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The substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition.
Biochemistry. 2013 Mar 12;52(10):1776-87. doi: 10.1021/bi301387m. Epub 2013 Feb 28.
Biochemistry. 2013.
PMID: 23363292
The crystal structure of TrpD, a metabolic enzyme essential for lung colonization by Mycobacterium tuberculosis, in complex with its substrate phosphoribosylpyrophosphate.
Lee CE, Goodfellow C, Javid-Majd F, Baker EN, Shaun Lott J.
Lee CE, et al.
J Mol Biol. 2006 Jan 27;355(4):784-97. doi: 10.1016/j.jmb.2005.11.016. Epub 2005 Nov 22.
J Mol Biol. 2006.
PMID: 16337227
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