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Conformational changes in the catalytic region are responsible for heat-induced activation of hyperthermophilic homoserine dehydrogenase.

Kubota T, Kurihara E, Watanabe K, Ogata K, Kaneko R, Goto M, Ohshima T, Yoshimune K. Kubota T, et al. Commun Biol. 2022 Jul 14;5(1):704. doi: 10.1038/s42003-022-03656-7. Commun Biol. 2022. PMID: 35835834 Free PMC article.

Inhibition of homoserine dehydrogenase by formation of a cysteine-NAD covalent complex.

Ogata K, Yajima Y, Nakamura S, Kaneko R, Goto M, Ohshima T, Yoshimune K. Ogata K, et al. Sci Rep. 2018 Apr 10;8(1):5749. doi: 10.1038/s41598-018-24063-1. Sci Rep. 2018. PMID: 29636528 Free PMC article.

Structural insight into activation of homoserine dehydrogenase from the archaeon Sulfolobus tokodaii via reduction.

Tomonaga Y, Kaneko R, Goto M, Ohshima T, Yoshimune K. Tomonaga Y, et al. Biochem Biophys Rep. 2015 Jul 15;3:14-17. doi: 10.1016/j.bbrep.2015.07.006. eCollection 2015 Sep. Biochem Biophys Rep. 2015. PMID: 29124164 Free PMC article.

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