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1978 1
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990 results

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Page 1
Psychedelics as anti-inflammatory agents.
Flanagan TW, Nichols CD. Flanagan TW, et al. Int Rev Psychiatry. 2018 Aug;30(4):363-375. doi: 10.1080/09540261.2018.1481827. Epub 2018 Aug 13. Int Rev Psychiatry. 2018. PMID: 30102081
This review discusses the role of the 5-HT(2A) receptor in the inflammatory response, as well as highlight studies using the 5-HT(2A) agonist (R)-2,5-dimethoxy-4-iodoamphetamine [(R)-DOI] to treat inflammation in cellular and animal models. ...
This review discusses the role of the 5-HT(2A) receptor in the inflammatory response, as well as highlight studies using the 5-HT(2A) agonis …
2,5-Dimethoxy-4-iodoamphetamine and altanserin induce region-specific shifts in dopamine and serotonin metabolization pathways in the rat brain.
Nikolaus S, Fazari B, Chao OY, Almeida FR, Abdel-Hafiz L, Beu M, Henke J, Antke C, Hautzel H, Mamlins E, Müller HW, Huston JP, von Gall C, Giesel FL. Nikolaus S, et al. Pharmacol Biochem Behav. 2024 Sep;242:173823. doi: 10.1016/j.pbb.2024.173823. Epub 2024 Jul 11. Pharmacol Biochem Behav. 2024. PMID: 39002804 Free article.
In the present study, we assessed the effects of the 5-HT(2A) receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) and the 5-HT(2A) receptor altanserin (ALT) on object and place recognition memory and cerebral neurotransmitters and metabolites …
In the present study, we assessed the effects of the 5-HT(2A) receptor agonist 2,5-dimethoxy-4-iodoamphetamin …
Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model.
Canal CE, Morgan D. Canal CE, et al. Drug Test Anal. 2012 Jul-Aug;4(7-8):556-76. doi: 10.1002/dta.1333. Epub 2012 Apr 19. Drug Test Anal. 2012. PMID: 22517680 Free PMC article. Review.
The substituted amphetamine hallucinogen, serotonin 2 (5-HT(2) ) receptor agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI) has emerged as the most popular pharmacological tool used in HTR studies of hallucinogens. ...
The substituted amphetamine hallucinogen, serotonin 2 (5-HT(2) ) receptor agonist, 2,5-dimethoxy-4-iodoamphet …
The hallucinogen 2,5-dimethoxy-4-iodoamphetamine hydrochloride activates neurotrophin receptors in a neuronal cell line and promotes neurites extension.
Marinova Z, Walitza S, Grünblatt E. Marinova Z, et al. J Neural Transm (Vienna). 2017 Jun;124(6):749-759. doi: 10.1007/s00702-017-1706-y. Epub 2017 Mar 18. J Neural Transm (Vienna). 2017. PMID: 28315978
We have previously identified the hallucinogen 2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) as protective against trophic deprivation-induced cytotoxicity in human neuroblastoma SK-N-SH cells and established the dependence of this effect …
We have previously identified the hallucinogen 2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) as pro …
Age-related loss of responsiveness to 2,5-dimethoxy-4-iodoamphetamine in liver sinusoidal endothelial cells.
Cogger VC, Mitchell SJ, Warren A, de Cabo R, Le Couteur DG. Cogger VC, et al. J Gerontol A Biol Sci Med Sci. 2014 May;69(5):514-8. doi: 10.1093/gerona/glt124. Epub 2013 Aug 23. J Gerontol A Biol Sci Med Sci. 2014. PMID: 23974079 Free PMC article.
Here, we have assessed whether 2,5-dimethoxy-4-iodoamphetamine influences ultrastructure of the sinusoidal endothelium in normal 7- and 24-month-old C57Bl6 mice. Following 48 hours of 2,5-dimethoxy-4-iodoamphetamin …
Here, we have assessed whether 2,5-dimethoxy-4-iodoamphetamine influences ultrastructure of the sinusoida …
2,5-Dimethoxy-4-iodoamphetamine (DOI) inhibits Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice.
