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1919 1
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1946 7
1947 12
1948 12
1949 9
1950 5
1951 14
1952 12
1953 20
1954 16
1955 13
1956 19
1957 9
1958 6
1959 13
1960 19
1961 20
1962 27
1963 29
1964 30
1965 48
1966 59
1967 92
1968 117
1969 114
1970 128
1971 157
1972 194
1973 236
1974 256
1975 951
1976 1087
1977 1097
1978 1208
1979 1411
1980 1613
1981 1871
1982 1984
1983 2635
1984 2894
1985 3318
1986 3696
1987 4258
1988 4674
1989 6075
1990 6611
1991 7557
1992 8359
1993 9570
1994 10787
1995 12249
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1997 15111
1998 16971
1999 19121
2000 21981
2001 24363
2002 27215
2003 30938
2004 36176
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2006 45873
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2008 55930
2009 60582
2010 69651
2011 79169
2012 88163
2013 96379
2014 104778
2015 113253
2016 120160
2017 127256
2018 135299
2019 146157
2020 169218
2021 190212
2022 192402
2023 188874
2024 211456
2025 235067
2026 1242
2027 2

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2,539,560 results

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The following term was not found in PubMed: 20056724
Page 1
Target and tissue selectivity of PROTAC degraders.
Guenette RG, Yang SW, Min J, Pei B, Potts PR. Guenette RG, et al. Chem Soc Rev. 2022 Jul 18;51(14):5740-5756. doi: 10.1039/d2cs00200k. Chem Soc Rev. 2022. PMID: 35587208 Review.
Targeted protein degradation (TPD) strategies have revolutionized how scientists tackle challenging protein targets deemed undruggable with traditional small molecule inhibitors. Many promising campaigns to inhibit proteins have failed due to factors surrounding inh …
Targeted protein degradation (TPD) strategies have revolutionized how scientists tackle challenging protein targets deemed und …
Emerging Targets in Non-Small Cell Lung Cancer.
Liu L, Soler J, Reckamp KL, Sankar K. Liu L, et al. Int J Mol Sci. 2024 Sep 18;25(18):10046. doi: 10.3390/ijms251810046. Int J Mol Sci. 2024. PMID: 39337530 Free PMC article. Review.
New molecular drivers continue to emerge as promising therapeutic targets, including KRAS non-G12C, RAF/MEK, HER3, Nectin-4, folate receptor alpha, ITGB6, and PRMT5. In this review, we summarize the emerging molecular targets with a potential clinical impact in adva …
New molecular drivers continue to emerge as promising therapeutic targets, including KRAS non-G12C, RAF/MEK, HER3, Nectin-4, folate r …
Chasing molecular glue degraders: screening approaches.
Domostegui A, Nieto-Barrado L, Perez-Lopez C, Mayor-Ruiz C. Domostegui A, et al. Chem Soc Rev. 2022 Jul 4;51(13):5498-5517. doi: 10.1039/d2cs00197g. Chem Soc Rev. 2022. PMID: 35723413 Review.
In particular, molecular glue degraders are monovalent compounds that orchestrate interactions between a target protein and an E3 ubiquitin ligase, prompting the proteasomal degradation of the former. This and other pharmacological strategies of targeted protein deg …
In particular, molecular glue degraders are monovalent compounds that orchestrate interactions between a target protein and an E3 ubi …
The Osteosarcoma Microenvironment: A Complex But Targetable Ecosystem.
Corre I, Verrecchia F, Crenn V, Redini F, Trichet V. Corre I, et al. Cells. 2020 Apr 15;9(4):976. doi: 10.3390/cells9040976. Cells. 2020. PMID: 32326444 Free PMC article. Review.
Consequently, efforts to improve treatments using targeted therapies have faced this lack of specific osteosarcoma targets. Nevertheless, these tumors are inextricably linked to their local microenvironment, composed of bone, stromal, vascular and immune cells and t …
Consequently, efforts to improve treatments using targeted therapies have faced this lack of specific osteosarcoma targets. Ne …
Genome engineering with zinc-finger nucleases.
