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10,886 results

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Page 1
Your search for 30. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase retrieved no results
Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Abeta42 and Abeta40 peptides by gamma-secretase.
Sun L, Zhou R, Yang G, Shi Y. Sun L, et al. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E476-E485. doi: 10.1073/pnas.1618657114. Epub 2016 Dec 5. Proc Natl Acad Sci U S A. 2017. PMID: 27930341 Free PMC article.
A hallmark of Alzheimer's disease (AD) is the aggregation of beta-amyloid peptides (Abeta) into amyloid plaques in patient brain. Cleavage of amyloid precursor protein (APP) by the intramembrane protease gamma-secr
A hallmark of Alzheimer's disease (AD) is the aggregation of beta-amyloid peptides (Abeta) into amyloi
BACE1: More than just a beta-secretase.
Taylor HA, Przemylska L, Clavane EM, Meakin PJ. Taylor HA, et al. Obes Rev. 2022 Jul;23(7):e13430. doi: 10.1111/obr.13430. Epub 2022 Feb 4. Obes Rev. 2022. PMID: 35119166 Free PMC article. Review.
beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) research has historically focused on its actions as the beta-secretase responsible for the production of beta-amyloid beta, observed in Alzheimer'
beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) research has historically focused on its actions a
gamma-Secretase modulators.
Wolfe MS. Wolfe MS. Curr Alzheimer Res. 2007 Dec;4(5):571-3. doi: 10.2174/156720507783018299. Curr Alzheimer Res. 2007. PMID: 18220525 Review.
gamma-Secretase is responsible for the final cut of the amyloid beta-peptide (Abeta) precursor (APP) to produce the Abeta peptide implicated the pathogenesis of Alzheimer's disease (AD). ...Because proteolysis of Notch by gamma- …
gamma-Secretase is responsible for the final cut of the amyloid beta-peptide (Abeta) precursor (APP) to produce …
Selective Secretase Targeting for Alzheimer's Disease Therapy.
Miranda A, Montiel E, Ulrich H, Paz C. Miranda A, et al. J Alzheimers Dis. 2021;81(1):1-17. doi: 10.3233/JAD-201027. J Alzheimers Dis. 2021. PMID: 33749645 Review.
Alzheimer's disease (AD) is associated with marked atrophy of the cerebral cortex and accumulation of amyloid plaques and neurofibrillary tangles. Amyloid plaques are formed by oligomers of amyloid-beta (Abeta) in the brain, with a
Alzheimer's disease (AD) is associated with marked atrophy of the cerebral cortex and accumulation of amyloid pl
Cryo-EM structures of human gamma-secretase.
Yang G, Zhou R, Shi Y. Yang G, et al. Curr Opin Struct Biol. 2017 Oct;46:55-64. doi: 10.1016/j.sbi.2017.05.013. Epub 2017 Jul 17. Curr Opin Struct Biol. 2017. PMID: 28628788 Review.
gamma-secretase, a membrane-embedded aspartate protease, catalyzes peptide bond hydrolysis of a large variety of type I integral membrane proteins exemplified by amyloid precursor protein (APP). Cleavage of APP leads to formation of beta-amyl
gamma-secretase, a membrane-embedded aspartate protease, catalyzes peptide bond hydrolysis of a large variety of type I integral memb …
Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2.
Lichtenthaler SF, Tschirner SK, Steiner H. Lichtenthaler SF, et al. Curr Opin Neurobiol. 2022 Feb;72:101-110. doi: 10.1016/j.conb.2021.09.003. Epub 2021 Oct 22. Curr Opin Neurobiol. 2022. PMID: 34689040 Review.
Secretases are a group of proteases that are major drug targets considered for the prevention and treatment of Alzheimer's disease (AD). Secretases do not only process the AD-linked neuronal amyloid precursor protein (APP) b
Secretases are a group of proteases that are major drug targets considered for the prevention and treatment of Alzheimer's
BACE1 in Alzheimer's disease.
Sathya M, Premkumar P, Karthick C, Moorthi P, Jayachandran KS, Anusuyadevi M. Sathya M, et al. Clin Chim Acta. 2012 Dec 24;414:171-8. doi: 10.1016/j.cca.2012.08.013. Epub 2012 Aug 20. Clin Chim Acta. 2012. PMID: 22926063 Review.
Targeting BACE1 (beta-site APP cleaving enzyme 1 or beta-secretase) is the focus of Alzheimer's disease (AD) research because this aspartyl protease is involved in the abnormal production of beta amyloid plaques (Abeta), the …
Targeting BACE1 (beta-site APP cleaving enzyme 1 or beta-secretase) is the focus of Alzheimer's diseas
gamma-Secretase and its modulators: Twenty years and beyond.
Xia W. Xia W. Neurosci Lett. 2019 May 14;701:162-169. doi: 10.1016/j.neulet.2019.02.011. Epub 2019 Feb 11. Neurosci Lett. 2019. PMID: 30763650 Free PMC article. Review.
Twenty years ago, Wolfe, Xia, and Selkoe identified two aspartate residues in Alzheimer's presenilin protein that constitute the active site of the gamma-secretase complex. Mutations in the genes encoding amyloid precursor protein
Twenty years ago, Wolfe, Xia, and Selkoe identified two aspartate residues in Alzheimer's presenilin protein that const …
10,886 results
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