ZNF804A and cortical thickness in schizophrenia and bipolar disorder

Orjan Bergmann; Unn K Haukvik; Andrew A Brown; Lars M Rimol; Cecilie B Hartberg; Lavinia Athanasiu; Ingrid Melle; Srdjan Djurovic; Ole A Andreassen; Anders M Dale; Ingrid Agartz

doi:10.1016/j.pscychresns.2013.01.007

ZNF804A and cortical thickness in schizophrenia and bipolar disorder

Psychiatry Res. 2013 May 30;212(2):154-7. doi: 10.1016/j.pscychresns.2013.01.007. Epub 2013 Apr 4.

Authors

Orjan Bergmann¹, Unn K Haukvik, Andrew A Brown, Lars M Rimol, Cecilie B Hartberg, Lavinia Athanasiu, Ingrid Melle, Srdjan Djurovic, Ole A Andreassen, Anders M Dale, Ingrid Agartz

Affiliation

¹ KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. orjan.bergmann@medisin.uio.no

PMID: 23562677
DOI: 10.1016/j.pscychresns.2013.01.007

Abstract

ZNF804A SNP rs1344706 confers genome-wide risk for schizophrenia and bipolar disorder. Both disorders affect cortical thickness. To determine if single nucleotide polymorphisms (SNPs) across ZNF804A are associated with cortical thinning, we investigated 63 SNPs (including rs1344706) in 365 psychosis patients and healthy controls. Results show no significant associations.

MeSH terms

Adult
Bipolar Disorder / genetics*
Bipolar Disorder / pathology
Cerebral Cortex / pathology*
Female
Gene Frequency
Genetic Predisposition to Disease*
Genome-Wide Association Study
Genotype
Humans
Image Processing, Computer-Assisted
Kruppel-Like Transcription Factors / genetics*
Magnetic Resonance Imaging
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Schizophrenia / genetics*
Schizophrenia / pathology
Young Adult

Substances

Kruppel-Like Transcription Factors
ZNF804A protein, human