Carroll D. Carroll D. Genetics. 2011 Aug;188(4):773-82. doi: 10.1534/genetics.111.131433. Genetics. 2011. PMID: 21828278 Free PMC article. Review.
Zinc-finger nucleases (ZFNs) are targetable DNA cleavage reagents that have been adopted as gene-targeting tools. ZFN-induced double-strand breaks are subject to cellular DNA repair processes that lead to both targeted mutagenesis and targeted gene rep …
Zinc-finger nucleases (ZFNs) are targetable DNA cleavage reagents that have been adopted as gene-targeting tools. ZFN-induced …
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy.
Tang T, Huang X, Zhang G, Hong Z, Bai X, Liang T. Tang T, et al. Signal Transduct Target Ther. 2021 Feb 20;6(1):72. doi: 10.1038/s41392-020-00449-4. Signal Transduct Target Ther. 2021. PMID: 33608497 Free PMC article. Review.
More importantly, we highlight the critical role of tumor immune microenvironment regulators in tumor immune surveillance, immunological evasion, and the potential for their further translation into clinical practice. Based on their general targetability in clinical therap …
More importantly, we highlight the critical role of tumor immune microenvironment regulators in tumor immune surveillance, immunological eva …
Synthetic Lethality in Cancer Therapeutics: The Next Generation.
Setton J, Zinda M, Riaz N, Durocher D, Zimmermann M, Koehler M, Reis-Filho JS, Powell SN. Setton J, et al. Cancer Discov. 2021 Jul;11(7):1626-1635. doi: 10.1158/2159-8290.CD-20-1503. Epub 2021 Apr 1. Cancer Discov. 2021. PMID: 33795234 Free PMC article. Review.
Recent technological advances have led to an inflection point in our understanding of genetic interaction networks and ability to identify a wide array of novel SL drug targets. Here, we review concepts and lessons emerging from first-generation trials aimed at testing SL …
Recent technological advances have led to an inflection point in our understanding of genetic interaction networks and ability to identify a …
Targeting the undruggables-the power of protein degraders.
Zhang C, Liu Y, Li G, Yang Z, Han C, Sun X, Sheng C, Ding K, Rao Y. Zhang C, et al. Sci Bull (Beijing). 2024 Jun 15;69(11):1776-1797. doi: 10.1016/j.scib.2024.03.056. Epub 2024 Mar 29. Sci Bull (Beijing). 2024. PMID: 38614856 Free article. Review.
Undruggable targets typically refer to a class of therapeutic targets that are difficult to target through conventional methods or have not yet been targeted, but are of great clinical significance. ...Among them, targeted protein degradation te …
Undruggable targets typically refer to a class of therapeutic targets that are difficult to target through conventional …
Electrophilic warheads in covalent drug discovery: an overview.
Péczka N, Orgován Z, Ábrányi-Balogh P, Keserű GM. Péczka N, et al. Expert Opin Drug Discov. 2022 Apr;17(4):413-422. doi: 10.1080/17460441.2022.2034783. Epub 2022 Feb 6. Expert Opin Drug Discov. 2022. PMID: 35129005 Review.
The warheads are discussed by targeted residues, mechanism and selectivity, and analyzed through three different datasets including our collection of warheads, the CovPDB database, and the FDA approved covalent drugs. ...However, versatile, selective warheads are not avail …
The warheads are discussed by targeted residues, mechanism and selectivity, and analyzed through three different datasets including o …
Biomarkers and targeted therapy for cancer stem cells.
Liu Y, Wang H. Liu Y, et al. Trends Pharmacol Sci. 2024 Jan;45(1):56-66. doi: 10.1016/j.tips.2023.11.006. Epub 2023 Dec 9. Trends Pharmacol Sci. 2024. PMID: 38071088 Free PMC article. Review.
For these reasons, extensive efforts have been made to identify and target CSCs to potentially improve the antitumor efficacy of therapeutics. While progress has been made to uncover certain CSC-associated biomarkers, the identification of CSC-specific markers, especially …
For these reasons, extensive efforts have been made to identify and target CSCs to potentially improve the antitumor efficacy of ther …
2,539,560 results
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