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Sunitinib: Ten Years of Successful Clinical Use and Study in Advanced Renal Cell Carcinoma.

Motzer RJ, Escudier B, Gannon A, Figlin RA. Motzer RJ, et al. Oncologist. 2017 Jan;22(1):41-52. doi: 10.1634/theoncologist.2016-0197. Epub 2016 Nov 2. Oncologist. 2017. PMID: 27807302 Free PMC article.

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Tyrosine Kinase and Mammalian Target of Rapamycin Inhibitors in the Treatment of Advanced Renal Cell Carcinoma: Practical Clinical Implications of Pharmacologic Features.

Parikh RA, Appleman LJ, Beumer JH, Matczak E, Chu E. Parikh RA, et al. Clin Genitourin Cancer. 2017 Feb;15(1):7-22. doi: 10.1016/j.clgc.2016.05.011. Epub 2016 May 31. Clin Genitourin Cancer. 2017. PMID: 27473523 Review.

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A Phase I Trial of the MET/ALK/ROS1 Inhibitor Crizotinib Combined with the VEGF Inhibitor Pazopanib in Patients with Advanced Solid Malignancies.

Piha-Paul SA, Dumbrava EE, Nair BC, Xiong W, Xu L, Mostorino R, Subbiah V, Tannir N, Fu S, Naing A, Janku F, Karp DD, Patel S, Daw NC, Hong D, Meric-Bernstam F, Zinner R. Piha-Paul SA, et al. Onco Targets Ther. 2021 May 7;14:3037-3049. doi: 10.2147/OTT.S291801. eCollection 2021. Onco Targets Ther. 2021. PMID: 33994796 Free PMC article. Clinical Trial.

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Identification of Key Genes and Pathways in Osteosarcoma by Bioinformatics Analysis.

Chen X, Zhang N, Zheng Y, Tong Z, Yang T, Kang X, He Y, Dong L. Chen X, et al. Comput Math Methods Med. 2022 Jan 15;2022:7549894. doi: 10.1155/2022/7549894. eCollection 2022. Comput Math Methods Med. 2022. PMID: 35075370 Free PMC article.

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Population Modeling Integrating Pharmacokinetics, Pharmacodynamics, Pharmacogenetics, and Clinical Outcome in Patients With Sunitinib-Treated Cancer.

Diekstra MH, Fritsch A, Kanefendt F, Swen JJ, Moes D, Sörgel F, Kinzig M, Stelzer C, Schindele D, Gauler T, Hauser S, Houtsma D, Roessler M, Moritz B, Mross K, Bergmann L, Oosterwijk E, Kiemeney LA, Guchelaar HJ, Jaehde U. Diekstra MH, et al. CPT Pharmacometrics Syst Pharmacol. 2017 Sep;6(9):604-613. doi: 10.1002/psp4.12210. Epub 2017 Jul 13. CPT Pharmacometrics Syst Pharmacol. 2017. PMID: 28571114 Free PMC article. Clinical Trial.

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Pazopanib: Evidence review and clinical practice in the management of advanced renal cell carcinoma.

Méndez-Vidal MJ, Molina Á, Anido U, Chirivella I, Etxaniz O, Fernández-Parra E, Guix M, Hernández C, Lambea J, Montesa Á, Pinto Á, Ros S, Gallardo E. Méndez-Vidal MJ, et al. BMC Pharmacol Toxicol. 2018 Nov 26;19(1):77. doi: 10.1186/s40360-018-0264-8. BMC Pharmacol Toxicol. 2018. PMID: 30477570 Free PMC article.

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Discovery of Dioxino[2,3-f]quinazoline derivative VEGFR-2 inhibitors exerting significant antipro-liferative activity in HUVECs and mice.

Fan H, Wei D, Zheng K, Qin X, Yang L, Yang Y, Duan Y, Xu Y, Hu L. Fan H, et al. Eur J Med Chem. 2019 Aug 1;175:349-356. doi: 10.1016/j.ejmech.2019.04.015. Epub 2019 Apr 17. Eur J Med Chem. 2019. PMID: 31096155

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Impact of CYP3A4*22 on Pazopanib Pharmacokinetics in Cancer Patients.

Bins S, Huitema ADR, Laven P, Bouazzaoui SE, Yu H, van Erp N, van Herpen C, Hamberg P, Gelderblom H, Steeghs N, Sleijfer S, van Schaik RHN, Mathijssen RHJ, Koolen SLW. Bins S, et al. Clin Pharmacokinet. 2019 May;58(5):651-658. doi: 10.1007/s40262-018-0719-5. Clin Pharmacokinet. 2019. PMID: 30367352 Free PMC article. Clinical Trial.

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Biomarkers of Prognosis and Efficacy of Anti-angiogenic Therapy in Metastatic Clear Cell Renal Cancer.

D'Aniello C, Berretta M, Cavaliere C, Rossetti S, Facchini BA, Iovane G, Mollo G, Capasso M, Pepa CD, Pesce L, D'Errico D, Buonerba C, Di Lorenzo G, Pisconti S, De Vita F, Facchini G. D'Aniello C, et al. Front Oncol. 2019 Dec 11;9:1400. doi: 10.3389/fonc.2019.01400. eCollection 2019. Front Oncol. 2019. PMID: 31921657 Free PMC article. Review.

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PharmGKB summary: pazopanib pathway, pharmacokinetics.

Thorn CF, Sharma MR, Altman RB, Klein TE. Thorn CF, et al. Pharmacogenet Genomics. 2017 Aug;27(8):307-312. doi: 10.1097/FPC.0000000000000292. Pharmacogenet Genomics. 2017. PMID: 28678138 Free PMC article. Review. No abstract available.

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