Egashira N, Koushi E, Mishima K, Iwasaki K, Oishi R, Fujiwara M. Egashira N, et al. J Pharmacol Sci. 2007 Dec;105(4):361-6. doi: 10.1254/jphs.fp0071247. Epub 2007 Dec 1. J Pharmacol Sci. 2007. PMID: 18057774 Free article.
The effect of the serotonin 5-HT(2A/2C)-receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) on Delta(9)-tetrahydrocannabinol (THC)-induced catalepsy-like immobilization was studied in mice. ...
The effect of the serotonin 5-HT(2A/2C)-receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) on Delta(9 …
Effects of 5-HT2A receptor agonist 2,5-dimethoxy-4-iodoamphetamine on alcohol consumption in Long-Evans rats.
Berquist MD, Fantegrossi WE. Berquist MD, et al. Behav Pharmacol. 2021 Aug 1;32(5):382-391. doi: 10.1097/FBP.0000000000000628. Behav Pharmacol. 2021. PMID: 33595958 Free PMC article.
The objectives of this study were to determine alcohol consumption after administration of (R)(-)-2,5-dimethoxy-4-iodoamphetamine (DOI) or naltrexone in Long-Evans rats, and to assess the effectiveness of these treatments based on individual dif …
The objectives of this study were to determine alcohol consumption after administration of (R)(-)-2,5-dimethoxy-4 …
Lasting dynamic effects of the psychedelic 2,5-dimethoxy-4-iodoamphetamine (()-DOI) on cognitive flexibility.
Šabanović M, Lazari A, Blanco-Pozo M, Tisca C, Tachrount M, Martins-Bach AB, Lerch JP, Walton ME, Bannerman DM. Šabanović M, et al. Mol Psychiatry. 2024 Jun;29(6):1810-1823. doi: 10.1038/s41380-024-02439-2. Epub 2024 Feb 7. Mol Psychiatry. 2024. PMID: 38321122 Free PMC article.
Here we show that a single dose of the psychedelic 2,5-dimethoxy-4-iodoamphetamine (()-DOI) affects structural brain plasticity and cognitive flexibility in young adult mice beyond the acute drug experience. ...
Here we show that a single dose of the psychedelic 2,5-dimethoxy-4-iodoamphetamine (()-DOI) affects struc …
Lactobacillus plantarum PS128 ameliorates 2,5-Dimethoxy-4-iodoamphetamine-induced tic-like behaviors via its influences on the microbiota-gut-brain-axis.
Liao JF, Cheng YF, Li SW, Lee WT, Hsu CC, Wu CC, Jeng OJ, Wang S, Tsai YC. Liao JF, et al. Brain Res Bull. 2019 Nov;153:59-73. doi: 10.1016/j.brainresbull.2019.07.027. Epub 2019 Jul 25. Brain Res Bull. 2019. PMID: 31351942
Here, we examine the possibility of using PS128 administration to improve tic-like behaviors by using a 5-HT(2A) and 5-HT(2C) receptor agonist 2,5-Dimethoxy-4-iodoamphetamine (DOI). PS128 was orally administered to male Wistar rat for 2 weeks be …
Here, we examine the possibility of using PS128 administration to improve tic-like behaviors by using a 5-HT(2A) and 5-HT(2C) receptor agoni …
Biological sex modulates the efficacy of 2,5-dimethoxy-4-iodoamphetamine (DOI) to mitigate fentanyl demand.
McQueney AJ, Garcia EJ. McQueney AJ, et al. Drug Alcohol Depend. 2024 Oct 1;263:112426. doi: 10.1016/j.drugalcdep.2024.112426. Epub 2024 Aug 25. Drug Alcohol Depend. 2024. PMID: 39217832
Here, we tested the hypothesis that the preferential serotonin 5-HT(2A)R agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI) could reduce the demand for fentanyl in a preclinical model of fentanyl self-administration. ...
Here, we tested the hypothesis that the preferential serotonin 5-HT(2A)R agonist, 2,5-dimethoxy-4-iodoampheta …
990 results