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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 2
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1981 21
1982 23
1983 27
1984 26
1985 36
1986 29
1987 45
1988 24
1989 47
1990 29
1991 36
1992 39
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1994 29
1995 50
1996 39
1997 38
1998 43
1999 41
2000 32
2001 37
2002 28
2003 30
2004 30
2005 23
2006 37
2007 28
2008 23
2009 41
2010 30
2011 22
2012 33
2013 34
2014 45
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2017 45
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2019 57
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1,575 results

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Page 1
25-Hydroxycholesterol as a Signaling Molecule of the Nervous System.
Odnoshivkina UG, Kuznetsova EA, Petrov AM. Odnoshivkina UG, et al. Biochemistry (Mosc). 2022 Jun;87(6):524-537. doi: 10.1134/S0006297922060049. Biochemistry (Mosc). 2022. PMID: 35790411 Free PMC article. Review.
HCs regulate cellular homeostasis of cholesterol; they can pass across the membrane and vascular barriers and act distantly as para- and endocrine agents. A small amount of 25-hydroxycholesterol (25-HC) is produced in the endoplasmic reticulum of most cells, where i …
HCs regulate cellular homeostasis of cholesterol; they can pass across the membrane and vascular barriers and act distantly as para- and end …
25-Hydroxycholesterol in health and diseases.
Nguyen C, Saint-Pol J, Dib S, Pot C, Gosselet F. Nguyen C, et al. J Lipid Res. 2024 Jan;65(1):100486. doi: 10.1016/j.jlr.2023.100486. Epub 2023 Dec 16. J Lipid Res. 2024. PMID: 38104944 Free PMC article. Review.
Among all the existing oxysterols, this review summarizes basic as well as recent knowledge on 25-hydroxycholesterol which is mainly produced during inflammatory or infectious situations and that in turn contributes to immune response, central nervous system disorde …
Among all the existing oxysterols, this review summarizes basic as well as recent knowledge on 25-hydroxycholesterol which is …
25-hydroxycholesterol: an integrator of antiviral ability and signaling.
Zhang J, Zhu Y, Wang X, Wang J. Zhang J, et al. Front Immunol. 2023 Sep 13;14:1268104. doi: 10.3389/fimmu.2023.1268104. eCollection 2023. Front Immunol. 2023. PMID: 37781400 Free PMC article. Review.
Oxysterols especially hydroxylated cholesterols are recognized as novel regulators of the innate immune response. The antiviral ability of 25HC (25-Hydroxycholesterol) is uncovered due to its role as a metabolic product of the interferon-stimulated gene CH25H (chole …
Oxysterols especially hydroxylated cholesterols are recognized as novel regulators of the innate immune response. The antiviral ability of 2 …
The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation.
Trindade BC, Ceglia S, Berthelette A, Raso F, Howley K, Muppidi JR, Reboldi A. Trindade BC, et al. Immunity. 2021 Oct 12;54(10):2273-2287.e6. doi: 10.1016/j.immuni.2021.09.004. Immunity. 2021. PMID: 34644558 Free PMC article.
Here, we examined how the cholesterol metabolite 25-hydroxycholesterol (25-HC) impacts the intestinal B cell response. Mice lacking cholesterol 25-hydroxylase (CH25H), the enzyme generating 25-HC, had higher frequencies of immunoglobulin A (IgA)-secreting antigen-sp …
Here, we examined how the cholesterol metabolite 25-hydroxycholesterol (25-HC) impacts the intestinal B cell response. Mice la …
Pathogenic role of 25-hydroxycholesterol in cancer development and progression.
Ejam SS, Saleh RO, Catalan Opulencia MJ, Najm MA, Makhmudova A, Jalil AT, Abdelbasset WK, Al-Gazally ME, Hammid AT, Mustafa YF, Sergeevna SE, Karampoor S, Mirzaei R. Ejam SS, et al. Future Oncol. 2022 Dec;18(39):4415-4442. doi: 10.2217/fon-2022-0819. Epub 2023 Jan 18. Future Oncol. 2022. PMID: 36651359 Review.
Cholesterol is an essential lipid that serves several important functions, including maintaining the homeostasis of cells, acting as a precursor to bile acid and steroid hormones and preserving the stability of membrane lipid rafts. 25-hydroxycholesterol (25-HC) is …
Cholesterol is an essential lipid that serves several important functions, including maintaining the homeostasis of cells, acting as a precu …
25-Hydroxycholesterol exacerbates vascular leak during acute lung injury.
Madenspacher JH, Morrell ED, McDonald JG, Thompson BM, Li Y, Birukov KG, Birukova AA, Stapleton RD, Alejo A, Karmaus PW, Meacham JM, Rai P, Mikacenic C, Wurfel MM, Fessler MB. Madenspacher JH, et al. JCI Insight. 2023 Apr 10;8(7):e155448. doi: 10.1172/jci.insight.155448. JCI Insight. 2023. PMID: 36821369 Free PMC article.
Cholesterol-25-hydroxylase (CH25H), the biosynthetic enzyme for 25-hydroxycholesterol (25HC), is most highly expressed in the lung, but its role in lung biology is poorly defined. ...
Cholesterol-25-hydroxylase (CH25H), the biosynthetic enzyme for 25-hydroxycholesterol (25HC), is most highly expressed in the …
Regulation of astrocyte lipid metabolism and ApoE secretionby the microglial oxysterol, 25-hydroxycholesterol.
Cashikar AG, Toral-Rios D, Timm D, Romero J, Strickland M, Long JM, Han X, Holtzman DM, Paul SM. Cashikar AG, et al. J Lipid Res. 2023 Apr;64(4):100350. doi: 10.1016/j.jlr.2023.100350. Epub 2023 Feb 25. J Lipid Res. 2023. PMID: 36849076 Free PMC article.
Relative to homeostatic microglia, activated microglia express higher levels of Ch25h, an enzyme that hydroxylates cholesterol to produce 25-hydroxycholesterol (25HC). 25HC is an oxysterol with interesting immune roles stemming from its ability to regulate cholester …
Relative to homeostatic microglia, activated microglia express higher levels of Ch25h, an enzyme that hydroxylates cholesterol to produce …
25-hydroxycholesterol: Gatekeeper of intestinal IgA.
Piper CJM, Mauri C. Piper CJM, et al. Immunity. 2021 Oct 12;54(10):2182-2185. doi: 10.1016/j.immuni.2021.09.017. Immunity. 2021. PMID: 34644552 Free article.
In this issue of Immunity, Trindade et al. (2021) report how the cholesterol metabolite 25-hydroxycholesterol restrains IgA plasma cell differentiation from germinal-center B cells in the Peyer's patches through regulation of the sterol-sensing transcription factor …
In this issue of Immunity, Trindade et al. (2021) report how the cholesterol metabolite 25-hydroxycholesterol restrains IgA pl …
25-Hydroxycholesterol Effect on Membrane Structure and Mechanical Properties.
Domingues MM, Gomes B, Hollmann A, Santos NC. Domingues MM, et al. Int J Mol Sci. 2021 Mar 4;22(5):2574. doi: 10.3390/ijms22052574. Int J Mol Sci. 2021. PMID: 33806504 Free PMC article.
Cholesterol homeostasis is regulated by oxysterols, such as 25-hydroxycholesterol. The presence of 25-hydroxycholesterol at the membrane level has been shown to interfere with several viruses' entry into their target cells. ...This study indicates that …
Cholesterol homeostasis is regulated by oxysterols, such as 25-hydroxycholesterol. The presence of 25-hydroxycholest …
1,575 results