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Hypoxia-responsive folic acid conjugated glycol chitosan nanoparticle for enhanced tumor targeting treatment.
Jang EH, Shim MK, Kim GL, Kim S, Kang H, Kim JH. Jang EH, et al. Int J Pharm. 2020 Apr 30;580:119237. doi: 10.1016/j.ijpharm.2020.119237. Epub 2020 Mar 19. Int J Pharm. 2020. PMID: 32201251
This study describes the development of glycol chitosan nanoparticles, hydrophobically modified with 4-nitrobenzyl chloroformate and folic acid (FA), that can specifically release drugs under hypoxic conditions. ...
This study describes the development of glycol chitosan nanoparticles, hydrophobically modified with 4-nitrobenzyl chlorofo …
Nanocarriers responsive to a hypoxia gradient facilitate enhanced tumor penetration and improved anti-tumor efficacy.
Zhen J, Tian S, Liu Q, Zheng C, Zhang Z, Ding Y, An Y, Liu Y, Shi L. Zhen J, et al. Biomater Sci. 2019 Jul 1;7(7):2986-2995. doi: 10.1039/c9bm00461k. Epub 2019 May 20. Biomater Sci. 2019. PMID: 31106796
The nanocarrier was composed of a poly(caprolactone) core and a mixed shell of poly(ethylene glycol) (PEG) and 4-nitrobenzyl chloroformate (NBCF)-modified polylysine (PLL). During the blood circulation, the NBCF-modified PLL was shielded by the PEG, which gav …
The nanocarrier was composed of a poly(caprolactone) core and a mixed shell of poly(ethylene glycol) (PEG) and 4-nitrobenzyl …