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The metabolic growth limitations of petite cells lacking the mitochondrial genome.
Vowinckel J, Hartl J, Marx H, Kerick M, Runggatscher K, Keller MA, Mülleder M, Day J, Weber M, Rinnerthaler M, Yu JSL, Aulakh SK, Lehmann A, Mattanovich D, Timmermann B, Zhang N, Dunn CD, MacRae JI, Breitenbach M, Ralser M. Vowinckel J, et al. Nat Metab. 2021 Nov;3(11):1521-1535. doi: 10.1038/s42255-021-00477-6. Epub 2021 Nov 18. Nat Metab. 2021. PMID: 34799698 Free PMC article.
Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism.
Olin-Sandoval V, Yu JSL, Miller-Fleming L, Alam MT, Kamrad S, Correia-Melo C, Haas R, Segal J, Peña Navarro DA, Herrera-Dominguez L, Méndez-Lucio O, Vowinckel J, Mülleder M, Ralser M. Olin-Sandoval V, et al. Nature. 2019 Aug;572(7768):249-253. doi: 10.1038/s41586-019-1442-6. Epub 2019 Jul 31. Nature. 2019. PMID: 31367038 Free PMC article.