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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1919 1
1923 1
1924 1
1925 2
1928 2
1945 2
1946 7
1947 12
1948 12
1949 9
1950 5
1951 14
1952 12
1953 20
1954 16
1955 13
1956 19
1957 9
1958 6
1959 13
1960 19
1961 20
1962 27
1963 29
1964 30
1965 48
1966 59
1967 92
1968 117
1969 114
1970 128
1971 157
1972 194
1973 236
1974 256
1975 951
1976 1087
1977 1097
1978 1208
1979 1411
1980 1613
1981 1871
1982 1984
1983 2634
1984 2894
1985 3318
1986 3696
1987 4258
1988 4674
1989 6075
1990 6611
1991 7557
1992 8359
1993 9539
1994 10786
1995 12249
1996 13758
1997 15111
1998 16971
1999 19121
2000 21976
2001 24362
2002 27214
2003 30936
2004 36175
2005 40416
2006 45873
2007 50463
2008 55927
2009 60579
2010 69651
2011 79167
2012 88158
2013 96376
2014 104773
2015 113247
2016 120136
2017 127249
2018 135306
2019 146142
2020 169222
2021 190163
2022 192227
2023 188411
2024 161005
2025 227

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2,276,621 results

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The following term was not found in PubMed: 19621064
Page 1
Chasing molecular glue degraders: screening approaches.
Domostegui A, Nieto-Barrado L, Perez-Lopez C, Mayor-Ruiz C. Domostegui A, et al. Chem Soc Rev. 2022 Jul 4;51(13):5498-5517. doi: 10.1039/d2cs00197g. Chem Soc Rev. 2022. PMID: 35723413 Review.
In particular, molecular glue degraders are monovalent compounds that orchestrate interactions between a target protein and an E3 ubiquitin ligase, prompting the proteasomal degradation of the former. This and other pharmacological strategies of targeted protein deg …
In particular, molecular glue degraders are monovalent compounds that orchestrate interactions between a target protein and an E3 ubi …
The Osteosarcoma Microenvironment: A Complex But Targetable Ecosystem.
Corre I, Verrecchia F, Crenn V, Redini F, Trichet V. Corre I, et al. Cells. 2020 Apr 15;9(4):976. doi: 10.3390/cells9040976. Cells. 2020. PMID: 32326444 Free PMC article. Review.
Consequently, efforts to improve treatments using targeted therapies have faced this lack of specific osteosarcoma targets. Nevertheless, these tumors are inextricably linked to their local microenvironment, composed of bone, stromal, vascular and immune cells and t …
Consequently, efforts to improve treatments using targeted therapies have faced this lack of specific osteosarcoma targets. Ne …
Synthetic Lethality in Cancer Therapeutics: The Next Generation.
Setton J, Zinda M, Riaz N, Durocher D, Zimmermann M, Koehler M, Reis-Filho JS, Powell SN. Setton J, et al. Cancer Discov. 2021 Jul;11(7):1626-1635. doi: 10.1158/2159-8290.CD-20-1503. Epub 2021 Apr 1. Cancer Discov. 2021. PMID: 33795234 Free PMC article. Review.
Recent technological advances have led to an inflection point in our understanding of genetic interaction networks and ability to identify a wide array of novel SL drug targets. Here, we review concepts and lessons emerging from first-generation trials aimed at testing SL …
Recent technological advances have led to an inflection point in our understanding of genetic interaction networks and ability to identify a …
Strategies for targeting undruggable targets.
Zhang G, Zhang J, Gao Y, Li Y, Li Y. Zhang G, et al. Expert Opin Drug Discov. 2022 Jan;17(1):55-69. doi: 10.1080/17460441.2021.1969359. Epub 2021 Aug 30. Expert Opin Drug Discov. 2022. PMID: 34455870 Review.
INTRODUCTION: Undruggable targets refer to clinically meaningful therapeutic targets that are 'difficult to drug' or 'yet to be drugged' via traditional approaches. ...EXPERT OPINION: Targeting the undruggable expands the scope of therapeutically reachable …
INTRODUCTION: Undruggable targets refer to clinically meaningful therapeutic targets that are 'difficult to drug' or 'yet to b …
Genome engineering with zinc-finger nucleases.
