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2020 12
2021 20
2022 21
2023 1
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Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration.
Vest RT, Chou CC, Zhang H, Haney MS, Li L, Laqtom NN, Chang B, Shuken S, Nguyen A, Yerra L, Yang AC, Green C, Tanga M, Abu-Remaileh M, Bassik MC, Frydman J, Luo J, Wyss-Coray T. Vest RT, et al. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2121609119. doi: 10.1073/pnas.2121609119. Epub 2022 Mar 8. Proc Natl Acad Sci U S A. 2022. PMID: 35259016 Free PMC article.
Lysosomal Potassium Channels.
Huang P, Xu M, Wu Y, Rizvi Syeda AK, Dong XP. Huang P, et al. Handb Exp Pharmacol. 2022 Jul 26. doi: 10.1007/164_2022_600. Online ahead of print. Handb Exp Pharmacol. 2022. PMID: 35879576
Cathepsin K is a potent disaggregase of α-synuclein fibrils.
McGlinchey RP, Lacy SM, Walker RL 3rd, Lee JC. McGlinchey RP, et al. Biochem Biophys Res Commun. 2020 Sep 3;529(4):1106-1111. doi: 10.1016/j.bbrc.2020.06.155. Epub 2020 Jul 31. Biochem Biophys Res Commun. 2020. PMID: 32819572 Free PMC article.
49 results