28026162 24636337 25172548 34509795 25679114 33797903 25174926 28079887 27878989 28343875 32830969 25516789 33333396 34228434 25749045 30374681 29407973 26844930 28767087 25909780 26921175 26985630 32204955 30815228 27749061 31581912 25970783 2629358 - Search Results

Year	Number of Results
2014	5
2015	8
2016	10
2017	8
2018	3
2019	5
2020	4
2021	6
2022	1
2023	1

1

hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents.

Barile E, Marconi GD, De SK, Baggio C, Gambini L, Salem AF, Kashyap MK, Castro JE, Kipps TJ, Pellecchia M. Barile E, et al. ACS Chem Biol. 2017 Feb 17;12(2):444-455. doi: 10.1021/acschembio.6b00962. Epub 2016 Dec 27. ACS Chem Biol. 2017. PMID: 28026162 Free PMC article.

2

Mcl-1 dependence predicts response to vorinostat and gemtuzumab ozogamicin in acute myeloid leukemia.

Pierceall WE, Lena RJ, Medeiros BC, Blake N, Doykan C, Elashoff M, Cardone MH, Walter RB. Pierceall WE, et al. Leuk Res. 2014 May;38(5):564-8. doi: 10.1016/j.leukres.2014.02.007. Epub 2014 Feb 28. Leuk Res. 2014. PMID: 24636337 Free PMC article. Clinical Trial.

3

Small molecule Mcl-1 inhibitors for the treatment of cancer.

Belmar J, Fesik SW. Belmar J, et al. Pharmacol Ther. 2015 Jan;145:76-84. doi: 10.1016/j.pharmthera.2014.08.003. Epub 2014 Aug 27. Pharmacol Ther. 2015. PMID: 25172548 Free PMC article. Review.

4

Design, synthesis, stereochemical determination, molecular docking study, in silico pre-ADMET prediction and anti-proliferative activities of indole-pyrimidine derivatives as Mcl-1 inhibitors.

Lamie PF, Philoppes JN. Lamie PF, et al. Bioorg Chem. 2021 Nov;116:105335. doi: 10.1016/j.bioorg.2021.105335. Epub 2021 Sep 6. Bioorg Chem. 2021. PMID: 34509795

5

Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.

Bruncko M, Wang L, Sheppard GS, Phillips DC, Tahir SK, Xue J, Erickson S, Fidanze S, Fry E, Hasvold L, Jenkins GJ, Jin S, Judge RA, Kovar PJ, Madar D, Nimmer P, Park C, Petros AM, Rosenberg SH, Smith ML, Song X, Sun C, Tao ZF, Wang X, Xiao Y, Zhang H, Tse C, Leverson JD, Elmore SW, Souers AJ. Bruncko M, et al. J Med Chem. 2015 Mar 12;58(5):2180-94. doi: 10.1021/jm501258m. Epub 2015 Feb 26. J Med Chem. 2015. PMID: 25679114

6

Design, Synthesis, and Structural Characterization of Lysine Covalent BH3 Peptides Targeting Mcl-1.

Gambini L, Udompholkul P, Baggio C, Muralidharan A, Kenjić N, Assar Z, Perry JJP, Pellecchia M. Gambini L, et al. J Med Chem. 2021 Apr 22;64(8):4903-4912. doi: 10.1021/acs.jmedchem.1c00005. Epub 2021 Apr 2. J Med Chem. 2021. PMID: 33797903 Free PMC article.

7

Antagonists of IAP proteins: novel anti-tumor agents.

Wan Y, Liu T, Hou X, Dun Y, Guan P, Fang H. Wan Y, et al. Curr Med Chem. 2014;21(34):3877-92. doi: 10.2174/0929867321666140826115258. Curr Med Chem. 2014. PMID: 25174926 Review.

8

DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis.

Milani M, Byrne DP, Greaves G, Butterworth M, Cohen GM, Eyers PA, Varadarajan S. Milani M, et al. Cell Death Dis. 2017 Jan 12;8(1):e2552. doi: 10.1038/cddis.2016.485. Cell Death Dis. 2017. PMID: 28079887 Free PMC article.

9

Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors.

Lee T, Bian Z, Zhao B, Hogdal LJ, Sensintaffar JL, Goodwin CM, Belmar J, Shaw S, Tarr JC, Veerasamy N, Matulis SM, Koss B, Fischer MA, Arnold AL, Camper DV, Browning CF, Rossanese OW, Budhraja A, Opferman J, Boise LH, Savona MR, Letai A, Olejniczak ET, Fesik SW. Lee T, et al. FEBS Lett. 2017 Jan;591(1):240-251. doi: 10.1002/1873-3468.12497. Epub 2016 Dec 19. FEBS Lett. 2017. PMID: 27878989 Free PMC article.

10

Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors.

Luan S, Ge Q, Chen Y, Dai M, Yang J, Li K, Liu D, Zhao L. Luan S, et al. Bioorg Med Chem Lett. 2017 May 1;27(9):1943-1948. doi: 10.1016/j.bmcl.2017.03.028. Epub 2017 Mar 16. Bioorg Med Chem Lett. 2017. PMID: 28343875

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