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1971 1
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1993 1
1996 1
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2009 1
2015 2
2016 2
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2018 5
2019 6
2020 10
2021 6
2022 4
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2-Hydroxybenzylamine (2-HOBA) to prevent early recurrence of atrial fibrillation after catheter ablation: protocol for a randomized controlled trial including detection of AF using a wearable device.
O'Neill MJ, Yoneda ZT, Crawford DM, Ye F, Ao M, Pitchford LM, Rathmacher JA, Murray KT, Akers WS, Roden DM, Michaud GF, Shoemaker MB. O'Neill MJ, et al. Trials. 2021 Aug 28;22(1):576. doi: 10.1186/s13063-021-05553-6. Trials. 2021. PMID: 34454591 Free PMC article.
Isolevuglandins (IsoLGs) are reactive lipid mediators of oxidative stress injury that rapidly react with endogenous biomolecules to compromise their function. 2-Hydroxybenzylamine (2-HOBA), a potent small molecule scavenger of IsoLGs, sequesters the reactive …
Isolevuglandins (IsoLGs) are reactive lipid mediators of oxidative stress injury that rapidly react with endogenous biomolecules to compromi …
Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr-/- mice.
Tao H, Huang J, Yancey PG, Yermalitsky V, Blakemore JL, Zhang Y, Ding L, Zagol-Ikapitte I, Ye F, Amarnath V, Boutaud O, Oates JA, Roberts LJ 2nd, Davies SS, Linton MF. Tao H, et al. Nat Commun. 2020 Aug 14;11(1):4084. doi: 10.1038/s41467-020-17915-w. Nat Commun. 2020. PMID: 32796843 Free PMC article.
Humans with familial hypercholesterolemia (FH) have increased lipoprotein dicarbonyl adducts and dysfunctional HDL. We investigate the impact of the dicarbonyl scavenger, 2-hydroxybenzylamine (2-HOBA) on HDL function and atherosclerosis in Ldlr(-/-) mice, a m …
Humans with familial hypercholesterolemia (FH) have increased lipoprotein dicarbonyl adducts and dysfunctional HDL. We investigate the impac …
Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis.
Gobert AP, Boutaud O, Asim M, Zagol-Ikapitte IA, Delgado AG, Latour YL, Finley JL, Singh K, Verriere TG, Allaman MM, Barry DP, McNamara KM, Sierra JC, Amarnath V, Tantawy MN, Bimczok D, Piazuelo MB, Washington MK, Zhao S, Coburn LA, Wilson KT. Gobert AP, et al. Gastroenterology. 2021 Mar;160(4):1256-1268.e9. doi: 10.1053/j.gastro.2020.11.006. Epub 2020 Nov 13. Gastroenterology. 2021. PMID: 33189701 Free PMC article.
The effect on cancer development of a potent scavenger of dicarbonyl electrophiles, 5-ethyl-2-hydroxybenzylamine (EtHOBA), was determined in transgenic FVB/N insulin-gastrin (INS-GAS) mice and Mongolian gerbils as models of H pylori-induced carcinogenesis and in C57 …
The effect on cancer development of a potent scavenger of dicarbonyl electrophiles, 5-ethyl-2-hydroxybenzylamine (EtHOBA), was …
Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial.
Pitchford LM, Driver PM, Fuller JC Jr, Akers WS, Abumrad NN, Amarnath V, Milne GL, Chen SC, Ye F, Roberts LJ 2nd, Shoemaker MB, Oates JA, Rathmacher JA, Boutaud O. Pitchford LM, et al. BMC Pharmacol Toxicol. 2020 Jan 6;21(1):3. doi: 10.1186/s40360-020-0382-y. BMC Pharmacol Toxicol. 2020. PMID: 31907026 Free PMC article. Clinical Trial.
BACKGROUND: 2-Hydroxybenzylamine (2-HOBA) is a selective dicarbonyl electrophile scavenger being developed as a nutritional supplement to help protect against the development of conditions associated with dicarbonyl electrophile formation, such as the cogniti …
BACKGROUND: 2-Hydroxybenzylamine (2-HOBA) is a selective dicarbonyl electrophile scavenger being developed as a nutriti …
In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate.
