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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2009 9
2010 12
2011 19
2012 14
2013 12
2014 1
2020 0
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62 results
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Page 1
Mitonuclear protein imbalance as a conserved longevity mechanism.
Houtkooper RH, Mouchiroud L, Ryu D, Moullan N, Katsyuba E, Knott G, Williams RW, Auwerx J. Houtkooper RH, et al. Nature. 2013 May 23;497(7450):451-7. doi: 10.1038/nature12188. Nature. 2013. PMID: 23698443 Free PMC article.
Sirtuins as regulators of metabolism and healthspan.
Houtkooper RH, Pirinen E, Auwerx J. Houtkooper RH, et al. Nat Rev Mol Cell Biol. 2012 Mar 7;13(4):225-238. doi: 10.1038/nrm3293. Nat Rev Mol Cell Biol. 2012. PMID: 22395773 Free PMC article. Review.
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.
Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Cantó C, Mottis A, Jo YS, Viswanathan M, Schoonjans K, Guarente L, Auwerx J. Mouchiroud L, et al. Cell. 2013 Jul 18;154(2):430-41. doi: 10.1016/j.cell.2013.06.016. Cell. 2013. PMID: 23870130 Free PMC article.
The metabolic footprint of aging in mice.
Houtkooper RH, Argmann C, Houten SM, Cantó C, Jeninga EH, Andreux PA, Thomas C, Doenlen R, Schoonjans K, Auwerx J. Houtkooper RH, et al. Sci Rep. 2011;1:134. doi: 10.1038/srep00134. Epub 2011 Oct 31. Sci Rep. 2011. PMID: 22355651 Free PMC article.
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.
Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J. Cantó C, et al. Cell Metab. 2012 Jun 6;15(6):838-47. doi: 10.1016/j.cmet.2012.04.022. Cell Metab. 2012. PMID: 22682224 Free PMC article.
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.
Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J. Cantó C, et al. Nature. 2009 Apr 23;458(7241):1056-60. doi: 10.1038/nature07813. Nature. 2009. PMID: 19262508 Free PMC article.
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.
Bai P, Cantó C, Oudart H, Brunyánszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper RH, Schoonjans K, Schreiber V, Sauve AA, Menissier-de Murcia J, Auwerx J. Bai P, et al. Cell Metab. 2011 Apr 6;13(4):461-468. doi: 10.1016/j.cmet.2011.03.004. Cell Metab. 2011. PMID: 21459330 Free PMC article.
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, Kim J, Woo J, Kim JH, Choi BH, He B, Chen W, Zhang S, Cerione RA, Auwerx J, Hao Q, Lin H. Du J, et al. Science. 2011 Nov 11;334(6057):806-9. doi: 10.1126/science.1207861. Science. 2011. PMID: 22076378 Free PMC article.
TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading.
Pols TW, Nomura M, Harach T, Lo Sasso G, Oosterveer MH, Thomas C, Rizzo G, Gioiello A, Adorini L, Pellicciari R, Auwerx J, Schoonjans K. Pols TW, et al. Cell Metab. 2011 Dec 7;14(6):747-57. doi: 10.1016/j.cmet.2011.11.006. Cell Metab. 2011. PMID: 22152303 Free PMC article.
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