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Year Number of Results
1991 5
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2000 143
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Page 1
Showing results for 30. expression of a noncoding rna is elevated in alzheimer s disease and drive a rapid feed forward regulation or beta secretase
Your search for 30. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase retrieved no results
BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease.
Ghosh AK, Osswald HL. Ghosh AK, et al. Chem Soc Rev. 2014 Oct 7;43(19):6765-813. doi: 10.1039/c3cs60460h. Chem Soc Rev. 2014. PMID: 24691405 Free PMC article. Review.
BACE1 (beta-secretase, memapsin 2, Asp2) has emerged as a promising target for the treatment of Alzheimer's disease. ...BACE1 inhibition has direct implications in the Alzheimer's disease pathology without largely affecting …
BACE1 (beta-secretase, memapsin 2, Asp2) has emerged as a promising target for the treatment of Alzheimer's d …
BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease.
Moussa-Pacha NM, Abdin SM, Omar HA, Alniss H, Al-Tel TH. Moussa-Pacha NM, et al. Med Res Rev. 2020 Jan;40(1):339-384. doi: 10.1002/med.21622. Epub 2019 Jul 26. Med Res Rev. 2020. PMID: 31347728 Review.
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder with no current cure. One of the important therapeutic approaches of AD is the inhibition of beta-site APP cleaving enzyme-1 (BACE1), which is involved in the rat …
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder with no current cure. One of …
Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase.
Sun L, Zhou R, Yang G, Shi Y. Sun L, et al. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E476-E485. doi: 10.1073/pnas.1618657114. Epub 2016 Dec 5. Proc Natl Acad Sci U S A. 2017. PMID: 27930341 Free PMC article.
A hallmark of Alzheimer's disease (AD) is the aggregation of beta-amyloid peptides (Abeta) into amyloid plaques in patient brain. Cleavage of amyloid precursor protein (APP) by the intramembrane protease gamma-secr …
A hallmark of Alzheimer's disease (AD) is the aggregation of beta-amyloid peptides (Abeta) into amyloi …
BACE1: More than just a β-secretase.
Taylor HA, Przemylska L, Clavane EM, Meakin PJ. Taylor HA, et al. Obes Rev. 2022 Jul;23(7):e13430. doi: 10.1111/obr.13430. Epub 2022 Feb 4. Obes Rev. 2022. PMID: 35119166 Free PMC article. Review.
beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) research has historically focused on its actions as the beta-secretase responsible for the production of beta-amyloid beta, observed in Alzheimer' …
beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) research has historically focused on its actions a …
Repression of Alzheimer's beta-secretase.
Liao FF, Wang R, Park EA. Liao FF, et al. Aging (Albany NY). 2013 Nov;5(11):789-90. doi: 10.18632/aging.100612. Aging (Albany NY). 2013. PMID: 24177050 Free PMC article. No abstract available.
gamma-Secretase modulators.
Wolfe MS. Wolfe MS. Curr Alzheimer Res. 2007 Dec;4(5):571-3. doi: 10.2174/156720507783018299. Curr Alzheimer Res. 2007. PMID: 18220525 Review.
gamma-Secretase is responsible for the final cut of the amyloid beta-peptide (Abeta) precursor (APP) to produce the Abeta peptide implicated the pathogenesis of Alzheimer's disease (AD). ...Because proteolysis of Notch by gamma- …
gamma-Secretase is responsible for the final cut of the amyloid beta-peptide (Abeta) precursor (APP) to produce …
Post-translational regulation of the β-secretase BACE1.
Araki W. Araki W. Brain Res Bull. 2016 Sep;126(Pt 2):170-177. doi: 10.1016/j.brainresbull.2016.04.009. Epub 2016 Apr 13. Brain Res Bull. 2016. PMID: 27086128 Review.
beta-Secretase, widely known as beta-site APP cleaving enzyme 1 (BACE1), is a membrane-associated protease that cleaves amyloid precursor protein (APP) to generate amyloid beta-protein (Abeta). As this cleavage is a p …
beta-Secretase, widely known as beta-site APP cleaving enzyme 1 (BACE1), is a membrane-associated protease that cleaves …
Selective Secretase Targeting for Alzheimer's Disease Therapy.
Miranda A, Montiel E, Ulrich H, Paz C. Miranda A, et al. J Alzheimers Dis. 2021;81(1):1-17. doi: 10.3233/JAD-201027. J Alzheimers Dis. 2021. PMID: 33749645 Review.
Alzheimer's disease (AD) is associated with marked atrophy of the cerebral cortex and accumulation of amyloid plaques and neurofibrillary tangles. Amyloid plaques are formed by oligomers of amyloid-beta (Abeta) in the brain, with a …
Alzheimer's disease (AD) is associated with marked atrophy of the cerebral cortex and accumulation of amyloid pl …
BACE1 in Alzheimer's disease.
Sathya M, Premkumar P, Karthick C, Moorthi P, Jayachandran KS, Anusuyadevi M. Sathya M, et al. Clin Chim Acta. 2012 Dec 24;414:171-8. doi: 10.1016/j.cca.2012.08.013. Epub 2012 Aug 20. Clin Chim Acta. 2012. PMID: 22926063 Review.
Targeting BACE1 (beta-site APP cleaving enzyme 1 or beta-secretase) is the focus of Alzheimer's disease (AD) research because this aspartyl protease is involved in the abnormal production of beta amyloid plaques (Abeta), the …
Targeting BACE1 (beta-site APP cleaving enzyme 1 or beta-secretase) is the focus of Alzheimer's diseas …
Identification and biology of β-secretase.
Kandalepas PC, Vassar R. Kandalepas PC, et al. J Neurochem. 2012 Jan;120 Suppl 1:55-61. doi: 10.1111/j.1471-4159.2011.07512.x. Epub 2011 Nov 28. J Neurochem. 2012. PMID: 22122287 Free article. Review.
Our knowledge of the etiology of Alzheimer's disease (AD) has advanced tremendously since the discovery of amyloid beta (Abeta) aggregation in diseased brains. Accumulating evidence suggests that Abeta plays a causative role in AD. The beta …
Our knowledge of the etiology of Alzheimer's disease (AD) has advanced tremendously since the discovery of amyloid …
10,326 results
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