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1991 5
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2000 143
2001 174
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Your search for 30. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase retrieved no results
Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead.
Kumar D, Ganeshpurkar A, Kumar D, Modi G, Gupta SK, Singh SK. Kumar D, et al. Eur J Med Chem. 2018 Mar 25;148:436-452. doi: 10.1016/j.ejmech.2018.02.035. Epub 2018 Feb 15. Eur J Med Chem. 2018. PMID: 29477076 Review.
Alzheimer's disease (AD) is a neurodegenerative disease, characterized by progressive loss of memory which is associated with other cognitive deficits. ...There are various therapeutic interpolations under investigation to thwart and treat AD. Secre
Alzheimer's disease (AD) is a neurodegenerative disease, characterized by progressive loss of memory which is as
BACE1 (beta-secretase) inhibitors for the treatment of Alzheimer's disease.
Ghosh AK, Osswald HL. Ghosh AK, et al. Chem Soc Rev. 2014 Oct 7;43(19):6765-813. doi: 10.1039/c3cs60460h. Chem Soc Rev. 2014. PMID: 24691405 Free PMC article. Review.
BACE1 (beta-secretase, memapsin 2, Asp2) has emerged as a promising target for the treatment of Alzheimer's disease. ...BACE1 inhibition has direct implications in the Alzheimer's disease pathology without largely affecting …
BACE1 (beta-secretase, memapsin 2, Asp2) has emerged as a promising target for the treatment of Alzheimer's d
Structural basis of Notch recognition by human gamma-secretase.
Yang G, Zhou R, Zhou Q, Guo X, Yan C, Ke M, Lei J, Shi Y. Yang G, et al. Nature. 2019 Jan;565(7738):192-197. doi: 10.1038/s41586-018-0813-8. Epub 2018 Dec 31. Nature. 2019. PMID: 30598546
Aberrant cleavage of Notch by gamma-secretase leads to several types of cancer, but how gamma-secretase recognizes its substrate remains unknown. ...These features reveal the structural basis of Notch recognition and have implications for the recruitment of the a
Aberrant cleavage of Notch by gamma-secretase leads to several types of cancer, but how gamma-secretase recognizes its substra …
BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer's Disease Pathology.
Koelsch G. Koelsch G. Molecules. 2017 Oct 13;22(10):1723. doi: 10.3390/molecules22101723. Molecules. 2017. PMID: 29027981 Free PMC article. Review.
Alzheimer's disease (AD) is a fatal progressive neurodegenerative disorder characterized by increasing loss in memory, cognition, and function of daily living. ...BACE1 (beta-secretase 1) catalyzes the initial cleavage of the amyloid p
Alzheimer's disease (AD) is a fatal progressive neurodegenerative disorder characterized by increasing loss in memory,
Development and mechanism of gamma-secretase modulators for Alzheimer's disease.
Crump CJ, Johnson DS, Li YM. Crump CJ, et al. Biochemistry. 2013 May 14;52(19):3197-216. doi: 10.1021/bi400377p. Epub 2013 May 2. Biochemistry. 2013. PMID: 23614767 Free PMC article. Review.
gamma-Secretase is an aspartyl intramembranal protease composed of presenilin, Nicastrin, Aph1, and Pen2 with 19 transmembrane domains. gamma-Secretase cleaves the amyloid precursor proteins (APP) to release Abeta peptides that likely play a causative …
gamma-Secretase is an aspartyl intramembranal protease composed of presenilin, Nicastrin, Aph1, and Pen2 with 19 transmembrane domain …
Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Abeta42 and Abeta40 peptides by gamma-secretase.
Sun L, Zhou R, Yang G, Shi Y. Sun L, et al. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E476-E485. doi: 10.1073/pnas.1618657114. Epub 2016 Dec 5. Proc Natl Acad Sci U S A. 2017. PMID: 27930341 Free PMC article.
A hallmark of Alzheimer's disease (AD) is the aggregation of beta-amyloid peptides (Abeta) into amyloid plaques in patient brain. Cleavage of amyloid precursor protein (APP) by the intramembrane protease gamma-secr
A hallmark of Alzheimer's disease (AD) is the aggregation of beta-amyloid peptides (Abeta) into amyloi
Structure and Function of the gamma-Secretase Complex.
Wolfe MS. Wolfe MS. Biochemistry. 2019 Jul 9;58(27):2953-2966. doi: 10.1021/acs.biochem.9b00401. Epub 2019 Jun 25. Biochemistry. 2019. PMID: 31198028 Free PMC article.
Recently, however, advances in cryo-electron microscopy have led to the first detailed structures of the protease complex. Two new reports of structures of gamma-secretase bound to membrane protein substrates provide great insight into the nature of substrate recogn …
Recently, however, advances in cryo-electron microscopy have led to the first detailed structures of the protease complex. Two new reports o …
Specific Inhibition of beta-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein.
Ben Halima S, Mishra S, Raja KMP, Willem M, Baici A, Simons K, Brüstle O, Koch P, Haass C, Caflisch A, Rajendran L. Ben Halima S, et al. Cell Rep. 2016 Mar 8;14(9):2127-2141. doi: 10.1016/j.celrep.2016.01.076. Epub 2016 Feb 25. Cell Rep. 2016. PMID: 26923602 Free article.
AD is characterized by toxic beta-amyloid (Abeta) peptides produced by beta- and gamma-secretase-mediated cleavage of the amyloid precursor protein (APP). beta-secretase inhibitors reduce Abeta levels, but mechanism-b …
AD is characterized by toxic beta-amyloid (Abeta) peptides produced by beta- and gamma-secretase-mediated cleava …
BACE inhibition-dependent repair of Alzheimer's pathophysiology.
Keskin AD, Kekuš M, Adelsberger H, Neumann U, Shimshek DR, Song B, Zott B, Peng T, Förstl H, Staufenbiel M, Nelken I, Sakmann B, Konnerth A, Busche MA. Keskin AD, et al. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8631-8636. doi: 10.1073/pnas.1708106114. Epub 2017 Jul 24. Proc Natl Acad Sci U S A. 2017. PMID: 28739891 Free PMC article.
Amyloid-beta (Abeta) is thought to play an essential pathogenic role in Alzheimers disease (AD). A key enzyme involved in the generation of Abeta is the beta-secretase BACE, for which powerful inhibitors have been developed and are currently in
Amyloid-beta (Abeta) is thought to play an essential pathogenic role in Alzheimers disease (AD). A key enzyme involved
Identification of presenilin 1-selective gamma-secretase inhibitors with reconstituted gamma-secretase complexes.
Lee J, Song L, Terracina G, Bara T, Josien H, Asberom T, Sasikumar TK, Burnett DA, Clader J, Parker EM, Zhang L. Lee J, et al. Biochemistry. 2011 Jun 7;50(22):4973-80. doi: 10.1021/bi200026m. Epub 2011 May 13. Biochemistry. 2011. PMID: 21528914
Accumulation of the beta-amyloid (Abeta) peptides is one of the major pathologic hallmarks in the brains of Alzheimer's disease (AD) patients. Abeta is generated by sequential proteolytic cleavage of the amyloid precursor protei
Accumulation of the beta-amyloid (Abeta) peptides is one of the major pathologic hallmarks in the brains of Alzheimer' …
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