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Inflammation Biomarker Response to Oral 2-Hydroxybenzylamine (2-HOBA) Acetate in Healthy Humans.
Rathmacher JA, Fuller JC Jr, Abumrad NN, Flynn CR. Rathmacher JA, et al. Inflammation. 2023 Aug;46(4):1343-1352. doi: 10.1007/s10753-023-01801-w. Epub 2023 Mar 20. Inflammation. 2023. PMID: 36935449 Free PMC article.
The most reactive of these are the IsoLGs, which form covalent adducts with lysine residues and other cellular primary amines leading to changes in protein function, immunogenicity, and epigenetic alterations and have been shown to contribute to a number of inflammatory diseases. …
The most reactive of these are the IsoLGs, which form covalent adducts with lysine residues and other cellular primary amines leading to cha …
In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate.
Fuller JC Jr, Pitchford LM, Morrison RD, Daniels JS, Flynn CR, Abumrad NN, Oates JA, Boutaud O, Rathmacher JA. Fuller JC Jr, et al. Food Chem Toxicol. 2018 Nov;121:541-548. doi: 10.1016/j.fct.2018.09.047. Epub 2018 Sep 22. Food Chem Toxicol. 2018. PMID: 30253245 Free PMC article.
2-hydroxybenzylamine (2-HOBA), a compound found in buckwheat, is a potent scavenger of reactive gamma-ketoaldehydes, which are increased in diseases associated with inflammation and oxidative stress. ...The major metabolites identified were salicylic a …
2-hydroxybenzylamine (2-HOBA), a compound found in buckwheat, is a potent scavenger of reactive gamma-ketoaldehy …
Repetitive sulfur dioxide exposure in mice models post-deployment respiratory syndrome.
Gutor SS, Salinas RI, Nichols DS, Bazzano JMR, Han W, Gokey JJ, Vasiukov G, West JD, Newcomb DC, Dikalova AE, Richmond BW, Dikalov SI, Blackwell TS, Polosukhin VV. Gutor SS, et al. Am J Physiol Lung Cell Mol Physiol. 2024 May 1;326(5):L539-L550. doi: 10.1152/ajplung.00239.2023. Epub 2024 Feb 27. Am J Physiol Lung Cell Mol Physiol. 2024. PMID: 38410870 Free PMC article.
SO(2) exposure led to increased formation of isolevuglandins (isoLGs) adducts and superoxide dismutase 2 (SOD2) acetylation in endothelial cells, which were attenuated by treatment with the isoLG scavenger 2-hydroxybenzylamine acetate (2-HOBA). …
SO(2) exposure led to increased formation of isolevuglandins (isoLGs) adducts and superoxide dismutase 2 (SOD2) acetylation in endothelial c …
Subchronic (90-day) repeated dose toxicity study of 2-hydroxybenzylamine acetate in rats.
Fuller JC Jr, Pitchford LM, Abumrad NN, Rathmacher JA. Fuller JC Jr, et al. Regul Toxicol Pharmacol. 2018 Nov;99:225-232. doi: 10.1016/j.yrtph.2018.09.025. Epub 2018 Sep 25. Regul Toxicol Pharmacol. 2018. PMID: 30266239 Free article.
2-Hydroxybenzylamine (2-HOBA), a naturally occurring compound found in buckwheat, can protect cells and tissues from oxidative stress. ...These results further support no toxicity associated with oral consumption of 2-HOBA acetate …
2-Hydroxybenzylamine (2-HOBA), a naturally occurring compound found in buckwheat, can protect cells and tissues …
Subchronic (90-day) repeated dose oral toxicity study of 2-hydroxybenzylamine acetate in rabbit.
Fuller JC Jr, Pitchford LM, Abumrad NN, Rathmacher JA. Fuller JC Jr, et al. Regul Toxicol Pharmacol. 2018 Dec;100:52-58. doi: 10.1016/j.yrtph.2018.10.017. Epub 2018 Oct 22. Regul Toxicol Pharmacol. 2018. PMID: 30359704 Free article.
2-hydroxybenzylamine (2-HOBA), a naturally occurring compound found in buckwheat, has potential for use as a nutrition supplement due to its ability to protect against the damaging effects of oxidative stress. ...These results provide further support f …
2-hydroxybenzylamine (2-HOBA), a naturally occurring compound found in buckwheat, has potential for use as a nut …
Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial.
