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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 2
1975 9
1976 5
1977 5
1978 12
1979 15
1980 16
1981 21
1982 23
1983 27
1984 26
1985 36
1986 29
1987 45
1988 24
1989 47
1990 29
1991 36
1992 39
1993 34
1994 29
1995 50
1996 39
1997 38
1998 43
1999 41
2000 32
2001 37
2002 28
2003 30
2004 30
2005 23
2006 37
2007 28
2008 23
2009 41
2010 30
2011 22
2012 33
2013 34
2014 45
2015 34
2016 31
2017 45
2018 41
2019 57
2020 47
2021 50
2022 51
2023 51
2024 47
2025 67
2026 44

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1,659 results

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Page 1
25-Hydroxycholesterol in health and diseases.
Nguyen C, Saint-Pol J, Dib S, Pot C, Gosselet F. Nguyen C, et al. J Lipid Res. 2024 Jan;65(1):100486. doi: 10.1016/j.jlr.2023.100486. Epub 2023 Dec 16. J Lipid Res. 2024. PMID: 38104944 Free PMC article. Review.
Among all the existing oxysterols, this review summarizes basic as well as recent knowledge on 25-hydroxycholesterol which is mainly produced during inflammatory or infectious situations and that in turn contributes to immune response, central nervous system disorde …
Among all the existing oxysterols, this review summarizes basic as well as recent knowledge on 25-hydroxycholesterol which is …
25-Hydroxycholesterol as a Signaling Molecule of the Nervous System.
Odnoshivkina UG, Kuznetsova EA, Petrov AM. Odnoshivkina UG, et al. Biochemistry (Mosc). 2022 Jun;87(6):524-537. doi: 10.1134/S0006297922060049. Biochemistry (Mosc). 2022. PMID: 35790411 Free PMC article. Review.
HCs regulate cellular homeostasis of cholesterol; they can pass across the membrane and vascular barriers and act distantly as para- and endocrine agents. A small amount of 25-hydroxycholesterol (25-HC) is produced in the endoplasmic reticulum of most cells, …
HCs regulate cellular homeostasis of cholesterol; they can pass across the membrane and vascular barriers and act distantly as para- and end …
25-hydroxycholesterol: an integrator of antiviral ability and signaling.
Zhang J, Zhu Y, Wang X, Wang J. Zhang J, et al. Front Immunol. 2023 Sep 13;14:1268104. doi: 10.3389/fimmu.2023.1268104. eCollection 2023. Front Immunol. 2023. PMID: 37781400 Free PMC article. Review.
Oxysterols especially hydroxylated cholesterols are recognized as novel regulators of the innate immune response. The antiviral ability of 25HC (25-Hydroxycholesterol) is uncovered due to its role as a metabolic product of the interferon-stimulated gene CH25H (chole …
Oxysterols especially hydroxylated cholesterols are recognized as novel regulators of the innate immune response. The antiviral ability of 2 …
25-Hydroxycholesterol modulates microglial function and exacerbates Alzheimer's disease pathology: mechanistic insights and therapeutic potential of cholesterol esterification inhibition.
Choi H, Kim HJ, Lee SE, Song HH, Kim J, Han J, Jeong JH, Lee DY, Chang S, Mook-Jung I. Choi H, et al. J Neuroinflammation. 2025 Feb 25;22(1):50. doi: 10.1186/s12974-025-03357-y. J Neuroinflammation. 2025. PMID: 40001197 Free PMC article.
This study investigates the role of 25-hydroxycholesterol (25HC), a metabolite produced by cholesterol hydroxylase encoded by the Ch25h gene, in modulating microglial function and its potential implications in Alzheimer's disease (AD) pathology. ...
This study investigates the role of 25-hydroxycholesterol (25HC), a metabolite produced by cholesterol hydroxylase encoded by …
Pathogenic role of 25-hydroxycholesterol in cancer development and progression.
