In DNA replication, the early bird catches the worm

Erik Boye; Beáta Grallert

doi:10.1016/j.cell.2009.02.023

In DNA replication, the early bird catches the worm

Cell. 2009 Mar 6;136(5):812-4. doi: 10.1016/j.cell.2009.02.023.

Authors

Erik Boye, Beáta Grallert

PMID: 19269359
DOI: 10.1016/j.cell.2009.02.023

Abstract

The initiation of DNA replication is a complex, multistep process with important implications for genomic stability. In this issue, Wu and Nurse (2009) find that initiation factors are differentially recruited to replication origins. They uncover evidence suggesting that the efficiency of this recruitment may determine whether and when an origin is used to initiate DNA replication in S phase.

Publication types

Editorial
Comment

MeSH terms

DNA Replication*
DNA, Fungal / genetics
Genomic Instability
Replication Origin
Schizosaccharomyces / cytology
Schizosaccharomyces / genetics
Schizosaccharomyces / metabolism*
Schizosaccharomyces pombe Proteins / metabolism

Substances

DNA, Fungal
Schizosaccharomyces pombe Proteins