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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
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1981 1
1982 3
1983 2
1984 3
1985 2
1986 2
1987 4
1988 9
1989 9
1990 3
1991 2
1992 4
1993 3
1994 3
1995 2
1996 5
1997 5
1998 3
1999 2
2000 5
2001 6
2002 7
2003 4
2004 7
2005 8
2007 5
2008 3
2009 7
2010 7
2011 5
2012 10
2013 8
2014 7
2015 11
2016 3
2017 1
2018 6
2019 14
2020 7
2021 7
2022 6
2023 1
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198 results
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Page 1
Mechanism-based traps enable protease and hydrolase substrate discovery.
Tang S, Beattie AT, Kafkova L, Petris G, Huguenin-Dezot N, Fiedler M, Freeman M, Chin JW. Tang S, et al. Nature. 2022 Feb;602(7898):701-707. doi: 10.1038/s41586-022-04414-9. Epub 2022 Feb 16. Nature. 2022. PMID: 35173328 Free PMC article.
Hydrolase enzymes, including proteases, are encoded by 2-3% of the genes in the human genome and 14% of these enzymes are active drug targets(1). ...The traps capture substrates of hydrolases, which normally use a serine or cysteine nucleophile. Replacing the cataly …
Hydrolase enzymes, including proteases, are encoded by 2-3% of the genes in the human genome and 14% of these enzymes are acti …
Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid.
Huguenin-Dezot N, Alonzo DA, Heberlig GW, Mahesh M, Nguyen DP, Dornan MH, Boddy CN, Schmeing TM, Chin JW. Huguenin-Dezot N, et al. Nature. 2019 Jan;565(7737):112-117. doi: 10.1038/s41586-018-0781-z. Epub 2018 Dec 12. Nature. 2019. PMID: 30542153 Free PMC article.
Many enzymes catalyse reactions that proceed through covalent acyl-enzyme (ester or thioester) intermediates(1). These enzymes include serine hydrolases(2,3) (encoded by one per cent of human genes, and including serine proteases and thioesterases), cysteine proteas …
Many enzymes catalyse reactions that proceed through covalent acyl-enzyme (ester or thioester) intermediates(1). These enzymes include serin …
Mutation of L-2,3-diaminopropionic acid synthase genes blocks staphyloferrin B synthesis in Staphylococcus aureus.
Beasley FC, Cheung J, Heinrichs DE. Beasley FC, et al. BMC Microbiol. 2011 Sep 9;11:199. doi: 10.1186/1471-2180-11-199. BMC Microbiol. 2011. PMID: 21906287 Free PMC article.
Several mechanisms are proposed for how the enzymes SbnA, with similarity to cysteine synthase enzymes, and SbnB, with similarity to amino acid dehydrogenases and ornithine cyclodeaminases, function together in the synthesis of this unusual nonproteinogenic amino acid
Several mechanisms are proposed for how the enzymes SbnA, with similarity to cysteine synthase enzymes, and SbnB, with similarity to amino …
Analysis of neurotoxin 3-N-oxalyl-L-2,3-diaminopropionic acid and its alpha-isomer in Lathyrus sativus by high-performance liquid chromatography with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) derivatization.
Chen X, Wang F, Chen Q, Qin XC, Li Z. Chen X, et al. J Agric Food Chem. 2000 Aug;48(8):3383-6. doi: 10.1021/jf000033y. J Agric Food Chem. 2000. PMID: 10956120
A method was developed for the quantitative determination of the neurotoxic nonprotein amino acid, 3-N-oxalyl-L-2,3-diaminopropionic acid (beta-ODAP), and its nontoxic alpha-isomer, 2-N-oxalyl-L-2, 3-diaminopropion
A method was developed for the quantitative determination of the neurotoxic nonprotein amino acid, 3-N-oxalyl-L-2,3
Stereoselective α-Deuteration of Serine, Cysteine, Selenocysteine, and 2,3-Diaminopropanoic Acid Derivatives.
