28096459 17268504 22798753 18624777 26059427 20421416 19716367 29915376 21861820 23359429 18491041 17921032 18220525 20190788 21232036 18538664 21717585 20442493 17082448 16920992 16696577 21253550 27020305 21156064 29477076 26328484 27038496 2212205 - Search Results

Year	Number of Results
2006	8
2007	10
2008	19
2009	7
2010	16
2011	7
2012	8
2013	7
2014	7
2015	5
2016	5
2017	4
2018	2
2019	1
2020	1
2021	1
2023	0

1

Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.

Gerber H, Wu F, Dimitrov M, Garcia Osuna GM, Fraering PC. Gerber H, et al. J Biol Chem. 2017 Mar 3;292(9):3751-3767. doi: 10.1074/jbc.M116.754101. Epub 2017 Jan 17. J Biol Chem. 2017. PMID: 28096459 Free PMC article.

2

When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease.

Wolfe MS. Wolfe MS. EMBO Rep. 2007 Feb;8(2):136-40. doi: 10.1038/sj.embor.7400896. EMBO Rep. 2007. PMID: 17268504 Free PMC article. Review.

3

Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's Disease.

Bulic B, Ness J, Hahn S, Rennhack A, Jumpertz T, Weggen S. Bulic B, et al. Curr Neuropharmacol. 2011 Dec;9(4):598-622. doi: 10.2174/157015911798376352. Curr Neuropharmacol. 2011. PMID: 22798753 Free PMC article.

4

Parenchymal and vascular Abeta-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease.

Thal DR, Griffin WS, Braak H. Thal DR, et al. J Cell Mol Med. 2008 Oct;12(5B):1848-62. doi: 10.1111/j.1582-4934.2008.00411.x. Epub 2008 Jul 10. J Cell Mol Med. 2008. PMID: 18624777 Free PMC article. Review.

5

Production of active glycosylation-deficient γ-secretase complex for crystallization studies.

López AR, Dimitrov M, Gerber H, Braman V, Hacker DL, Wurm FM, Fraering PC. López AR, et al. Biotechnol Bioeng. 2015 Dec;112(12):2516-26. doi: 10.1002/bit.25675. Epub 2015 Jul 14. Biotechnol Bioeng. 2015. PMID: 26059427

6

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.

Stempfle D, Kanwar R, Loewer A, Fortini ME, Merdes G. Stempfle D, et al. Mol Cell Biol. 2010 Jul;30(13):3165-75. doi: 10.1128/MCB.00030-10. Epub 2010 Apr 26. Mol Cell Biol. 2010. PMID: 20421416 Free PMC article.

7

Targeting Abeta and tau in Alzheimer's disease, an early interim report.

Golde TE, Petrucelli L, Lewis J. Golde TE, et al. Exp Neurol. 2010 Jun;223(2):252-66. doi: 10.1016/j.expneurol.2009.07.035. Epub 2009 Aug 27. Exp Neurol. 2010. PMID: 19716367 Free PMC article. Review.

8

A presenilin-1 mutation causes Alzheimer disease without affecting Notch signaling.

Zhang S, Cai F, Wu Y, Bozorgmehr T, Wang Z, Zhang S, Huang D, Guo J, Shen L, Rankin C, Tang B, Song W. Zhang S, et al. Mol Psychiatry. 2020 Mar;25(3):603-613. doi: 10.1038/s41380-018-0101-x. Epub 2018 Jun 18. Mol Psychiatry. 2020. PMID: 29915376

9

Alzheimer's disease: emerging trends in small molecule therapies.

Mohamed T, Rao PP. Mohamed T, et al. Curr Med Chem. 2011;18(28):4299-320. doi: 10.2174/092986711797200435. Curr Med Chem. 2011. PMID: 21861820 Review.

10

Highly efficient production of the Alzheimer's γ-secretase integral membrane protease complex by a multi-gene stable integration approach.

Alattia JR, Matasci M, Dimitrov M, Aeschbach L, Balasubramanian S, Hacker DL, Wurm FM, Fraering PC. Alattia JR, et al. Biotechnol Bioeng. 2013 Jul;110(7):1995-2005. doi: 10.1002/bit.24851. Epub 2013 Feb 15. Biotechnol Bioeng. 2013. PMID: 23359429

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