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siRNA JNJ-73763989 decreases HBsAg and HDV RNA in NA-treated hepatitis D patients but may cause ALT flares.
Wedemeyer H, Gane E, Agarwal K, Tabak ÖF, Forns X, Akarca US, Morozov V, Aleman S, Buti M, Yilmaz G, Lampertico P, Jezorwski J, Kakuda TN, Bakala A, Pehlivanov N, Verbinnen T, Lenz O, Biermer M. Wedemeyer H, et al. J Hepatol. 2026 May 15:S0168-8278(26)00282-5. doi: 10.1016/j.jhep.2026.05.007. Online ahead of print. J Hepatol. 2026. PMID: 42142631 Free article.
An immunocompetent murine model of virus-elicited liver fibrosis and hepatocellular carcinoma.
Batista MN, Bordignon J, P Mosimann AL, Bobrowski T, Chen HA, Tobin-Xet G, Barrall EA, Prokhnevska N, Vaidya AB, Lewy T, Dinnon KH 3rd, Seifert LL, Zeck B, Quirk C, Ho YJ, Filliol A, Wolfisberg R, Jiang C, Cogliati B, Chiriboga L, Theise N, MacDonald MR, Kamphorst AO, Scheel TKH, Sheahan TP, Billerbeck E, Lowe SW, Rosenberg BR, Rice CM. Batista MN, et al. J Hepatol. 2026 Jun;84(6):1062-1076. doi: 10.1016/j.jhep.2026.02.020. Epub 2026 Mar 11. J Hepatol. 2026. PMID: 41825745 Free PMC article.
Macrophage-derived cathepsin B disrupts intestinal tight junctions through occludin degradation and promotes alcohol-associated liver disease.
Fondevila MF, Kreimeyer H, Hsu CL, Tamargo-Azpilicueta J, Day LZ, Gritsenko M, Attah K, Cabré N, Harberts A, Tonetti FR, Yang Y, Yamazaki T, Schöler D, Eguileor A, Blasio C, Meijnikman AS, Zhang X, Garcia-Carbonell R, Hook V, Zhou E, Sun Z, Jacobs JM, Turner JR, Llorente C, AlcHepNet Investigators, Glass CK, Stärkel P, Reinheckel T, Diaz-Moreno I, Gonzalez DJ, Schnabl B. Fondevila MF, et al. J Hepatol. 2026 Jun;84(6):1045-1061. doi: 10.1016/j.jhep.2026.01.013. Epub 2026 Feb 5. J Hepatol. 2026. PMID: 41654223 Free PMC article.
Impact of Fatigue on Patient-Reported Outcomes and Work Productivity in Chronic Hepatitis B and C: Insights From a Multinational Registry Study.
Yilmaz Y, Yu ML, Alswat K, El-Kassas M, Ferret MB, Papatheodoridis G, Fernandez M, Eguchi Y, Duseja A, Keklikkiran Ç, Hamid S, Chan WK, Gordon SC, Esmat G, Isakov V, Roberts S, Méndez-Sánchez N, Fan JG, Gomez MR, George J, Singal AK, Ahmed A, Lam B, Nader F, Henry L, Stepanova M, AlQahtani S, Younossi ZM; Global Liver Council. Yilmaz Y, et al. J Viral Hepat. 2026 Jun;33(6):e70188. doi: 10.1111/jvh.70188. J Viral Hepat. 2026. PMID: 42144799
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