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1973 1
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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.
Fu X, Chin RM, Vergnes L, Hwang H, Deng G, Xing Y, Pai MY, Li S, Ta L, Fazlollahi F, Chen C, Prins RM, Teitell MA, Nathanson DA, Lai A, Faull KF, Jiang M, Clarke SG, Cloughesy TF, Graeber TG, Braas D, Christofk HR, Jung ME, Reue K, Huang J. Fu X, et al. Cell Metab. 2015 Sep 1;22(3):508-15. doi: 10.1016/j.cmet.2015.06.009. Epub 2015 Jul 16. Cell Metab. 2015. PMID: 26190651 Free PMC article.
We discovered recently that the central metabolite alpha-ketoglutarate (alpha-KG) extends the lifespan of C. elegans through inhibition of ATP synthase and TOR signaling. ...(R)-2HG accumulates in human cancers carrying neomorphic mutations in t …
We discovered recently that the central metabolite alpha-ketoglutarate (alpha-KG) extends the lifespan of C. elegans through …
D-2-Hydroxyglutarate and L-2-Hydroxyglutarate Inhibit IL-12 Secretion by Human Monocyte-Derived Dendritic Cells.
Ugele I, Cárdenas-Conejo ZE, Hammon K, Wehrstein M, Bruss C, Peter K, Singer K, Gottfried E, Boesch J, Oefner P, Dettmer K, Renner K, Kreutz M. Ugele I, et al. Int J Mol Sci. 2019 Feb 10;20(3):742. doi: 10.3390/ijms20030742. Int J Mol Sci. 2019. PMID: 30744183 Free PMC article.
Mutations in isocitrate dehydrogenase (IDH) or a reduced expression of L-2-hydroxyglutarate (HG)-dehydrogenase result in accumulation of D-2-HG or L-2-HG, respectively, in tumor tissues. ...Addition of the ATP synthase inhibitor oligomyci …
Mutations in isocitrate dehydrogenase (IDH) or a reduced expression of L-2-hydroxyglutarate (HG)-dehydrogenase result in accum …
Regulation of the mitochondrial ATP-synthase in health and disease.
Das AM. Das AM. Mol Genet Metab. 2003 Jun;79(2):71-82. doi: 10.1016/s1096-7192(03)00069-6. Mol Genet Metab. 2003. PMID: 12809636 Review.
In most tissues the mitochondrial ATP-synthase plays a central role by synthesizing the bulk of ATP. ...Cells can be rescued by adding creatine to the incubation medium. In D-2-hydroxyglutaric aciduria, inhibition of the ATP-synthase …
In most tissues the mitochondrial ATP-synthase plays a central role by synthesizing the bulk of ATP. ...Cells can be re …
Metabolic regulation of cholestatic liver injury by D-2-hydroxyglutarate with the modulation of hepatic microenvironment and the mammalian target of rapamycin signaling.
Tian X, Wang Y, Lu Y, Wu B, Chen S, Du J, Cai W, Xiao Y. Tian X, et al. Cell Death Dis. 2022 Nov 26;13(11):1001. doi: 10.1038/s41419-022-05450-z. Cell Death Dis. 2022. PMID: 36435860 Free PMC article.
The energy metabolism analysis demonstrated that D-2-HG inhibited mitochondrial respiration and ATP synthase; however, it increased aerobic glycolysis in organoids. In addition, D-2-HG exposure caused liver degeneration in zebrafish larvae. Mech …
The energy metabolism analysis demonstrated that D-2-HG inhibited mitochondrial respiration and ATP synthase; ho …
The Role of Mitochondrial H+-ATP Synthase in Cancer.
Esparza-Moltó PB, Cuezva JM. Esparza-Moltó PB, et al. Front Oncol. 2018 Mar 7;8:53. doi: 10.3389/fonc.2018.00053. eCollection 2018. Front Oncol. 2018. PMID: 29564224 Free PMC article. Review.
Consistently, IF1 expression is an independent marker of cancer prognosis. By contrast, inhibition of the H(+)-ATP synthase by alpha-ketoglutarate and the oncometabolite 2-hydroxyglutarate, reduces mTOR signaling, suppresses cancer cell g …
Consistently, IF1 expression is an independent marker of cancer prognosis. By contrast, inhibition of the H(+)-ATP synthase …
Microbial metabolism of amino alcohols. 1-Aminopropan-2-ol and ethanolamine metabolism via propionaldehyde and acetaldehyde in a species of Pseudomonas.
Jones A, Turner JM. Jones A, et al. Biochem J. 1973 May;134(1):167-82. doi: 10.1042/bj1340167. Biochem J. 1973. PMID: 4723219 Free PMC article.
P6, was capable of growth on both stereoisomers of 1-aminopropan-2-ol, and supported the hypothesis that assimilation involved metabolism to propionaldehyde, propionate and possibly 2-hydroxyglutarate. ...Propionate and acetate were concluded to be metabolize …
P6, was capable of growth on both stereoisomers of 1-aminopropan-2-ol, and supported the hypothesis that assimilation involved metabo …
Mitochondrial energy metabolism is markedly impaired by D-2-hydroxyglutaric acid in rat tissues.
Latini A, da Silva CG, Ferreira GC, Schuck PF, Scussiato K, Sarkis JJ, Dutra Filho CS, Wyse AT, Wannmacher CM, Wajner M. Latini A, et al. Mol Genet Metab. 2005 Sep-Oct;86(1-2):188-99. doi: 10.1016/j.ymgme.2005.05.002. Epub 2005 Jun 15. Mol Genet Metab. 2005. PMID: 15963747
Tissue accumulation of high amounts of D-2-hydroxyglutaric acid (DGA) and l-2-hydroxyglutaric acid (LGA) is the biochemical hallmark of the inherited neurometabolic disorders D-2-hydroxyglutaric aciduria (DHGA) and l-2-hydroxyglutaric aciduria (LHGA), …
Tissue accumulation of high amounts of D-2-hydroxyglutaric acid (DGA) and l-2-hydroxyglutaric acid (LGA) is the biochemical ha …
NMDA receptor activation and respiratory chain complex V inhibition contribute to neurodegeneration in d-2-hydroxyglutaric aciduria.
Kölker S, Pawlak V, Ahlemeyer B, Okun JG, Hörster F, Mayatepek E, Krieglstein J, Hoffmann GF, Köhr G. Kölker S, et al. Eur J Neurosci. 2002 Jul;16(1):21-8. doi: 10.1046/j.1460-9568.2002.02055.x. Eur J Neurosci. 2002. PMID: 12153528
Here, we report that the pathogenetic role of the endogenously accumulating metabolite d-2-hydroxyglutarate (D-2), which is structurally similar to the excitatory amino acid glutamate, is mediated by at least three mechanisms. ...(iii) D-2 reduced comp …
Here, we report that the pathogenetic role of the endogenously accumulating metabolite d-2-hydroxyglutarate (D-2), whic …