Navo CD, Oroz P, Mazo N, Blanco M, Peregrina JM, Jiménez-Osés G. Navo CD, et al. Org Lett. 2022 Sep 23;24(37):6810-6815. doi: 10.1021/acs.orglett.2c02715. Epub 2022 Sep 9. Org Lett. 2022. PMID: 36082943
Efficient methodologies for synthesizing enantiopure alpha-deuterated derivatives of serine, cysteine, selenocysteine, and 2,3-diaminopropanoic acid have been developed. H/D exchange was achieved by deprotonation of a chiral bicyclic serine equivalent followe …
Efficient methodologies for synthesizing enantiopure alpha-deuterated derivatives of serine, cysteine, selenocysteine, and 2,3
Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor.
Kobylarz MJ, Grigg JC, Takayama SJ, Rai DK, Heinrichs DE, Murphy ME. Kobylarz MJ, et al. Chem Biol. 2014 Mar 20;21(3):379-88. doi: 10.1016/j.chembiol.2013.12.011. Epub 2014 Jan 30. Chem Biol. 2014. PMID: 24485762
L-2,3-diaminopropionic acid (L-Dap) is an amino acid that is a precursor of antibiotics and staphyloferrin B a siderophore produced by Staphylococcus aureus. ...We demonstrate here that SbnA uses PLP and substrates O-phospho-L-serine and L-gluta …
L-2,3-diaminopropionic acid (L-Dap) is an amino acid that is a precursor of antibiotics and staphyloferri …
2,3-Diaminopropanols Obtained from d-Serine as Intermediates in the Synthesis of Protected 2,3-l-Diaminopropanoic Acid (l-Dap) Methyl Esters.
Temperini A, Aiello D, Mazzotti F, Athanassopoulos CM, De Luca P, Siciliano C. Temperini A, et al. Molecules. 2020 Mar 13;25(6):1313. doi: 10.3390/molecules25061313. Molecules. 2020. PMID: 32183079 Free PMC article.
A synthetic strategy for the preparation of two orthogonally protected methyl esters of the non-proteinogenic amino acid 2,3-l-diaminopropanoic acid (l-Dap) was developed. In these structures, the base-labile protecting group 9-fluorenylmethyloxycarbon …
A synthetic strategy for the preparation of two orthogonally protected methyl esters of the non-proteinogenic amino acid 2, …
New 2,3-diaminopropionic acid inhibitors of AGE and ALE formation.
Audic N, Potier G, Sasaki NA. Audic N, et al. Org Biomol Chem. 2013 Feb 7;11(5):773-80. doi: 10.1039/c2ob27084f. Epub 2012 Dec 17. Org Biomol Chem. 2013. PMID: 23242031
Novel 2,3-diaminopropionic acid-based molecules were synthesised and tested successfully as glyoxal/methylglyoxal scavengers and as AGE inhibitors. ...
Novel 2,3-diaminopropionic acid-based molecules were synthesised and tested successfully as glyoxal/methylglyoxa …
Novel Cell Permeable Polymers of N-Substituted L-2,3-Diaminopropionic Acid (DAPEGs) and Cellular Consequences of Their Interactions with Nucleic Acids.
Romanowska A, Węgrzyn K, Bury K, Sikorska E, Gnatek A, Piwkowska A, Konieczny I, Lesner A, Wysocka M. Romanowska A, et al. Int J Mol Sci. 2021 Mar 4;22(5):2571. doi: 10.3390/ijms22052571. Int J Mol Sci. 2021. PMID: 33806461 Free PMC article.
The present study aimed to synthesize novel polycationic polymers composed of N-substituted L-2,3-diaminopropionic acid residues (DAPEGs) and investigate their cell permeability, cytotoxicity, and DNA-binding ability. The most efficient cell membrane-p …
The present study aimed to synthesize novel polycationic polymers composed of N-substituted L-2,3-diaminopropionic a
Enzymes with noncanonical amino acids.
Zhao J, Burke AJ, Green AP. Zhao J, et al. Curr Opin Chem Biol. 2020 Apr;55:136-144. doi: 10.1016/j.cbpa.2020.01.006. Epub 2020 Mar 9. Curr Opin Chem Biol. 2020. PMID: 32163871 Review.
198 results