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Table representation of search results timeline featuring number of search results per year.

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1991 5
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Your search for 30. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase retrieved no results
BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease.
Moussa-Pacha NM, Abdin SM, Omar HA, Alniss H, Al-Tel TH. Moussa-Pacha NM, et al. Med Res Rev. 2020 Jan;40(1):339-384. doi: 10.1002/med.21622. Epub 2019 Jul 26. Med Res Rev. 2020. PMID: 31347728 Review.
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder with no current cure. One of the important therapeutic approaches of AD is the inhibition of beta-site APP cleaving enzyme-1 (BACE1), which is involved in the rat
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder with no current cure. One of
Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase.
Sun L, Zhou R, Yang G, Shi Y. Sun L, et al. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E476-E485. doi: 10.1073/pnas.1618657114. Epub 2016 Dec 5. Proc Natl Acad Sci U S A. 2017. PMID: 27930341 Free PMC article.
A hallmark of Alzheimer's disease (AD) is the aggregation of beta-amyloid peptides (Abeta) into amyloid plaques in patient brain. Cleavage of amyloid precursor protein (APP) by the intramembrane protease gamma-secr
A hallmark of Alzheimer's disease (AD) is the aggregation of beta-amyloid peptides (Abeta) into amyloi
Is It the Twilight of BACE1 Inhibitors?
Hrabinova M, Pejchal J, Kucera T, Jun D, Schmidt M, Soukup O. Hrabinova M, et al. Curr Neuropharmacol. 2021;19(1):61-77. doi: 10.2174/1570159X18666200503023323. Curr Neuropharmacol. 2021. PMID: 32359337 Free PMC article.
beta-secretase (BACE1) has been regarded as a prime target for the development of amyloid beta (Abeta) lowering drugs in the therapy of Alzheimers disease (AD). ...
beta-secretase (BACE1) has been regarded as a prime target for the development of amyloid beta (Abeta) lowering
BACE1 in Alzheimer's disease.
Sathya M, Premkumar P, Karthick C, Moorthi P, Jayachandran KS, Anusuyadevi M. Sathya M, et al. Clin Chim Acta. 2012 Dec 24;414:171-8. doi: 10.1016/j.cca.2012.08.013. Epub 2012 Aug 20. Clin Chim Acta. 2012. PMID: 22926063 Review.
Targeting BACE1 (beta-site APP cleaving enzyme 1 or beta-secretase) is the focus of Alzheimer's disease (AD) research because this aspartyl protease is involved in the abnormal production of beta amyloid plaques (Abeta), the …
Targeting BACE1 (beta-site APP cleaving enzyme 1 or beta-secretase) is the focus of Alzheimer's diseas
gamma-Secretase modulators.
Wolfe MS. Wolfe MS. Curr Alzheimer Res. 2007 Dec;4(5):571-3. doi: 10.2174/156720507783018299. Curr Alzheimer Res. 2007. PMID: 18220525 Review.
gamma-Secretase is responsible for the final cut of the amyloid beta-peptide (Abeta) precursor (APP) to produce the Abeta peptide implicated the pathogenesis of Alzheimer's disease (AD). ...Because proteolysis of Notch by gamma- …
gamma-Secretase is responsible for the final cut of the amyloid beta-peptide (Abeta) precursor (APP) to produce …
Repression of Alzheimer's beta-secretase.
Liao FF, Wang R, Park EA. Liao FF, et al. Aging (Albany NY). 2013 Nov;5(11):789-90. doi: 10.18632/aging.100612. Aging (Albany NY). 2013. PMID: 24177050 Free PMC article. No abstract available.
Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer's Disease.
Wolfe MS. Wolfe MS. Molecules. 2021 Jan 13;26(2):388. doi: 10.3390/molecules26020388. Molecules. 2021. PMID: 33450968 Free PMC article. Review.
Among these substrates, the amyloid precursor protein (APP) has been the most studied, as generation of aggregation-prone amyloid beta-protein (Abeta) is a defining feature of Alzheimer's disease (AD). ...Substrate-ba …
Among these substrates, the amyloid precursor protein (APP) has been the most studied, as generation of aggregation-pro …
Selective Secretase Targeting for Alzheimer's Disease Therapy.
Miranda A, Montiel E, Ulrich H, Paz C. Miranda A, et al. J Alzheimers Dis. 2021;81(1):1-17. doi: 10.3233/JAD-201027. J Alzheimers Dis. 2021. PMID: 33749645 Review.
Alzheimer's disease (AD) is associated with marked atrophy of the cerebral cortex and accumulation of amyloid plaques and neurofibrillary tangles. Amyloid plaques are formed by oligomers of amyloid-beta (Abeta) in the brain, with a
Alzheimer's disease (AD) is associated with marked atrophy of the cerebral cortex and accumulation of amyloid pl
Insight γ-Secretase: Structure, Function, and Role in Alzheimer's Disease.
Mal S, Malik U, Pal D, Mishra A. Mal S, et al. Curr Drug Targets. 2021;22(12):1376-1403. doi: 10.2174/1389450121999201230203709. Curr Drug Targets. 2021. PMID: 33390127 Review.
Gamma (gamma) secretase is an intra-membrane protease complex that cleaves the single-- pass transmembrane protein, the amyloid precursor protein, and Notch. ...Any mutation in presenilin-1 or the cleavage of amyloid precursor p
Gamma (gamma) secretase is an intra-membrane protease complex that cleaves the single-- pass transmembrane protein, the amy
Identification and biology of β-secretase.
Kandalepas PC, Vassar R. Kandalepas PC, et al. J Neurochem. 2012 Jan;120 Suppl 1:55-61. doi: 10.1111/j.1471-4159.2011.07512.x. Epub 2011 Nov 28. J Neurochem. 2012. PMID: 22122287 Free article. Review.
Our knowledge of the etiology of Alzheimer's disease (AD) has advanced tremendously since the discovery of amyloid beta (Abeta) aggregation in diseased brains. Accumulating evidence suggests that Abeta plays a causative role in AD. The beta
Our knowledge of the etiology of Alzheimer's disease (AD) has advanced tremendously since the discovery of amyloid
9,784 results