Fusion of an immunoglobulin variable gene and a T cell receptor constant gene in the chromosome 14 inversion associated with T cell tumors

Cell. 1985 Dec;43(3 Pt 2):705-13. doi: 10.1016/0092-8674(85)90243-0.

Abstract

An inversion of chromosome 14, inv(14)(q11,q32), is frequently observed in human T cell tumors; the cytogenetic breakpoints are of interest because the T cell receptor alpha-chain and immunoglobulin heavy chain genes reside on chromosome bands 14q11 and 14q32, respectively. We have investigated the structure of the alpha-chain genes in a T cell line harboring the chromosome 14 inversion. On the normal chromosome 14, a V alpha segment has rearranged nonproductively with a J alpha segment. In contrast, the inverted chromosome features an unprecedented rearrangement in which an immunoglobulin heavy chain variable gene segment (VH) on chromosome band 14q32 has joined with a J alpha segment from band 14q11. The VH-J alpha C alpha rearrangement is productive at the genomic level and therefore may encode a hybrid immunoglobulin/T cell receptor polypeptide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Base Sequence
  • Cell Line
  • Chromosome Inversion*
  • Chromosomes, Human, 13-15 / ultrastructure*
  • Humans
  • Immunoglobulin Heavy Chains / genetics*
  • Immunoglobulin J-Chains / genetics*
  • Immunoglobulin Variable Region / genetics*
  • Lymphoma / genetics*
  • Receptors, Antigen, T-Cell / genetics*
  • T-Lymphocytes

Substances

  • Immunoglobulin Heavy Chains
  • Immunoglobulin J-Chains
  • Immunoglobulin Variable Region
  • Receptors, Antigen, T-Cell

Associated data

  • GENBANK/M12070
  • GENBANK/M12071
  • GENBANK/M12072