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Effects of 3'-(4-morpholinyl)-3'-deaminodaunorubicin,3'- (4-methoxy-1-piperidinyl)-3'-deaminodaunorubicin and daunorubicin on nuclear and polysomal RNA synthesis in human colon carcinoma cells in vitro.
Johnston JB, Begleiter A, Glazer RI. Johnston JB, et al. Cancer Lett. 1986 Nov;33(2):225-33. doi: 10.1016/0304-3835(86)90028-5. Cancer Lett. 1986. PMID: 3791193
The sugar amine modified anthracyclines, 3'-(4-morpholinyl)-3'-deaminodaunorubicin (MD) and 3'-(4-methoxy-1-piperidinyl)-3'-deaminodaunorubicin (MEO), are 10-fold more potent than daunorubicin (DAU) as inhibitors of RNA synthesis in human colon …
The sugar amine modified anthracyclines, 3'-(4-morpholinyl)-3'-deaminodaunorubicin (MD) and 3'-(4-methoxy …
Enhanced antitumor properties of 3'-(4-morpholinyl) and 3'-(4-methoxy-1-piperidinyl) derivatives of 3'-deaminodaunorubicin.
Mosher CW, Wu HY, Fujiwara AN, Acton EM. Mosher CW, et al. J Med Chem. 1982 Jan;25(1):18-24. doi: 10.1021/jm00343a004. J Med Chem. 1982. PMID: 7086816
Reductive N,N-dialkylation of daunorubicin with 2,2'-oxydiacetaldehyde and NaBH3CN occurred in two steps without interruption and with cyclization to form 3'-(4-morpholinyl)-3'-deaminodaunorubicin. This derivative retained the antitumor efficacy …
Reductive N,N-dialkylation of daunorubicin with 2,2'-oxydiacetaldehyde and NaBH3CN occurred in two steps without interruption and with cycli …