32736291 32560161 34145320 35453631 33636387 33298972 30645642 33741046 33057100 32103062 32612495 34004238 34548498 35599495 35805938 36085537 34897411 35642531 34551822 32641508 34419621 32247367 30837320 32601174 33600829 31149340 32550012 3313572 - Search Results

Year	Number of Results
2018	2
2019	3
2020	11
2021	12
2022	8
2023	0

1

Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice.

Korecka JA, Thomas R, Hinrich AJ, Moskites AM, Macbain ZK, Hallett PJ, Isacson O, Hastings ML. Korecka JA, et al. Mol Ther Nucleic Acids. 2020 Sep 4;21:623-635. doi: 10.1016/j.omtn.2020.06.027. Epub 2020 Jun 27. Mol Ther Nucleic Acids. 2020. PMID: 32736291 Free PMC article.

2

The Future of Targeted Gene-Based Treatment Strategies and Biomarkers in Parkinson's Disease.

Polissidis A, Petropoulou-Vathi L, Nakos-Bimpos M, Rideout HJ. Polissidis A, et al. Biomolecules. 2020 Jun 16;10(6):912. doi: 10.3390/biom10060912. Biomolecules. 2020. PMID: 32560161 Free PMC article. Review.

3

Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10.

Wang X, Negrou E, Maloney MT, Bondar VV, Andrews SV, Montalban M, Llapashtica C, Maciuca R, Nguyen H, Solanoy H, Arguello A, Przybyla L, Moerke NJ, Huntwork-Rodriguez S, Henry AG. Wang X, et al. Sci Rep. 2021 Jun 18;11(1):12900. doi: 10.1038/s41598-021-91943-4. Sci Rep. 2021. PMID: 34145320 Free PMC article.

4

Dopamine Transporter, PhosphoSerine129 α-Synuclein and α-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice.

Domenicale C, Mercatelli D, Albanese F, Novello S, Vincenzi F, Varani K, Morari M. Domenicale C, et al. Biomedicines. 2022 Apr 12;10(4):881. doi: 10.3390/biomedicines10040881. Biomedicines. 2022. PMID: 35453631 Free PMC article.

5

The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease.

De Miranda BR, Castro SL, Rocha EM, Bodle CR, Johnson KE, Greenamyre JT. De Miranda BR, et al. Neurobiol Dis. 2021 Jun;153:105312. doi: 10.1016/j.nbd.2021.105312. Epub 2021 Feb 23. Neurobiol Dis. 2021. PMID: 33636387 Free PMC article.

6

Exosome markers of LRRK2 kinase inhibition.

Wang S, Kelly K, Brotchie JM, Koprich JB, West AB. Wang S, et al. NPJ Parkinsons Dis. 2020 Nov 13;6(1):32. doi: 10.1038/s41531-020-00138-7. NPJ Parkinsons Dis. 2020. PMID: 33298972 Free PMC article.

7

LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia.

Kim J, Pajarillo E, Rizor A, Son DS, Lee J, Aschner M, Lee E. Kim J, et al. PLoS One. 2019 Jan 15;14(1):e0210248. doi: 10.1371/journal.pone.0210248. eCollection 2019. PLoS One. 2019. PMID: 30645642 Free PMC article.

8

Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo.

Kluss JH, Mazza MC, Li Y, Manzoni C, Lewis PA, Cookson MR, Mamais A. Kluss JH, et al. Mol Neurodegener. 2021 Mar 19;16(1):17. doi: 10.1186/s13024-021-00441-8. Mol Neurodegener. 2021. PMID: 33741046 Free PMC article.

9

Mitochondrial DNA damage as a potential biomarker of LRRK2 kinase activity in LRRK2 Parkinson's disease.

Gonzalez-Hunt CP, Thacker EA, Toste CM, Boularand S, Deprets S, Dubois L, Sanders LH. Gonzalez-Hunt CP, et al. Sci Rep. 2020 Oct 14;10(1):17293. doi: 10.1038/s41598-020-74195-6. Sci Rep. 2020. PMID: 33057100 Free PMC article.

10

In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common Marmosets.

Vermilyea SC, Babinski A, Tran N, To S, Guthrie S, Kluss JH, Schmidt JK, Wiepz GJ, Meyer MG, Murphy ME, Cookson MR, Emborg ME, Golos TG. Vermilyea SC, et al. Sci Rep. 2020 Feb 26;10(1):3447. doi: 10.1038/s41598-020-60273-2. Sci Rep. 2020. PMID: 32103062 Free PMC article.

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