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Replacement of two invariant serine residues in chorismate synthase provides evidence that a proton relay system is essential for intermediate formation and catalytic activity.
FEBS J. 2008 Apr;275(7):1464-1473. doi: 10.1111/j.1742-4658.2008.06305.x. Epub 2008 Feb 14.
FEBS J. 2008.
PMID: 18279385
Free article.
Mutagenic analysis of an invariant aspartate residue in chorismate synthase supports its role as an active site base.
Rauch G, Ehammer H, Bornemann S, Macheroux P.
Rauch G, et al.
Biochemistry. 2007 Mar 27;46(12):3768-74. doi: 10.1021/bi602420u. Epub 2007 Feb 28.
Biochemistry. 2007.
PMID: 17326665
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Mechanism of chorismate synthase. Role of the two invariant histidine residues in the active site.
Kitzing K, Auweter S, Amrhein N, Macheroux P.
Kitzing K, et al.
J Biol Chem. 2004 Mar 5;279(10):9451-61. doi: 10.1074/jbc.M312471200. Epub 2003 Dec 10.
J Biol Chem. 2004.
PMID: 14668332
Free article.
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