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Page 1
Reactivity, SCE induction and mutagenicity of benzyl chloride derivatives.
Hemminki K, Falck K, Linnainmaa K. Hemminki K, et al. J Appl Toxicol. 1983 Aug;3(4):203-7. doi: 10.1002/jat.2550030408. J Appl Toxicol. 1983. PMID: 6358331
Benzyl chloride, benzyl bromide, p-methylbenzyl chloride, and p-nitrobenzyl chloride were used to study chemical reactivity with 4-(p-nitrobenzyl)-pyridine (NBP), and with guanosine in vitro, in relation to mutagenic potency in S. typhimu …
Benzyl chloride, benzyl bromide, p-methylbenzyl chloride, and p-nitrobenzyl chloride were used to study chemical …
Toxic Mixtures in Time-The Sequence Makes the Poison.
Ashauer R, O'Connor I, Escher BI. Ashauer R, et al. Environ Sci Technol. 2017 Mar 7;51(5):3084-3092. doi: 10.1021/acs.est.6b06163. Epub 2017 Feb 17. Environ Sci Technol. 2017. PMID: 28177231 Free article.
We test this hypothesis with the freshwater crustacean Gammarus pulex and four toxicants that act on different targets (diazinon, propiconazole, 4,6-dinitro-o-cresol, 4-nitrobenzyl chloride). We found clearly different toxicity when the exposure order …
We test this hypothesis with the freshwater crustacean Gammarus pulex and four toxicants that act on different targets (diazinon, propiconaz …
Hydrolysis of S-aryl-cysteinylglycine conjugates catalyzed by porcine kidney cortex membrane dipeptidase.
Poon JC, Josephy PD. Poon JC, et al. Xenobiotica. 2012 Dec;42(12):1178-86. doi: 10.3109/00498254.2012.700427. Epub 2012 Jun 29. Xenobiotica. 2012. PMID: 22742779
The cysteinylglycine conjugates of 1-(chloromethyl)naphthalene, 4-nitrobenzyl chloride, and 1-chloro-2,4-dinitrobenzene were synthesized and HPLC separation methods for their quantitation were developed. ...
The cysteinylglycine conjugates of 1-(chloromethyl)naphthalene, 4-nitrobenzyl chloride, and 1-chloro-2,4-dinitro …
Reduction of benzyl halides by liver microsomes. Formation of 478 NM-absorbing sigma-alkyl-ferric cytochrome P-450 complexes.
Mansuy D, Fontecave M. Mansuy D, et al. Biochem Pharmacol. 1983 Jun 15;32(12):1871-9. doi: 10.1016/0006-2952(83)90052-7. Biochem Pharmacol. 1983. PMID: 6882464
The benzyl halides benzyl bromide and 4-nitrobenzyl chloride are reduced anaerobically by NADPH and rat liver microsomes to yield toluene and 4-nitrotoluene, respectively. ...Microsomal reductions of 4-nitrobenzyl chloride and benz …
The benzyl halides benzyl bromide and 4-nitrobenzyl chloride are reduced anaerobically by NADPH and rat liver microsome …
Effects of conserved Arg20, Glu74 and Asp77 on the structure and function of a tau class glutathione S-transferase in rice.
Yang X, Wu Z, Gao J. Yang X, et al. Plant Mol Biol. 2021 Mar;105(4-5):451-462. doi: 10.1007/s11103-020-01099-4. Epub 2021 Jan 2. Plant Mol Biol. 2021. PMID: 33387174
Interestingly, the mutant E74A exhibited a significant decrease in activity towards 7-chloro-4-nitrobenzo-2-oxa-1, 3-diazole, 1-chloro-2, 4-dinitrobenzene and 4-nitrobenzyl chloride, while its activity towards substrate cumene hydroperoxide rema …
Interestingly, the mutant E74A exhibited a significant decrease in activity towards 7-chloro-4-nitrobenzo-2-oxa-1, 3-diazole, 1-chlor …
Kinetic characterization of recombinant human glutathione transferase T1-1, a polymorphic detoxication enzyme.
