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Biased Agonism: Lessons from Studies of Opioid Receptor Agonists.
Kelly E, Conibear A, Henderson G. Kelly E, et al. Annu Rev Pharmacol Toxicol. 2023 Jan 20;63:491-515. doi: 10.1146/annurev-pharmtox-052120-091058. Epub 2022 Sep 28. Annu Rev Pharmacol Toxicol. 2023. PMID: 36170657 Free article. Review.
A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists.
Chambers DR, Sulima A, Luo D, Prisinzano TE, Goldberg A, Xie B, Shi L, Paronis CA, Bergman J, Nassehi N, Selley DE, Imler GH, Jacobson AE, Rice KC. Chambers DR, et al. Molecules. 2022 Sep 30;27(19):6455. doi: 10.3390/molecules27196455. Molecules. 2022. PMID: 36234992 Free PMC article.
Recent progress in assays for GPCR drug discovery.
Guo S, Zhao T, Yun Y, Xie X. Guo S, et al. Am J Physiol Cell Physiol. 2022 Aug 1;323(2):C583-C594. doi: 10.1152/ajpcell.00464.2021. Epub 2022 Jul 11. Am J Physiol Cell Physiol. 2022. PMID: 35816640 Review.
Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids.
Vidal-Torres A, Fernández-Pastor B, García M, Ayet E, Cabot A, Burgueño J, Monroy X, Aubel B, Codony X, Romero L, Pascual R, Serafini MT, Encina G, Almansa C, Zamanillo D, Merlos M, Vela JM. Vidal-Torres A, et al. Acta Pharm Sin B. 2023 Jan;13(1):82-99. doi: 10.1016/j.apsb.2022.09.018. Epub 2022 Sep 25. Acta Pharm Sin B. 2023. PMID: 36815042 Free PMC article.
16 results