Ejam SS, Saleh RO, Catalan Opulencia MJ, Najm MA, Makhmudova A, Jalil AT, Abdelbasset WK, Al-Gazally ME, Hammid AT, Mustafa YF, Sergeevna SE, Karampoor S, Mirzaei R. Ejam SS, et al. Future Oncol. 2022 Dec;18(39):4415-4442. doi: 10.2217/fon-2022-0819. Epub 2023 Jan 18. Future Oncol. 2022. PMID: 36651359 Review.
Cholesterol is an essential lipid that serves several important functions, including maintaining the homeostasis of cells, acting as a precursor to bile acid and steroid hormones and preserving the stability of membrane lipid rafts. 25-hydroxycholesterol (25- …
Cholesterol is an essential lipid that serves several important functions, including maintaining the homeostasis of cells, acting as a precu …
25-hydroxycholesterol promotes brain cytokine production and leukocyte infiltration in a mouse model of lipopolysaccharide-induced neuroinflammation.
Romero J, Toral-Rios D, Yu J, Paul SM, Cashikar AG. Romero J, et al. J Neuroinflammation. 2024 Oct 5;21(1):251. doi: 10.1186/s12974-024-03233-1. J Neuroinflammation. 2024. PMID: 39369253 Free PMC article.
Ch25h encodes cholesterol 25-hydroxylase, an enzyme upregulated in activated microglia under conditions of neuroinflammation, that hydroxylates cholesterol to form 25-hydroxycholesterol (25HC). 25HC can be further metabolized to 7alpha,25-dihydroxycholesterol, which …
Ch25h encodes cholesterol 25-hydroxylase, an enzyme upregulated in activated microglia under conditions of neuroinflammation, that hydroxyla …
25-hydroxycholesterol: Gatekeeper of intestinal IgA.
Piper CJM, Mauri C. Piper CJM, et al. Immunity. 2021 Oct 12;54(10):2182-2185. doi: 10.1016/j.immuni.2021.09.017. Immunity. 2021. PMID: 34644552 Free article.
In this issue of Immunity, Trindade et al. (2021) report how the cholesterol metabolite 25-hydroxycholesterol restrains IgA plasma cell differentiation from germinal-center B cells in the Peyer's patches through regulation of the sterol-sensing transcription factor …
In this issue of Immunity, Trindade et al. (2021) report how the cholesterol metabolite 25-hydroxycholesterol restrains IgA pl …
25-hydroxycholesterol triggers antioxidant signaling in mouse atria.
Odnoshivkina JG, Petrov AM. Odnoshivkina JG, et al. Prostaglandins Other Lipid Mediat. 2024 Jun;172:106834. doi: 10.1016/j.prostaglandins.2024.106834. Epub 2024 Mar 21. Prostaglandins Other Lipid Mediat. 2024. PMID: 38521490
Oxysterol, 25-hydroxycholesterol (25HC), is a potent regulator of immune reactions, its synthesis greatly increases by macrophages during inflammation. ...
Oxysterol, 25-hydroxycholesterol (25HC), is a potent regulator of immune reactions, its synthesis greatly increases by macroph …
25-Hydroxycholesterol inhibits Hantavirus infection by reprogramming cholesterol metabolism.
Dang Y, Wang Y, Wei J, Zhang H, Yang Q, Wang B, Li J, Ye C, Chen Y, Han P, Jin X, Wang J, Bao X, Liu H, Ma H, Zhang L, Cheng L, Dong Y, Bai Y, Li Y, Lei Y, Xu Z, Zhang F, Ye W. Dang Y, et al. Free Radic Biol Med. 2024 Nov 1;224:232-245. doi: 10.1016/j.freeradbiomed.2024.08.029. Epub 2024 Aug 28. Free Radic Biol Med. 2024. PMID: 39209137
A product of ISGs, the enzyme cholesterol 25-hydroxylase (CH25H), catalyzes the oxidation of cholesterol to 25-hydroxycholesterol (25HC). 25HC can inhibit multiple enveloped-virus infections, but the mechanism is largely unknown, and whether 25HC plays an important …
A product of ISGs, the enzyme cholesterol 25-hydroxylase (CH25H), catalyzes the oxidation of cholesterol to 25-hydroxycholesterol …
1,659 results