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Structure of the neurotensin receptor 1 in complex with β-arrestin 1.
Huang W, Masureel M, Qu Q, Janetzko J, Inoue A, Kato HE, Robertson MJ, Nguyen KC, Glenn JS, Skiniotis G, Kobilka BK. Huang W, et al. Nature. 2020 Mar;579(7798):303-308. doi: 10.1038/s41586-020-1953-1. Epub 2020 Jan 16. Nature. 2020. PMID: 31945771 Free PMC article.
Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.
Pinkerton AB, Peddibhotla S, Yamamoto F, Slosky LM, Bai Y, Maloney P, Hershberger P, Hedrick MP, Falter B, Ardecky RJ, Smith LH, Chung TDY, Jackson MR, Caron MG, Barak LS. Pinkerton AB, et al. J Med Chem. 2019 Sep 12;62(17):8357-8363. doi: 10.1021/acs.jmedchem.9b00340. Epub 2019 Aug 20. J Med Chem. 2019. PMID: 31390201 Free PMC article.
A complex structure of arrestin-2 bound to a G protein-coupled receptor.
Yin W, Li Z, Jin M, Yin YL, de Waal PW, Pal K, Yin Y, Gao X, He Y, Gao J, Wang X, Zhang Y, Zhou H, Melcher K, Jiang Y, Cong Y, Edward Zhou X, Yu X, Eric Xu H. Yin W, et al. Cell Res. 2019 Dec;29(12):971-983. doi: 10.1038/s41422-019-0256-2. Epub 2019 Nov 27. Cell Res. 2019. PMID: 31776446 Free PMC article.
Allostery in Drug Development.
Cheng X, Jiang H. Cheng X, et al. Adv Exp Med Biol. 2019;1163:1-23. doi: 10.1007/978-981-13-8719-7_1. Adv Exp Med Biol. 2019. PMID: 31707697 Review.
β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.
Slosky LM, Bai Y, Toth K, Ray C, Rochelle LK, Badea A, Chandrasekhar R, Pogorelov VM, Abraham DM, Atluri N, Peddibhotla S, Hedrick MP, Hershberger P, Maloney P, Yuan H, Li Z, Wetsel WC, Pinkerton AB, Barak LS, Caron MG. Slosky LM, et al. Cell. 2020 Jun 11;181(6):1364-1379.e14. doi: 10.1016/j.cell.2020.04.053. Epub 2020 May 28. Cell. 2020. PMID: 32470395 Free PMC article.
24 results