Pitchford LM, Driver PM, Fuller JC Jr, Akers WS, Abumrad NN, Amarnath V, Milne GL, Chen SC, Ye F, Roberts LJ 2nd, Shoemaker MB, Oates JA, Rathmacher JA, Boutaud O. Pitchford LM, et al. BMC Pharmacol Toxicol. 2020 Jan 6;21(1):3. doi: 10.1186/s40360-020-0382-y. BMC Pharmacol Toxicol. 2020. PMID: 31907026 Free PMC article. Clinical Trial.
BACKGROUND: 2-Hydroxybenzylamine (2-HOBA) is a selective dicarbonyl electrophile scavenger being developed as a nutritional supplement to help protect against the development of conditions associated with dicarbonyl electrophile formation, such as the …
BACKGROUND: 2-Hydroxybenzylamine (2-HOBA) is a selective dicarbonyl electrophile scavenger being developed as a …
First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers.
Pitchford LM, Rathmacher JA, Fuller JC Jr, Daniels JS, Morrison RD, Akers WS, Abumrad NN, Amarnath V, Currey PM, Roberts LJ, Oates JA, Boutaud O. Pitchford LM, et al. BMC Pharmacol Toxicol. 2019 Jan 5;20(1):1. doi: 10.1186/s40360-018-0281-7. BMC Pharmacol Toxicol. 2019. PMID: 30611293 Free PMC article. Clinical Trial.
BACKGROUND: 2-Hydroxybenzylamine (2-HOBA) is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles. ...METHODS: In this first-in-human study, the safety, tolerability, and pharmac …
BACKGROUND: 2-Hydroxybenzylamine (2-HOBA) is a selective scavenger of dicarbonyl electrophiles that protects pro …
Acute and 28-day repeated dose toxicity evaluations of 2-hydroxybenzylamine acetate in mice and rats.
Pitchford LM, Smith JD, Abumrad NN, Rathmacher JA, Fuller JC Jr. Pitchford LM, et al. Regul Toxicol Pharmacol. 2018 Oct;98:190-198. doi: 10.1016/j.yrtph.2018.07.026. Epub 2018 Jul 31. Regul Toxicol Pharmacol. 2018. PMID: 30075181 Free article.
2-hydroxybenzylamine (2-HOBA), a compound naturally found in buckwheat, has been shown to protect cells and tissues from the damaging effects of oxidative stress. ...Together, these studies support the lack of toxicity of oral administration of 2 …
2-hydroxybenzylamine (2-HOBA), a compound naturally found in buckwheat, has been shown to protect cells and tiss …
Reactive Dicarbonyl Scavenging with 2-Hydroxybenzylamine Improves MASH.
Cheung-Flynn J, Rathmacher JA, Pitchford LM, Xiong Y, Flynn CR. Cheung-Flynn J, et al. Nutrients. 2025 Feb 7;17(4):610. doi: 10.3390/nu17040610. Nutrients. 2025. PMID: 40004939 Free PMC article.
Reducing DE stress may be a potential strategy for managing MASLD. We hypothesized that the DE scavenger 2-hydroxybenzylamine (2-HOBA) would reduce liver injury by reducing liver protein adduct formation by DE in mouse models of MASLD. ...In STAM (Stel …
Reducing DE stress may be a potential strategy for managing MASLD. We hypothesized that the DE scavenger 2-hydroxybenzylamine …
Inflammation, immunity, and hypertensive end-organ damage.
McMaster WG, Kirabo A, Madhur MS, Harrison DG. McMaster WG, et al. Circ Res. 2015 Mar 13;116(6):1022-33. doi: 10.1161/CIRCRESAHA.116.303697. Circ Res. 2015. PMID: 25767287 Free PMC article. Review.
These studies have shown that stimuli like angiotensin II, deoxycorticosterone acetate-salt, and excessive catecholamines lead to formation of effector like T cells that infiltrate the kidney and perivascular regions of both large arteries and arterioles. ...
These studies have shown that stimuli like angiotensin II, deoxycorticosterone acetate-salt, and excessive catecholamines lead to for …