Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2010 1
2011 1
2016 1
2017 5
2018 1
2019 1
2020 2
2021 3
2022 1
2023 1
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

14 results

Results by year

Filters applied: . Clear all
The following term was not found in PubMed: NBOH-2CI
Page 1
2-((2-(4-Iodo-2,5-dimethoxyphenyl)ethylamino)methyl)phenol (25I-NBOH) and 2-(((2-(4-chloro-2,5-dimethoxyphenyl)ethyl)amino)methyl)phenol (25C-NBOH) induce adverse effects on the cardiovascular system.
Yoon KS, Cha HJ, Choi SO, Lee JM. Yoon KS, et al. Toxicol Lett. 2022 Feb 1;355:160-169. doi: 10.1016/j.toxlet.2021.11.016. Epub 2021 Nov 26. Toxicol Lett. 2022. PMID: 34843874
Meanwhile, these two compounds significantly increased QT intervals and RR intervals in the rat ECG measurement. 25I-NBOH down-regulated the PAK1 protein expression in rat primary cardiomyocytes as well as H9c2 cells. ...Taken together, these results suggest that bo …
Meanwhile, these two compounds significantly increased QT intervals and RR intervals in the rat ECG measurement. 25I-NBOH down …
Characterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH.
Nielsen LM, Holm NB, Leth-Petersen S, Kristensen JL, Olsen L, Linnet K. Nielsen LM, et al. Drug Test Anal. 2017 May;9(5):671-679. doi: 10.1002/dta.2031. Epub 2016 Jul 12. Drug Test Anal. 2017. PMID: 27400739
The study was further substantiated by an evaluation of 25I-NBOMe and 25I-NBOH metabolism in single donor HLM. The metabolism pathways of 25I-NBOMe and 25I-NBOH were NADPHdependent with intrinsic clearance values of (CLint) of 70.1 and 118.7 mL/min/kg, …
The study was further substantiated by an evaluation of 25I-NBOMe and 25I-NBOH metabolism in single donor HLM. The metabolism …
Neurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: High potency agonists at 5-HT2A receptors.
Eshleman AJ, Wolfrum KM, Reed JF, Kim SO, Johnson RA, Janowsky A. Eshleman AJ, et al. Biochem Pharmacol. 2018 Dec;158:27-34. doi: 10.1016/j.bcp.2018.09.024. Epub 2018 Sep 25. Biochem Pharmacol. 2018. PMID: 30261175 Free PMC article.
The substituted phenethylamines were very low potency and low efficacy agonists at the 5-HT(1A) receptor. 25D-NBOMe, 25E-NBOMe, 25H-NBOMe, 25I-NBOH and 25N-NBOMe had very high affinity for, and full efficacy at, 5-HT(2A) and 5-HT(2C) receptors. In the 5-HT(2A) recep …
The substituted phenethylamines were very low potency and low efficacy agonists at the 5-HT(1A) receptor. 25D-NBOMe, 25E-NBOMe, 25H-NBOMe, …
25I-NBOH: a new potent serotonin 5-HT(2A) receptor agonist identified in blotter paper seizures in Brazil.
Arantes LC, Júnior EF, de Souza LF, Cardoso AC, Alcântara TLF, Lião LM, Machado Y, Lordeiro RA, Neto JC, Andrade AFB. Arantes LC, et al. Forensic Toxicol. 2017;35(2):408-414. doi: 10.1007/s11419-017-0357-x. Epub 2017 Feb 16. Forensic Toxicol. 2017. PMID: 28706567 Free PMC article.
Individual doses range from 300 to 1000 mug. Despite its being a potent 5-HT(2A) receptor agonist, 25I-NBOH is neither registered in the United Nations Office on Drugs and Crime (UNODC) nor classified as a scheduled substance in most countries. Sweden and Brazil see …
Individual doses range from 300 to 1000 mug. Despite its being a potent 5-HT(2A) receptor agonist, 25I-NBOH is neither registe …
Electroanalytical identification of 25I-NBOH and 2C-I via differential pulse voltammetry: a rapid and sensitive screening method to avoid misidentification.
Belchior de Andrade AF, Gonzalez-Rodriguez J. Belchior de Andrade AF, et al. Analyst. 2019 May 7;144(9):2965-2972. doi: 10.1039/c9an00062c. Epub 2019 Mar 6. Analyst. 2019. PMID: 30839986
25I-NBOH is a new potent serotonin 5-HT2A receptor agonist recently identified in blotter paper seizures. ...This method is selective and achieves full differentiation between 25I-NBOH, 2C-I and 25I-NBOMe....
