az)oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype.

Asquith CRM, Temme L, East MP, Laitinen T, Pickett J, Kwarcinski FE, Sinha P, Wells CI, Johnson GL, Zutshi R, Drewry DH. Asquith CRM, et al. ChemMedChem. 2022 Jun 20;17(12):e202200161. doi: 10.1002/cmdc.202200161. Epub 2022 May 9. ChemMedChem. 2022. PMID: 35403825 Free PMC article.

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.

Chen Z, Ioris RM, Richardson S, Van Ess AN, Vendrell I, Kessler BM, Buffa FM, Busino L, Clifford SC, Bullock AN, D'Angiolella V. Chen Z, et al. Cell Death Differ. 2022 Oct;29(10):1955-1969. doi: 10.1038/s41418-022-00983-4. Epub 2022 Apr 4. Cell Death Differ. 2022. PMID: 35379950 Free PMC article.

PRMT5 regulates ATF4 transcript splicing and oxidative stress response.

Szewczyk MM, Luciani GM, Vu V, Murison A, Dilworth D, Barghout SH, Lupien M, Arrowsmith CH, Minden MD, Barsyte-Lovejoy D. Szewczyk MM, et al. Redox Biol. 2022 May;51:102282. doi: 10.1016/j.redox.2022.102282. Epub 2022 Mar 11. Redox Biol. 2022. PMID: 35305370 Free PMC article.

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