Carroll D. Carroll D. Genetics. 2011 Aug;188(4):773-82. doi: 10.1534/genetics.111.131433. Genetics. 2011. PMID: 21828278 Free PMC article. Review.
Zinc-finger nucleases (ZFNs) are targetable DNA cleavage reagents that have been adopted as gene-targeting tools. ZFN-induced double-strand breaks are subject to cellular DNA repair processes that lead to both targeted mutagenesis and targeted gene rep …
Zinc-finger nucleases (ZFNs) are targetable DNA cleavage reagents that have been adopted as gene-targeting tools. ZFN-induced …
Targeting thromboinflammation in antiphospholipid syndrome.
Salet DM, Bekkering S, Middeldorp S, van den Hoogen LL. Salet DM, et al. J Thromb Haemost. 2023 Apr;21(4):744-757. doi: 10.1016/j.jtha.2022.12.002. Epub 2022 Dec 22. J Thromb Haemost. 2023. PMID: 36696191 Free article. Review.
All of these may serve as future therapeutic targets. Neutrophils produce neutrophil extracellular traps in response to aPL, and this leads to thrombosis. ...This review discusses mechanisms underlying thromboinflammation in APS that present targetable therapeutic o …
All of these may serve as future therapeutic targets. Neutrophils produce neutrophil extracellular traps in response to aPL, and this …
Targeted Drug Delivery: Trends and Perspectives.
Ashique S, Sandhu NK, Chawla V, Chawla PA. Ashique S, et al. Curr Drug Deliv. 2021;18(10):1435-1455. doi: 10.2174/1567201818666210609161301. Curr Drug Deliv. 2021. PMID: 34151759 Review.
A focused drug transport aims to extend, localize, target and have a safe drug interaction with the diseased tissue. OBJECTIVE: The aim of targeted drug delivery is to make the required amount of the drug available at its desired site of action. ...Overall, the arti …
A focused drug transport aims to extend, localize, target and have a safe drug interaction with the diseased tissue. OBJECTIVE: The a …
Electrophilic warheads in covalent drug discovery: an overview.
Péczka N, Orgován Z, Ábrányi-Balogh P, Keserű GM. Péczka N, et al. Expert Opin Drug Discov. 2022 Apr;17(4):413-422. doi: 10.1080/17460441.2022.2034783. Epub 2022 Feb 6. Expert Opin Drug Discov. 2022. PMID: 35129005 Review.
The warheads are discussed by targeted residues, mechanism and selectivity, and analyzed through three different datasets including our collection of warheads, the CovPDB database, and the FDA approved covalent drugs. ...However, versatile, selective warheads are not avail …
The warheads are discussed by targeted residues, mechanism and selectivity, and analyzed through three different datasets including o …
Targeted therapy and drug resistance in triple-negative breast cancer: the EGFR axis.
Lev S. Lev S. Biochem Soc Trans. 2020 Apr 29;48(2):657-665. doi: 10.1042/BST20191055. Biochem Soc Trans. 2020. PMID: 32311020 Review.
However, for triple-negative breast cancer (TNBC), an aggressive breast cancer subtype, there are no clinically approved targeted therapies, and thus, an urgent need to identify potent, highly effective therapeutic targets. In this mini-review, we describe general s …
However, for triple-negative breast cancer (TNBC), an aggressive breast cancer subtype, there are no clinically approved targeted the …
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy.
Tang T, Huang X, Zhang G, Hong Z, Bai X, Liang T. Tang T, et al. Signal Transduct Target Ther. 2021 Feb 20;6(1):72. doi: 10.1038/s41392-020-00449-4. Signal Transduct Target Ther. 2021. PMID: 33608497 Free PMC article. Review.
More importantly, we highlight the critical role of tumor immune microenvironment regulators in tumor immune surveillance, immunological evasion, and the potential for their further translation into clinical practice. Based on their general targetability in clinical therap …
More importantly, we highlight the critical role of tumor immune microenvironment regulators in tumor immune surveillance, immunological eva …
2,276,621 results
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