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10,886 results

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Showing results for 30. expression of a noncoding rna is elevated in alzheimer s disease and drive a rapid feed forward regulation or beta secretase
Your search for 30. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase retrieved no results
Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Abeta42 and Abeta40 peptides by gamma-secretase.
Sun L, Zhou R, Yang G, Shi Y. Sun L, et al. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E476-E485. doi: 10.1073/pnas.1618657114. Epub 2016 Dec 5. Proc Natl Acad Sci U S A. 2017. PMID: 27930341 Free PMC article.
A hallmark of Alzheimer's disease (AD) is the aggregation of beta-amyloid peptides (Abeta) into amyloid plaques in patient brain. Cleavage of amyloid precursor protein (APP) by the intramembrane protease gamma-secr …
A hallmark of Alzheimer's disease (AD) is the aggregation of beta-amyloid peptides (Abeta) into amyloi …
BACE1: More than just a beta-secretase.
Taylor HA, Przemylska L, Clavane EM, Meakin PJ. Taylor HA, et al. Obes Rev. 2022 Jul;23(7):e13430. doi: 10.1111/obr.13430. Epub 2022 Feb 4. Obes Rev. 2022. PMID: 35119166 Free PMC article. Review.
beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) research has historically focused on its actions as the beta-secretase responsible for the production of beta-amyloid beta, observed in Alzheimer' …
beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) research has historically focused on its actions a …
gamma-Secretase modulators.
Wolfe MS. Wolfe MS. Curr Alzheimer Res. 2007 Dec;4(5):571-3. doi: 10.2174/156720507783018299. Curr Alzheimer Res. 2007. PMID: 18220525 Review.
gamma-Secretase is responsible for the final cut of the amyloid beta-peptide (Abeta) precursor (APP) to produce the Abeta peptide implicated the pathogenesis of Alzheimer's disease (AD). ...Because proteolysis of Notch by gamma- …
gamma-Secretase is responsible for the final cut of the amyloid beta-peptide (Abeta) precursor (APP) to produce …
Selective Secretase Targeting for Alzheimer's Disease Therapy.
Miranda A, Montiel E, Ulrich H, Paz C. Miranda A, et al. J Alzheimers Dis. 2021;81(1):1-17. doi: 10.3233/JAD-201027. J Alzheimers Dis. 2021. PMID: 33749645 Review.
Alzheimer's disease (AD) is associated with marked atrophy of the cerebral cortex and accumulation of amyloid plaques and neurofibrillary tangles. Amyloid plaques are formed by oligomers of amyloid-beta (Abeta) in the brain, with a …
Alzheimer's disease (AD) is associated with marked atrophy of the cerebral cortex and accumulation of amyloid pl …
Cryo-EM structures of human gamma-secretase.
Yang G, Zhou R, Shi Y. Yang G, et al. Curr Opin Struct Biol. 2017 Oct;46:55-64. doi: 10.1016/j.sbi.2017.05.013. Epub 2017 Jul 17. Curr Opin Struct Biol. 2017. PMID: 28628788 Review.
gamma-secretase, a membrane-embedded aspartate protease, catalyzes peptide bond hydrolysis of a large variety of type I integral membrane proteins exemplified by amyloid precursor protein (APP). Cleavage of APP leads to formation of beta-amyl …
gamma-secretase, a membrane-embedded aspartate protease, catalyzes peptide bond hydrolysis of a large variety of type I integral memb …
Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2.
Lichtenthaler SF, Tschirner SK, Steiner H. Lichtenthaler SF, et al. Curr Opin Neurobiol. 2022 Feb;72:101-110. doi: 10.1016/j.conb.2021.09.003. Epub 2021 Oct 22. Curr Opin Neurobiol. 2022. PMID: 34689040 Review.
Secretases are a group of proteases that are major drug targets considered for the prevention and treatment of Alzheimer's disease (AD). Secretases do not only process the AD-linked neuronal amyloid precursor protein (APP) b …
Secretases are a group of proteases that are major drug targets considered for the prevention and treatment of Alzheimer's …
BACE1 in Alzheimer's disease.
Sathya M, Premkumar P, Karthick C, Moorthi P, Jayachandran KS, Anusuyadevi M. Sathya M, et al. Clin Chim Acta. 2012 Dec 24;414:171-8. doi: 10.1016/j.cca.2012.08.013. Epub 2012 Aug 20. Clin Chim Acta. 2012. PMID: 22926063 Review.
Targeting BACE1 (beta-site APP cleaving enzyme 1 or beta-secretase) is the focus of Alzheimer's disease (AD) research because this aspartyl protease is involved in the abnormal production of beta amyloid plaques (Abeta), the …
Targeting BACE1 (beta-site APP cleaving enzyme 1 or beta-secretase) is the focus of Alzheimer's diseas …
gamma-Secretase and its modulators: Twenty years and beyond.
Xia W. Xia W. Neurosci Lett. 2019 May 14;701:162-169. doi: 10.1016/j.neulet.2019.02.011. Epub 2019 Feb 11. Neurosci Lett. 2019. PMID: 30763650 Free PMC article. Review.
Twenty years ago, Wolfe, Xia, and Selkoe identified two aspartate residues in Alzheimer's presenilin protein that constitute the active site of the gamma-secretase complex. Mutations in the genes encoding amyloid precursor protein …
Twenty years ago, Wolfe, Xia, and Selkoe identified two aspartate residues in Alzheimer's presenilin protein that const …
10,886 results
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