Fuller JC Jr, Pitchford LM, Morrison RD, Daniels JS, Flynn CR, Abumrad NN, Oates JA, Boutaud O, Rathmacher JA. Fuller JC Jr, et al. Food Chem Toxicol. 2018 Nov;121:541-548. doi: 10.1016/j.fct.2018.09.047. Epub 2018 Sep 22. Food Chem Toxicol. 2018. PMID: 30253245 Free PMC article.
2-hydroxybenzylamine (2-HOBA), a compound found in buckwheat, is a potent scavenger of reactive gamma-ketoaldehydes, which are increased in diseases associated with inflammation and oxidative stress. ...The major metabolites identified were salicylic acid and
2-hydroxybenzylamine (2-HOBA), a compound found in buckwheat, is a potent scavenger of reactive gamma-ketoaldehydes, wh
Inflammation, immunity, and hypertensive end-organ damage.
McMaster WG, Kirabo A, Madhur MS, Harrison DG. McMaster WG, et al. Circ Res. 2015 Mar 13;116(6):1022-33. doi: 10.1161/CIRCRESAHA.116.303697. Circ Res. 2015. PMID: 25767287 Free PMC article. Review.
Salts of 2-hydroxybenzylamine with improvements on solubility and stability: Virtual and experimental screening.
Li J, Wu D, Xiao Y, Li C, Ji X, Sun Q, Chang D, Zhou L, Jing D, Gong J, Chen W. Li J, et al. Eur J Pharm Sci. 2022 Feb 1;169:106091. doi: 10.1016/j.ejps.2021.106091. Epub 2021 Dec 5. Eur J Pharm Sci. 2022. PMID: 34875374 Free article.
2-Hydroxybenzylamine (2-HOBA) is a drug used to effectively treat oxidative stress. ...All of them were salts and exhibited higher decomposition temperatures compared with pure 2-HOBA. The apparent aqueous solubility of three new salts, i.e., those wit
2-Hydroxybenzylamine (2-HOBA) is a drug used to effectively treat oxidative stress. ...All of them were salts and exhib
Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease.
Bowroju SK, Penthala NR, Lakkaniga NR, Balasubramaniam M, Ayyadevara S, Shmookler Reis RJ, Crooks PA. Bowroju SK, et al. Bioorg Med Chem. 2021 Sep 1;45:116311. doi: 10.1016/j.bmc.2021.116311. Epub 2021 Jul 14. Bioorg Med Chem. 2021. PMID: 34304133
A series of novel 2-hydroxybenzylamine-deoxyvasicinone hybrid analogs (8a-8n) have been synthesized and evaluated as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and as inhibitors of amyloid peptide (Abeta(1-42)) aggregation, for trea …
A series of novel 2-hydroxybenzylamine-deoxyvasicinone hybrid analogs (8a-8n) have been synthesized and evaluated as inhibitor …
First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers.
Pitchford LM, Rathmacher JA, Fuller JC Jr, Daniels JS, Morrison RD, Akers WS, Abumrad NN, Amarnath V, Currey PM, Roberts LJ, Oates JA, Boutaud O. Pitchford LM, et al. BMC Pharmacol Toxicol. 2019 Jan 5;20(1):1. doi: 10.1186/s40360-018-0281-7. BMC Pharmacol Toxicol. 2019. PMID: 30611293 Free PMC article. Clinical Trial.
BACKGROUND: 2-Hydroxybenzylamine (2-HOBA) is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles. ...RESULTS: Reported adverse events were mild and considered unlikely to be related to …
BACKGROUND: 2-Hydroxybenzylamine (2-HOBA) is a selective scavenger of dicarbonyl electrophiles that protects proteins a …
Subchronic (90-day) repeated dose oral toxicity study of 2-hydroxybenzylamine acetate in rabbit.
Fuller JC Jr, Pitchford LM, Abumrad NN, Rathmacher JA. Fuller JC Jr, et al. Regul Toxicol Pharmacol. 2018 Dec;100:52-58. doi: 10.1016/j.yrtph.2018.10.017. Epub 2018 Oct 22. Regul Toxicol Pharmacol. 2018. PMID: 30359704 Free article.
2-hydroxybenzylamine (2-HOBA), a naturally occurring compound found in buckwheat, has potential for use as a nutrition supplement due to its ability to protect against the damaging effects of oxidative stress. ...These results provide further support for the
2-hydroxybenzylamine (2-HOBA), a naturally occurring compound found in buckwheat, has potential for use as a nutrition
41 results