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cis-4-decenoic acid provokes mitochondrial bioenergetic dysfunction in rat brain.
Schuck PF, Ferreira Gda C, Tahara EB, Klamt F, Kowaltowski AJ, Wajner M. Schuck PF, et al. Life Sci. 2010 Jul 31;87(5-6):139-46. doi: 10.1016/j.lfs.2010.05.019. Epub 2010 Jun 9. Life Sci. 2010. PMID: 20540954 Free article.
AIMS: In the present work we investigated the in vitro effect of cis-4-decenoic acid, the pathognomonic metabolite of medium-chain acyl-CoA dehydrogenase deficiency, on various parameters of bioenergetic homeostasis in rat brain mitochondria. ...The activitie …
AIMS: In the present work we investigated the in vitro effect of cis-4-decenoic acid, the pathognomonic metabolite of m …
Oxidative stress induction by cis-4-decenoic acid: relevance for MCAD deficiency.
Schuck PF, Ceolato PC, Ferreira GC, Tonin A, Leipnitz G, Dutra-Filho CS, Latini A, Wajner M. Schuck PF, et al. Free Radic Res. 2007 Nov;41(11):1261-72. doi: 10.1080/10715760701687109. Free Radic Res. 2007. PMID: 17987455
Patients affected by medium-chain acyl-CoA dehydrogenase deficiency (MCADD) suffer from acute episodes of encephalopathy whose underlying mechanisms are poorly known. The present work investigated the in vitro effect of cis-4-decenoic acid (cDA), which accumu …
Patients affected by medium-chain acyl-CoA dehydrogenase deficiency (MCADD) suffer from acute episodes of encephalopathy whose underlying me …
A marine-derived fatty acid targets the cell membrane of Gram-positive bacteria.
Upender I, Yoshida O, Schrecengost A, Ranson H, Wu Q, Rowley DC, Kishore S, Cywes C, Miller EL, Whalen KE. Upender I, et al. J Bacteriol. 2023 Nov 21;205(11):e0031023. doi: 10.1128/jb.00310-23. Epub 2023 Oct 31. J Bacteriol. 2023. PMID: 37905811 Free PMC article.
Here, we use bacterial cytological profiling to identify the mechanism of action of the monounsaturated fatty acid (Z)-13-methyltetra-4-decenoic acid isolated from the marine bacterium Olleya marilimosa with antibacterial effects against Gram-positive bacteri …
Here, we use bacterial cytological profiling to identify the mechanism of action of the monounsaturated fatty acid (Z)-13-methyltetra-4 …
cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca(2+) homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver: Possible implications for the pathogenesis of MCAD deficiency.
Amaral AU, Cecatto C, da Silva JC, Wajner A, Godoy KDS, Ribeiro RT, Wajner M. Amaral AU, et al. Biochim Biophys Acta. 2016 Sep;1857(9):1363-1372. doi: 10.1016/j.bbabio.2016.05.007. Epub 2016 May 27. Biochim Biophys Acta. 2016. PMID: 27240720 Free article.
Na+, K+ ATPase activity is markedly reduced by cis-4-decenoic acid in synaptic plasma membranes from cerebral cortex of rats.
de Assis DR, Maria RC, Ferreira GC, Schuck PF, Latini A, Dutra-Filho CS, Wannmacher CM, Wyse AT, Wajner M. de Assis DR, et al. Exp Neurol. 2006 Jan;197(1):143-9. doi: 10.1016/j.expneurol.2005.09.002. Epub 2005 Oct 3. Exp Neurol. 2006. PMID: 16203000
The objective of the present study was to investigate the in vitro effects of the other metabolites that accumulate in tissues of medium-chain acyl-CoA dehydrogenase (MCAD)-deficient patients, namely cis-4-decenoic acid (cDA), octanoylcarnitine (OC), hexanoyl …
The objective of the present study was to investigate the in vitro effects of the other metabolites that accumulate in tissues of medium-cha …
Identification of novel decenoic acids in heated butter.
Ito N, Wada S, Yamanaka Y, Takagaki H, Nakamura H. Ito N, et al. Biosci Biotechnol Biochem. 2005 Dec;69(12):2416-20. doi: 10.1271/bbb.69.2416. Biosci Biotechnol Biochem. 2005. PMID: 16377902 Free article.
Novel decenoic acids such as (E)-4-decenoic acid and (E)- and (Z)-5-,6-decenoic acid were detected as minor components in heated butter using GC and GC/MS. ...
Novel decenoic acids such as (E)-4-decenoic acid and (E)- and (Z)-5-,6-decenoic acid were detected as minor components …
Ferulic Acid Modulates Dysfunctional Metabolic Pathways and Purinergic Activities, While Stalling Redox Imbalance and Cholinergic Activities in Oxidative Brain Injury.
Salau VF, Erukainure OL, Ibeji CU, Olasehinde TA, Koorbanally NA, Islam MS. Salau VF, et al. Neurotox Res. 2020 Apr;37(4):944-955. doi: 10.1007/s12640-019-00099-7. Epub 2019 Aug 17. Neurotox Res. 2020. PMID: 31422569
LC-MS analysis of the metabolites revealed restoration of most depleted metabolites, with concomitant generation of dihydroferulic acid 4-O-glucuronide, diadenosine heptaphosphate, cis-4-decenoic acid, ganglioside GT3 (d18:0/23:0), phosphatidylinositol-3,4,5- …
LC-MS analysis of the metabolites revealed restoration of most depleted metabolites, with concomitant generation of dihydroferulic acid 4-O- …
28 results