MiR-7683-3p from M2-exosomes attenuated atherosclerosis by activating the PPARgamma-LXRalpha-ABCG1 pathway mediated cholesterol efflux of vascular smooth muscle cell derived foam cells.
Wang S, Lv Y, Wang X, Zhang Z, Li J, Pan TI, Yung MAC, Zhang F, Zhang H, Meng J, Lian H, Wen S, Hao X, Wang P, Zhang Q, He T, Zhang Y, Wang X, Song J, Cui Y.
Wang S, et al.
J Nanobiotechnology. 2025 Sep 29;23(1):618. doi: 10.1186/s12951-025-03690-7.
J Nanobiotechnology. 2025.
PMID: 41024154
Free PMC article.
Next, an in vitro foam cell model was used to assess the effect and mechanism of M2-exos on lipid metabolism in vascular smooth muscle cells by western blot, Oil red O staining and cell total cholesterol assays. RNA-seq and quantitative real-time PCR were employed t …
Next, an in vitro foam cell model was used to assess the effect and mechanism of M2-exos on lipid metabolism in vascular smooth muscle cells …