25I-NBOH is a new potent serotonin 5-HT2A receptor agonist recently identified in blotter paper seizures. ...This method is se
Challenges in the identification of new thermolabile psychoactive substances: The 25I-NBOH case.
Belchior de Andrade AF, Elie M, Weck C, Jardim Zacca J, de Souza MP, Caldas LNB, Gonzalez-Rodriguez J. Belchior de Andrade AF, et al. Forensic Sci Int. 2020 Jul;312:110306. doi: 10.1016/j.forsciint.2020.110306. Epub 2020 Apr 27. Forensic Sci Int. 2020. PMID: 32408040
Also, a series of method adjustments is displayed, encompassing variation on the injector temperature, split ratio and flow ratio, although with no success to prevent 25I-NBOH thermo degradation in the GC injector. Furthermore, differential scanning calorimetry and …
Also, a series of method adjustments is displayed, encompassing variation on the injector temperature, split ratio and flow ratio, although …
Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT (2A) agonist PET tracers.
Ettrup A, Hansen M, Santini MA, Paine J, Gillings N, Palner M, Lehel S, Herth MM, Madsen J, Kristensen J, Begtrup M, Knudsen GM. Ettrup A, et al. Eur J Nucl Med Mol Imaging. 2011 Apr;38(4):681-93. doi: 10.1007/s00259-010-1686-8. Epub 2010 Dec 21. Eur J Nucl Med Mol Imaging. 2011. PMID: 21174090
The cortical binding of [(11)C]Cimbi-36 was decreased by pretreatment with ketanserin, supporting 5-HT(2A) receptor selectivity in vivo. [(11)C]Cimbi-82 and [(11)C]Cimbi-21 showed lower cortical BP(ND), while [(11)C]Cimbi-27, [(11)C]Cimbi-29, [(11)C]Cimbi-31 and [(1 …
The cortical binding of [(11)C]Cimbi-36 was decreased by pretreatment with ketanserin, supporting 5-HT(2A) receptor selectivity in vivo. [(1 …
EASI-IMS an expedite and secure technique to screen for 25I-NBOH in blotter papers.
de Morais DR, Barbosa IL, Cunha KF, Tripodi GL, Angolini CFF, Franco MF, de Aquino EM, Eberlin MN, Costa JL. de Morais DR, et al. J Mass Spectrom. 2017 Oct;52(10):701-706. doi: 10.1002/jms.3977. J Mass Spectrom. 2017. PMID: 28746793
Because it usually provides secure results, gas chromatography coupled to mass spectrometry (GC-MS) has been routinely employed as the standard technique for the detection of NPS in blotter papers. For 25I-NBOH (N-(2-hydroxybenzyl)-2-( …
Because it usually provides secure results, gas chromatography coupled to mass spectrometry (GC-MS) has been routinely employed as the stand …
Severe 25E-NBOH intoxication associated with MDPHP intake: a case report, metabolism study, and literature review.
Pelletier R, Gicquel T, Carvelli J, Balaz P, Pelissier-Alicot AL, Morel I, Bottinelli C, Solas C, Le Daré B, Fabresse N. Pelletier R, et al. Int J Legal Med. 2023 Dec 20. doi: 10.1007/s00414-023-03151-6. Online ahead of print. Int J Legal Med. 2023. PMID: 38117418
We reported here the case of a 23-year-old man who presented a serotoninergic syndrome and a loss of consciousness following the consumption of a powder labelled as 25I-NBOH. Toxicological analyses of biological samples were carried out using a liquid chromatography …
We reported here the case of a 23-year-old man who presented a serotoninergic syndrome and a loss of consciousness following the consumption …
Behavioral arrest and a characteristic slow waveform are hallmark responses to selective 5-HT2A receptor activation.
Contreras A, Khumnark M, Hines RM, Hines DJ. Contreras A, et al. Sci Rep. 2021 Jan 21;11(1):1925. doi: 10.1038/s41598-021-81552-6. Sci Rep. 2021. PMID: 33479368 Free PMC article.
In response to administration of the potent and highly selective 5-HT(2A)R agonist 25I-NBOH in mice, we observe a disorganization of behavior which includes frequent episodes of behavioral arrest that consistently precede the HTR by a precise interval. ...Nicotine p …
In response to administration of the potent and highly selective 5-HT(2A)R agonist 25I-NBOH in mice, we observe a disorganizat …
14 results