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Page 1
Effects of 23-epi-26-deoxyactein on adipogenesis in 3T3-L1 preadipocytes and diet-induced obesity in C57BL/6 mice.
Yuan J, Shi Q, Chen J, Lu J, Wang L, Qiu M, Liu J. Yuan J, et al. Phytomedicine. 2020 Jun 5;76:153264. doi: 10.1016/j.phymed.2020.153264. Online ahead of print. Phytomedicine. 2020. PMID: 32570112 Free article.
However, it remains unclear which A. racemosa components are responsible for these beneficial effects. PURPOSE: We aimed to examine the anti-obesity potential of 23-epi-26-deoxyactein (DA), which is contained in the ethanolic extracts of A. racemosa. . …
However, it remains unclear which A. racemosa components are responsible for these beneficial effects. PURPOSE: We aimed to examine the anti …
Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh.
van Breemen RB, Liang W, Banuvar S, Shulman LP, Pang Y, Tao Y, Nikolic D, Krock KM, Fabricant DS, Chen SN, Hedayat S, Bolton JL, Pauli GF, Piersen CE, Krause EC, Geller SE, Farnsworth NR. van Breemen RB, et al. Clin Pharmacol Ther. 2010 Feb;87(2):219-25. doi: 10.1038/clpt.2009.251. Epub 2009 Dec 23. Clin Pharmacol Ther. 2010. PMID: 20032972 Free PMC article. Clinical Trial.
This study investigates the maximum tolerated dose of a 75% ethanol extract of black cohosh and determines the pharmacokinetics of one of its most abundant triterpene glycosides, 23-epi-26-deoxyactein. Single doses of black cohosh extract containing 1. …
This study investigates the maximum tolerated dose of a 75% ethanol extract of black cohosh and determines the pharmacokinetics of one of it …
LC/TIS-MS fingerprint profiling of Cimicifuga species and analysis of 23-Epi-26-deoxyactein in Cimicifuga racemosa commercial products.
Wang HK, Sakurai N, Shih CY, Lee KH. Wang HK, et al. J Agric Food Chem. 2005 Mar 9;53(5):1379-86. doi: 10.1021/jf048300d. J Agric Food Chem. 2005. PMID: 15740010
A highly selective and sensitive LC/MS/MS method for quantitative analysis of 23-epi-26-deoxyactein with detection levels up to 2.5 ng in these samples was also developed and was applied to six commercial C. racemosa products. C. racemosa and its six c …
A highly selective and sensitive LC/MS/MS method for quantitative analysis of 23-epi-26-deoxyactein with detecti …
Simultaneous determination of cimicifugoside H-2, cimicifugoside H-1, 23-epi-26-deoxyactein, cimigenol xyloside and 25-O-acetylcimigenoside in beagle dog plasma by LC-MS/MS.
Wang Y, Sha C, Liu W, Gai Y, Zhang H, Qu H, Wang W. Wang Y, et al. J Pharm Biomed Anal. 2012 Mar 25;62:87-95. doi: 10.1016/j.jpba.2011.11.029. Epub 2011 Dec 9. J Pharm Biomed Anal. 2012. PMID: 22285707
The average extraction recoveries were 73-74% for cimicifugoside H-2, 89-94% for cimicifugoside H-1, 73-80% for 23-epi-26-deoxyactein, 89-91% for cimigenol xyloside, 87-96% for 25-O-acetylcimigenoside, respectively. ...This method was successfully appl …
The average extraction recoveries were 73-74% for cimicifugoside H-2, 89-94% for cimicifugoside H-1, 73-80% for 23-epi-26
Isolation, structure elucidation, and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein.
Chen SN, Li W, Fabricant DS, Santarsiero BD, Mesecar A, Fitzloff JF, Fong HH, Farnsworth NR. Chen SN, et al. J Nat Prod. 2002 Apr;65(4):601-5. doi: 10.1021/np010494t. J Nat Prod. 2002. PMID: 11975513
A new triterpene glycoside, 26-deoxyactein (1), along with two known compounds, 23-epi-26-deoxyactein (2), previously designated as "27-deoxyactein", and actein (3), were isolated from the roots/rhizomes of Cimicifuga racemosa. ...
