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1,060 results

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Page 1
2-Oxoglutarate-Dependent Oxygenases.
Islam MS, Leissing TM, Chowdhury R, Hopkinson RJ, Schofield CJ. Islam MS, et al. Annu Rev Biochem. 2018 Jun 20;87:585-620. doi: 10.1146/annurev-biochem-061516-044724. Epub 2018 Mar 1. Annu Rev Biochem. 2018. PMID: 29494239 Review.
2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range of oxidative reactions. ...
2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range of oxidative reactions. .. …
2-Oxoglutarate-dependent dioxygenases in cancer.
Losman JA, Koivunen P, Kaelin WG Jr. Losman JA, et al. Nat Rev Cancer. 2020 Dec;20(12):710-726. doi: 10.1038/s41568-020-00303-3. Epub 2020 Oct 21. Nat Rev Cancer. 2020. PMID: 33087883 Review.
2-Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play diverse roles in many biological processes, including regulation of hypoxia-inducible factor-mediated adaptation to hypoxia, extracellular matrix formation, epigenetic regul …
2-Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play diverse roles in many biological …
Exploring links between 2-oxoglutarate-dependent oxygenases and Alzheimer's disease.
Liu H, Xie Y, Wang X, Abboud MI, Ma C, Ge W, Schofield CJ. Liu H, et al. Alzheimers Dement. 2022 Dec;18(12):2637-2668. doi: 10.1002/alz.12733. Epub 2022 Jul 19. Alzheimers Dement. 2022. PMID: 35852137 Free PMC article. Review.
Hypoxia, that is, an inadequate oxygen supply, is linked to neurodegeneration and patients with cardiovascular disease are prone to Alzheimer's disease (AD). 2-Oxoglutarate and ferrous iron-dependent oxygenases (2OGDD) play a key role in the regulation …
Hypoxia, that is, an inadequate oxygen supply, is linked to neurodegeneration and patients with cardiovascular disease are prone to Alzheime …
Human 2-oxoglutarate-dependent oxygenases: nutrient sensors, stress responders, and disease mediators.
Fletcher SC, Coleman ML. Fletcher SC, et al. Biochem Soc Trans. 2020 Oct 30;48(5):1843-1858. doi: 10.1042/BST20190333. Biochem Soc Trans. 2020. PMID: 32985654 Free PMC article. Review.
Fe(II)/2-oxoglutarate (2OG)-dependent oxygenases are a conserved enzyme class that catalyse diverse oxidative reactions across nature. ...In this review, we focus on human 2OG-dependent oxygenases catalysing the hydroxylation of protein a …
Fe(II)/2-oxoglutarate (2OG)-dependent oxygenases are a conserved enzyme class that catalyse diverse oxidative re …
Spectroscopic analyses of 2-oxoglutarate-dependent oxygenases: TauD as a case study.
Proshlyakov DA, McCracken J, Hausinger RP. Proshlyakov DA, et al. J Biol Inorg Chem. 2017 Apr;22(2-3):367-379. doi: 10.1007/s00775-016-1406-3. Epub 2016 Nov 3. J Biol Inorg Chem. 2017. PMID: 27812832 Free PMC article. Review.
A wide range of spectroscopic approaches have been used to interrogate the mononuclear iron metallocenter in 2-oxoglutarate (2OG)-dependent oxygenases. The results from these spectroscopic studies have provided valuable insights into the structural cha …
A wide range of spectroscopic approaches have been used to interrogate the mononuclear iron metallocenter in 2-oxoglutarate (2 …
Expanding the roles for 2-oxoglutarate-dependent oxygenases in plant metabolism.
Hagel JM, Facchini PJ. Hagel JM, et al. Nat Prod Rep. 2018 Aug 15;35(8):721-734. doi: 10.1039/c7np00060j. Nat Prod Rep. 2018. PMID: 29488530 Review.
Covering: up to 2018 2-Oxoglutarate-dependent oxygenases (2ODOs) comprise a large enzyme superfamily in plant genomes, second in size only to the cytochromes P450 monooxygenase (CYP) superfamily. 2ODOs participate in both primary and specialized plant …
Covering: up to 2018 2-Oxoglutarate-dependent oxygenases (2ODOs) comprise a large enzyme superfamily in plant ge …
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases.
Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, Ito S, Yang C, Wang P, Xiao MT, Liu LX, Jiang WQ, Liu J, Zhang JY, Wang B, Frye S, Zhang Y, Xu YH, Lei QY, Guan KL, Zhao SM, Xiong Y. Xu W, et al. Cancer Cell. 2011 Jan 18;19(1):17-30. doi: 10.1016/j.ccr.2010.12.014. Cancer Cell. 2011. PMID: 21251613 Free PMC article.
Here we demonstrate that 2-HG is a competitive inhibitor of multiple alpha-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases. 2-HG occupies the same space as alpha-KG does in the active site of histone demet …
Here we demonstrate that 2-HG is a competitive inhibitor of multiple alpha-KG-dependent dioxygenases, including histone demethylases …
Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases.
Markolovic S, Wilkins SE, Schofield CJ. Markolovic S, et al. J Biol Chem. 2015 Aug 21;290(34):20712-20722. doi: 10.1074/jbc.R115.662627. Epub 2015 Jul 7. J Biol Chem. 2015. PMID: 26152730 Free PMC article. Review.
The post-translational hydroxylation of prolyl and lysyl residues, as catalyzed by 2-oxoglutarate (2OG)-dependent oxygenases, was first identified in collagen biosynthesis. 2OG oxygenases also catalyze prolyl and asparaginyl hydroxylation of the …
The post-translational hydroxylation of prolyl and lysyl residues, as catalyzed by 2-oxoglutarate (2OG)-dependent ox …
Inhibition of 2-oxoglutarate dependent oxygenases.
Rose NR, McDonough MA, King ON, Kawamura A, Schofield CJ. Rose NR, et al. Chem Soc Rev. 2011 Aug;40(8):4364-97. doi: 10.1039/c0cs00203h. Epub 2011 Mar 10. Chem Soc Rev. 2011. PMID: 21390379 Review.
2-Oxoglutarate (2OG) dependent oxygenases are ubiquitous iron enzymes that couple substrate oxidation to the conversion of 2OG to succinate and carbon dioxide. ...In this critical review, we describe studies on the inhibition of 2OG oxygenases, …
2-Oxoglutarate (2OG) dependent oxygenases are ubiquitous iron enzymes that couple substrate oxidation to the con …
Catalytic Mechanisms of Fe(II)- and 2-Oxoglutarate-dependent Oxygenases.
Martinez S, Hausinger RP. Martinez S, et al. J Biol Chem. 2015 Aug 21;290(34):20702-20711. doi: 10.1074/jbc.R115.648691. Epub 2015 Jul 7. J Biol Chem. 2015. PMID: 26152721 Free PMC article. Review.
Mononuclear non-heme Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenases comprise a large family of enzymes that utilize an Fe(IV)-oxo intermediate to initiate diverse oxidative transformations with important biological roles. Here, four of the major …
Mononuclear non-heme Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenases comprise a large family of enzymes th …
1,060 results