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Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo.
Vecchio LM, Sullivan P, Dunn AR, Bermejo MK, Fu R, Masoud ST, Gregersen E, Urs NM, Nazari R, Jensen PH, Ramsey A, Goldstein DS, Miller GW, Salahpour A. Vecchio LM, et al. J Neurochem. 2021 Aug;158(4):960-979. doi: 10.1111/jnc.15432. Epub 2021 Jun 12. J Neurochem. 2021. PMID: 33991113 Free PMC article.
Too much for your own good: Excessive dopamine damages neurons and contributes to Parkinson's disease: An Editorial Highlight for "Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo".
Masato A, Bubacco L, Greggio E. Masato A, et al. J Neurochem. 2021 Aug;158(4):833-836. doi: 10.1111/jnc.15442. Epub 2021 Jun 28. J Neurochem. 2021. PMID: 34184261 Free article.