34816454 34636234 33340024 35159225 34536404 35163674 34218726 33527843 33755597 34502093 33801336 35269543 35534374 - Search Results

Year	Number of Results
2020	1
2021	9
2022	6

1

Slowing the loss of physical function in amyotrophic lateral sclerosis with edaravone: Post hoc analysis of ALSFRS-R item scores in pivotal study MCI186-19.

Brooks BR, Pioro EP, Katz J, Takahashi F, Takei K, Zhang J, Apple S. Brooks BR, et al. Muscle Nerve. 2022 Feb;65(2):180-186. doi: 10.1002/mus.27467. Epub 2021 Dec 10. Muscle Nerve. 2022. PMID: 34816454

2

Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function.

Collibee SE, Bergnes G, Chuang C, Ashcraft L, Gardina J, Garard M, Jamison CR, Lu K, Lu PP, Muci A, Romero A, Valkevich E, Wang W, Warrington J, Yao B, Durham N, Hartman J, Marquez A, Hinken A, Schaletzky J, Xu D, Hwee DT, Morgans D, Malik FI, Morgan BP. Collibee SE, et al. J Med Chem. 2021 Oct 28;64(20):14930-14941. doi: 10.1021/acs.jmedchem.1c01067. Epub 2021 Oct 12. J Med Chem. 2021. PMID: 34636234 Free article.

3

Improving clinical trial outcomes in amyotrophic lateral sclerosis.

Kiernan MC, Vucic S, Talbot K, McDermott CJ, Hardiman O, Shefner JM, Al-Chalabi A, Huynh W, Cudkowicz M, Talman P, Van den Berg LH, Dharmadasa T, Wicks P, Reilly C, Turner MR. Kiernan MC, et al. Nat Rev Neurol. 2021 Feb;17(2):104-118. doi: 10.1038/s41582-020-00434-z. Epub 2020 Dec 18. Nat Rev Neurol. 2021. PMID: 33340024 Free PMC article. Review.

4

Therapeutic Targets in Amyotrophic Lateral Sclerosis: Focus on Ion Channels and Skeletal Muscle.

Tarantino N, Canfora I, Camerino GM, Pierno S. Tarantino N, et al. Cells. 2022 Jan 25;11(3):415. doi: 10.3390/cells11030415. Cells. 2022. PMID: 35159225 Free PMC article. Review.

5

Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study): a randomised, double-blind, placebo-controlled phase 3 trial.

Cudkowicz M, Genge A, Maragakis N, Petri S, van den Berg L, Aho VV, Sarapohja T, Kuoppamäki M, Garratt C, Al-Chalabi A; REFALS investigators. Cudkowicz M, et al. Lancet Neurol. 2021 Oct;20(10):821-831. doi: 10.1016/S1474-4422(21)00242-8. Lancet Neurol. 2021. PMID: 34536404

6

Gene Transfer of Skeletal Muscle-Type Myosin Light Chain Kinase via Adeno-Associated Virus 6 Improves Muscle Functions in an Amyotrophic Lateral Sclerosis Mouse Model.

Oya R, Tsukamoto O, Hitsumoto T, Nakahara N, Okamoto C, Matsuoka K, Kato H, Inohara H, Takashima S. Oya R, et al. Int J Mol Sci. 2022 Feb 3;23(3):1747. doi: 10.3390/ijms23031747. Int J Mol Sci. 2022. PMID: 35163674 Free PMC article.

7

Prescription and acceptance of durable medical equipment in FORTITUDE-ALS, a study of reldesemtiv in ALS: post hoc analyses of a randomized, double-blind, placebo-controlled clinical trial.

Rudnicki SA, Andrews JA, Genge A, Jackson C, Lechtzin N, Miller TM, Cockroft BM, Malik FI, Meng L, Wei J, Wolff AA, Shefner JM; FORTITUDE-ALS STUDY GROUP. Rudnicki SA, et al. Amyotroph Lateral Scler Frontotemporal Degener. 2022 May;23(3-4):263-270. doi: 10.1080/21678421.2021.1946083. Epub 2021 Jul 5. Amyotroph Lateral Scler Frontotemporal Degener. 2022. PMID: 34218726 Clinical Trial.

8

An old friend who has overstayed their welcome: the ALSFRS-R total score as primary endpoint for ALS clinical trials.

van Eijk RPA, de Jongh AD, Nikolakopoulos S, McDermott CJ, Eijkemans MJC, Roes KCB, van den Berg LH. van Eijk RPA, et al. Amyotroph Lateral Scler Frontotemporal Degener. 2021 May;22(3-4):300-307. doi: 10.1080/21678421.2021.1879865. Epub 2021 Feb 2. Amyotroph Lateral Scler Frontotemporal Degener. 2021. PMID: 33527843 Free article.

9

Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium.

van de Locht M, Donkervoort S, de Winter JM, Conijn S, Begthel L, Kusters B, Mohassel P, Hu Y, Medne L, Quinn C, Moore SA, Foley AR, Seo G, Hwee DT, Malik FI, Irving T, Ma W, Granzier HL, Kamsteeg EJ, Immadisetty K, Kekenes-Huskey P, Pinto JR, Voermans N, Bönnemann CG, Ottenheijm CA. van de Locht M, et al. J Clin Invest. 2021 May 3;131(9):e145700. doi: 10.1172/JCI145700. J Clin Invest. 2021. PMID: 33755597 Free PMC article.

10

Troponin Variants in Congenital Myopathies: How They Affect Skeletal Muscle Mechanics.

van de Locht M, Borsboom TC, Winter JM, Ottenheijm CAC. van de Locht M, et al. Int J Mol Sci. 2021 Aug 25;22(17):9187. doi: 10.3390/ijms22179187. Int J Mol Sci. 2021. PMID: 34502093 Free PMC article. Review.

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