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Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H₁-antihistamines for insomnia.
Ravula SB, Yu J, Tran JA, Arellano M, Tucci FC, Moree WJ, Li BF, Petroski RE, Wen J, Malany S, Hoare SR, Madan A, Crowe PD, Beaton G. Ravula SB, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):421-6. doi: 10.1016/j.bmcl.2011.10.115. Epub 2011 Nov 15. Bioorg Med Chem Lett. 2012. PMID: 22153347
Benzimidazole: A Milestone in the Field of Medicinal Chemistry.
Vasava MS, Bhoi MN, Rathwa SK, Jethava DJ, Acharya PT, Patel DB, Patel HD. Vasava MS, et al. Mini Rev Med Chem. 2020;20(7):532-565. doi: 10.2174/1389557519666191122125453. Mini Rev Med Chem. 2020. PMID: 31755386 Review.
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