28710481 33581113 30592623 26396237 29308544 30670570 24981771 24874075 22952686 22204929 25288684 28202670 29513927 22988865 24957201 33706934 26758690 24947832 31583594 28289968 30858560 32247367 34050929 23754980 32853409 32848606 24850078 3443976 - Search Results

Year	Number of Results
2010	2
2011	11
2012	29
2013	11
2014	18
2015	8
2016	9
2017	9
2018	19
2019	16
2020	15
2021	14
2022	13
2023	1

1

The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions.

Carrion MDP, Marsicano S, Daniele F, Marte A, Pischedda F, Di Cairano E, Piovesana E, von Zweydorf F, Kremmer E, Gloeckner CJ, Onofri F, Perego C, Piccoli G. Carrion MDP, et al. Sci Rep. 2017 Jul 14;7(1):5377. doi: 10.1038/s41598-017-05760-9. Sci Rep. 2017. PMID: 28710481 Free PMC article.

2

The ubiquitin ligase Ariadne-1 regulates neurotransmitter release via ubiquitination of NSF.

Ramírez J, Morales M, Osinalde N, Martínez-Padrón I, Mayor U, Ferrús A. Ramírez J, et al. J Biol Chem. 2021 Jan-Jun;296:100408. doi: 10.1016/j.jbc.2021.100408. Epub 2021 Feb 11. J Biol Chem. 2021. PMID: 33581113 Free PMC article.

3

The Parkinson's disease-associated mutation N1437H impairs conformational dynamics in the G domain of LRRK2.

Huang X, Wu C, Park Y, Long X, Hoang QQ, Liao J. Huang X, et al. FASEB J. 2019 Apr;33(4):4814-4823. doi: 10.1096/fj.201802031R. Epub 2018 Dec 28. FASEB J. 2019. PMID: 30592623 Free PMC article.

4

LRRK2 autophosphorylation enhances its GTPase activity.

Liu Z, Mobley JA, DeLucas LJ, Kahn RA, West AB. Liu Z, et al. FASEB J. 2016 Jan;30(1):336-47. doi: 10.1096/fj.15-277095. Epub 2015 Sep 22. FASEB J. 2016. PMID: 26396237 Free PMC article.

5

The LRRK2 signalling system.

Price A, Manzoni C, Cookson MR, Lewis PA. Price A, et al. Cell Tissue Res. 2018 Jul;373(1):39-50. doi: 10.1007/s00441-017-2759-9. Epub 2018 Jan 8. Cell Tissue Res. 2018. PMID: 29308544 Free PMC article. Review.

6

Kinase activity of mutant LRRK2 manifests differently in hetero-dimeric vs. homo-dimeric complexes.

Leandrou E, Markidi E, Memou A, Melachroinou K, Greggio E, Rideout HJ. Leandrou E, et al. Biochem J. 2019 Feb 8;476(3):559-579. doi: 10.1042/BCJ20180589. Biochem J. 2019. PMID: 30670570

7

Genetic, structural, and molecular insights into the function of ras of complex proteins domains.

Civiero L, Dihanich S, Lewis PA, Greggio E. Civiero L, et al. Chem Biol. 2014 Jul 17;21(7):809-18. doi: 10.1016/j.chembiol.2014.05.010. Epub 2014 Jun 26. Chem Biol. 2014. PMID: 24981771 Free PMC article. Review.

8

Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration.

Plowey ED, Johnson JW, Steer E, Zhu W, Eisenberg DA, Valentino NM, Liu YJ, Chu CT. Plowey ED, et al. Biochim Biophys Acta. 2014 Sep;1842(9):1596-603. doi: 10.1016/j.bbadis.2014.05.016. Epub 2014 May 27. Biochim Biophys Acta. 2014. PMID: 24874075 Free PMC article.

9

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers.

Civiero L, Vancraenenbroeck R, Belluzzi E, Beilina A, Lobbestael E, Reyniers L, Gao F, Micetic I, De Maeyer M, Bubacco L, Baekelandt V, Cookson MR, Greggio E, Taymans JM. Civiero L, et al. PLoS One. 2012;7(8):e43472. doi: 10.1371/journal.pone.0043472. Epub 2012 Aug 29. PLoS One. 2012. PMID: 22952686 Free PMC article.

10

Regulation of physiologic actions of LRRK2: focus on autophagy.

Ferree A, Guillily M, Li H, Smith K, Takashima A, Squillace R, Weigele M, Collins JJ, Wolozin B. Ferree A, et al. Neurodegener Dis. 2012;10(1-4):238-41. doi: 10.1159/000332599. Epub 2011 Dec 23. Neurodegener Dis. 2012. PMID: 22204929 Free PMC article.

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