Jemth P, Mannervik B. Jemth P, et al. Arch Biochem Biophys. 1997 Dec 15;348(2):247-54. doi: 10.1006/abbi.1997.0357. Arch Biochem Biophys. 1997. PMID: 9434735
Further, the enzyme is active with 4-nitrobenzyl chloride and 4-nitrophenethyl bromide, but shows no detectable activity with the more chemically reactive 1-chloro-2,4-dinitrobenzene. ...In contrast, kcat and kcat/K(m)electrophile display either …
Further, the enzyme is active with 4-nitrobenzyl chloride and 4-nitrophenethyl bromide, but shows no detectable …
Effects of Substrate-Binding Site Residues on the Biochemical Properties of a Tau Class Glutathione S-Transferase from Oryza sativa.
Yang X, Wei J, Wu Z, Gao J. Yang X, et al. Genes (Basel). 2019 Dec 24;11(1):25. doi: 10.3390/genes11010025. Genes (Basel). 2019. PMID: 31878175 Free PMC article.
The hydrophobic side chains of amino acids of the H-site contributed to enzyme activity toward 4-nitrobenzyl chloride but had an inhibitory effect on enzyme activity toward 1-chloro-2,4-dinitrobenzene and cumene hydroperoxide. Different amino acids of …
The hydrophobic side chains of amino acids of the H-site contributed to enzyme activity toward 4-nitrobenzyl chloride b …
Significance of xenobiotic metabolism for bioaccumulation kinetics of organic chemicals in Gammarus pulex.
Ashauer R, Hintermeister A, O'Connor I, Elumelu M, Hollender J, Escher BI. Ashauer R, et al. Environ Sci Technol. 2012 Mar 20;46(6):3498-508. doi: 10.1021/es204611h. Epub 2012 Feb 28. Environ Sci Technol. 2012. PMID: 22321051 Free PMC article.
Bioaccumulation kinetics vary greatly among organisms and chemicals; thus, we investigated the influence of biotransformation kinetics on bioaccumulation in a model aquatic invertebrate using fifteen (14)C-labeled organic xenobiotics from diverse chemical classes and physicochemi …
Bioaccumulation kinetics vary greatly among organisms and chemicals; thus, we investigated the influence of biotransformation kinetics on bi …
SeGSTo, a novel glutathione S-transferase from the beet armyworm (Spodoptera exigua), involved in detoxification and oxidative stress.
Xu P, Han N, Kang T, Zhan S, Lee KS, Jin BR, Li J, Wan H. Xu P, et al. Cell Stress Chaperones. 2016 Sep;21(5):805-16. doi: 10.1007/s12192-016-0705-5. Epub 2016 May 26. Cell Stress Chaperones. 2016. PMID: 27230212 Free PMC article.
Multiple amino acid sequence alignment analysis shows that the SeGSTo sequence is closely related to the class 4 GSTo of Bombyx mori BmGSTo4 (77 % protein sequence similarity). ...The recombinant SeGSTo was able to protect super-coiled DNA from damage in a metal-catalyzed …
Multiple amino acid sequence alignment analysis shows that the SeGSTo sequence is closely related to the class 4 GSTo of Bombyx mori …
Bioaccumulation kinetics of organic xenobiotic pollutants in the freshwater invertebrate Gammarus pulex modeled with prediction intervals.
Ashauer R, Caravatti I, Hintermeister A, Escher BI. Ashauer R, et al. Environ Toxicol Chem. 2010 Jul;29(7):1625-36. doi: 10.1002/etc.175. Environ Toxicol Chem. 2010. PMID: 20821614
Uptake and elimination rate constants, bioaccumulation factors, and elimination times in the freshwater arthropod Gammarus pulex were measured for 14 organic micropollutants covering a wide range of hydrophobicity (imidacloprid, aldicarb, ethylacrylate, 4,6-dinitro-o-creso …
Uptake and elimination rate constants, bioaccumulation factors, and elimination times in the freshwater arthropod Gammarus pulex were measur …
37 results