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Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression.
Bonner SM, Pietropaolo SL, Fan Y, Chang Y, Sethupathy P, Morran MP, Beems M, Giannoukakis N, Trucco G, Palumbo MO, Solimena M, Pugliese A, Polychronakos C, Trucco M, Pietropaolo M. Bonner SM, et al. J Biol Chem. 2012 May 18;287(21):17882-17893. doi: 10.1074/jbc.M111.319020. Epub 2012 Mar 24. J Biol Chem. 2012. PMID: 22447927 Free PMC article.
Compromised central tolerance of ICA69 induces multiple organ autoimmunity.
Fan Y, Gualtierotti G, Tajima A, Grupillo M, Coppola A, He J, Bertera S, Owens G, Pietropaolo M, Rudert WA, Trucco M. Fan Y, et al. J Autoimmun. 2014 Sep;53:10-25. doi: 10.1016/j.jaut.2014.07.001. Epub 2014 Aug 1. J Autoimmun. 2014. PMID: 25088457 Free PMC article.
Primer: immunity and autoimmunity.
Pietropaolo M, Surhigh JM, Nelson PW, Eisenbarth GS. Pietropaolo M, et al. Diabetes. 2008 Nov;57(11):2872-82. doi: 10.2337/db07-1691. Diabetes. 2008. PMID: 18971434 Free PMC article. No abstract available.
Immunogenetics of type 1 diabetes mellitus.
Morran MP, Vonberg A, Khadra A, Pietropaolo M. Morran MP, et al. Mol Aspects Med. 2015 Apr;42:42-60. doi: 10.1016/j.mam.2014.12.004. Epub 2015 Jan 8. Mol Aspects Med. 2015. PMID: 25579746 Free PMC article. Review.
14 results