A new triterpene glycoside, 26-deoxyactein (1), along with two known compounds, 23-epi-26-deoxyactein
In Vitro and In Situ Characterization of Triterpene Glycosides From Cimicifuga racemosa Extract.
Disch L, Forsch K, Siewert B, Drewe J, Fricker G. Disch L, et al. J Pharm Sci. 2017 Dec;106(12):3642-3650. doi: 10.1016/j.xphs.2017.07.023. Epub 2017 Aug 4. J Pharm Sci. 2017. PMID: 28827038
Over a physiological pH range, triterpene glycosides exhibited pH-dependent solubility with highest concentration at pH 7.5. Dissolution profiles showed rapid dissolution of actein and 23-epi-26-deoxyactein. Furthermore, 23-epi-26- …
Over a physiological pH range, triterpene glycosides exhibited pH-dependent solubility with highest concentration at pH 7.5. Dissolution pro …
27-Deoxyactein prevents 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cellular damage in MC3T3-E1 osteoblastic cells.
Suh KS, Choi EM, Jung WW, Park SY, Chin SO, Rhee SY, Pak YK, Chon S. Suh KS, et al. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2018 May 12;53(6):561-570. doi: 10.1080/10934529.2018.1428275. Epub 2018 Jan 24. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2018. PMID: 29364047
Additionally, TCDD-induced increases in the levels of aryl hydrocarbon receptor (AhR), cytochrome P450 1A1 (CYP1A1), and extracellular signal-regulated kinase (ERK) were significantly inhibited by 27-deoxyactein. The mRNA levels of superoxide dismutase (SOD), ERK1, and nuc …
Additionally, TCDD-induced increases in the levels of aryl hydrocarbon receptor (AhR), cytochrome P450 1A1 (CYP1A1), and extracellular signa …
Deoxyactein Isolated from Cimicifuga racemosa protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity.
Choi EM. Choi EM. J Appl Toxicol. 2013 Jun;33(6):488-94. doi: 10.1002/jat.1784. Epub 2011 Dec 19. J Appl Toxicol. 2013. PMID: 22180388
Deoxyactein is one of the major constituents isolated from Cimicifuga racemosa. ...All these data indicate that deoxyactein may reduce or prevent osteoblasts degeneration in osteoporosis or other degenerative disorders....
Deoxyactein is one of the major constituents isolated from Cimicifuga racemosa. ...All these data indicate that deoxyactein ma
Cyclolanostane triterpene glycosides from Souliea vaginata.
Zhou L, Yang JS, Tu GZ, Zou JH. Zhou L, et al. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):823-6. doi: 10.1248/cpb.54.823. Chem Pharm Bull (Tokyo). 2006. PMID: 16755051 Free article.
Five new cyclolanostane triterpene glycosides, 12-deacetyloxy-15alpha-hydroxy-23-epi-26-deoxyactein, 12-deacetyloxy-23-epi-26-deoxyactein, 24-O-acetyldahurinol-3-O-beta-D-xylopyranoside, 12beta-hydroxycimigenol-3-O-beta-D-xy …
Five new cyclolanostane triterpene glycosides, 12-deacetyloxy-15alpha-hydroxy-23-epi-26-deoxyactein, 12-deacetyl …
Deoxyactein stimulates osteoblast function and inhibits bone-resorbing mediators in MC3T3-E1 cells.
Choi EM. Choi EM. J Appl Toxicol. 2013 Mar;33(3):190-5. doi: 10.1002/jat.1733. Epub 2011 Sep 9. J Appl Toxicol. 2013. PMID: 21910134
In the present study, the effect of deoxyactein on the function of osteoblastic MC3T3-E1 cells was studied. ...These results demonstrate that deoxyactein may have positive effects on skeletal structure....
In the present study, the effect of deoxyactein on the function of osteoblastic MC3T3-E1 cells was studied. ...These results demonstr …
27 results