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1936 3
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1947 63
1948 54
1949 54
1950 146
1951 122
1952 132
1953 165
1954 149
1955 170
1956 145
1957 195
1958 168
1959 130
1960 112
1961 72
1962 84
1963 178
1964 308
1965 531
1966 769
1967 819
1968 1020
1969 1073
1970 1315
1971 1338
1972 1574
1973 1574
1974 1635
1975 2747
1976 2836
1977 2669
1978 2558
1979 2846
1980 3207
1981 3440
1982 3909
1983 4255
1984 4743
1985 5370
1986 5597
1987 5747
1988 6324
1989 7184
1990 7848
1991 7904
1992 8183
1993 8230
1994 8431
1995 8642
1996 8538
1997 8724
1998 8962
1999 8976
2000 9420
2001 9996
2002 10311
2003 10804
2004 11407
2005 12508
2006 12850
2007 13709
2008 14088
2009 14778
2010 15950
2011 16406
2012 16843
2013 17492
2014 17699
2015 17781
2016 16711
2017 16530
2018 16361
2019 16753
2020 17604
2021 16718
2022 17595
2023 16561
2024 16996
2025 18368
2026 14026
2027 17

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521,157 results

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The following term was ignored: "
The following term was not found in PubMed: DI+Digoxigenin-3-O-rutin+hyperthyroidism+insulin+serum
Page 1
LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.
Nakamura S, Shigeyama S, Minami S, Shima T, Akayama S, Matsuda T, Esposito A, Napolitano G, Kuma A, Namba-Hamano T, Nakamura J, Yamamoto K, Sasai M, Tokumura A, Miyamoto M, Oe Y, Fujita T, Terawaki S, Takahashi A, Hamasaki M, Yamamoto M, Okada Y, Komatsu M, Nagai T, Takabatake Y, Xu H, Isaka Y, Ballabio A, Yoshimori T. Nakamura S, et al. Nat Cell Biol. 2020 Oct;22(10):1252-1263. doi: 10.1038/s41556-020-00583-9. Epub 2020 Sep 28. Nat Cell Biol. 2020. PMID: 32989250
Here we show that transcription factor EB (TFEB)-a master transcriptional regulator of lysosomal biogenesis and autophagy-is activated during the lysosomal damage response, and its activation is dependent on the function of the ATG conjugation system, which mediates LC3 lipida …
Here we show that transcription factor EB (TFEB)-a master transcriptional regulator of lysosomal biogenesis and autophagy-is activated durin …
Crystallization of membrane proteins.
Ostermeier C, Michel H. Ostermeier C, et al. Curr Opin Struct Biol. 1997 Oct;7(5):697-701. doi: 10.1016/s0959-440x(97)80080-2. Curr Opin Struct Biol. 1997. PMID: 9345629 Free article. Review.
Variation of the size of the detergent micelle and/or increasing the size of the polar surface of the membrane protein is the most important route to well-ordered membrane protein crystals. The use of bicontinuous lipidic cubic phases also appears to be promising....
Variation of the size of the detergent micelle and/or increasing the size of the polar surface of the membrane protein is the most important …
N-Terminal Lipidation of Buforin II Generates a Potent and Stable Peptide Antibiotic.
Shi Y, Chen H, Chen S, Kong X, Liu Z, Wu S, Li X, Zheng K, Xu Y, Hu H. Shi Y, et al. J Med Chem. 2025 Aug 28;68(16):17624-17637. doi: 10.1021/acs.jmedchem.5c01258. Epub 2025 Aug 13. J Med Chem. 2025. PMID: 40799174
Considering its helix-hinge-helix structure, lipidations were performed on its N-terminal, generating 5 different analogs. By screening the antibacterial and hemolytic activities, BUFT-2C8 with branched octanoic acid tails was identified as the optimal candidate. .. …
Considering its helix-hinge-helix structure, lipidations were performed on its N-terminal, generating 5 different analogs. By …
Coarse-Grained Molecular Dynamics of pH-Sensitive Lipids.
Lado-Touriño I, Cerpa-Naranjo A. Lado-Touriño I, et al. Int J Mol Sci. 2023 Feb 27;24(5):4632. doi: 10.3390/ijms24054632. Int J Mol Sci. 2023. PMID: 36902063 Free PMC article.
In order to explore such systems, we used a MARTINI-derived forcefield, previously parameterized using all-atom simulation results. We calculated the average area per lipid, the second-rank order parameter and the lipid diffusion coefficient of both lipid bil …
In order to explore such systems, we used a MARTINI-derived forcefield, previously parameterized using all-atom simulation results. We calcu …
Anatomy of CD1-lipid antigen complexes.
Moody DB, Zajonc DM, Wilson IA. Moody DB, et al. Nat Rev Immunol. 2005 May;5(5):387-99. doi: 10.1038/nri1605. Nat Rev Immunol. 2005. PMID: 15864273 Review.
CD1 proteins bind lipids to form antigen complexes that contact T-cell receptors and activate T cells. Recent crystal structures of CD1 proteins show that their antigen-binding grooves are composed of up to four pockets (A', C', F' and T') and two antigen portals (C' and F …
CD1 proteins bind lipids to form antigen complexes that contact T-cell receptors and activate T cells. Recent crystal structures of C …
Lipid-based mesophases as matrices for nanoscale reactions.
Salvati Manni L, Fong WK, Mezzenga R. Salvati Manni L, et al. Nanoscale Horiz. 2020 Jun 1;5(6):914-927. doi: 10.1039/d0nh00079e. Epub 2020 Apr 23. Nanoscale Horiz. 2020. PMID: 32322863 Review.
Lipidic mesophases are versatile bioorganic materials that have been effectively employed as nanoscale matrices for membrane protein crystallization, drug delivery and as food emulsifiers over the last 30 years. In this review, the focus is upon studies that have employed …
Lipidic mesophases are versatile bioorganic materials that have been effectively employed as nanoscale matrices for membrane protein …
[Biochemical analysis of epidermal lipids].
Martini MC. Martini MC. Pathol Biol (Paris). 2003 Jul;51(5):267-70. doi: 10.1016/s0369-8114(03)00072-5. Pathol Biol (Paris). 2003. PMID: 14567192 Review. French.
According to the knowledge acquired some 15 years ago, the cutaneous lipids may be classified into 2 families: the "neutral" lipids, represented by cholesterol, cholesterol esters, cholesterol sulphate, triglycerides, free fatty acids, squalen and alcanes, and the " …
According to the knowledge acquired some 15 years ago, the cutaneous lipids may be classified into 2 families: the "neutral" lipid …
Chromatographic study of nucleoside-lipids by RP-UHPLC-DAD/CAD.
Ferey L, Slabi SA, Roy CE, Barthelemy P, Gaudin K. Ferey L, et al. Anal Bioanal Chem. 2018 Nov;410(29):7711-7721. doi: 10.1007/s00216-018-1388-9. Epub 2018 Sep 28. Anal Bioanal Chem. 2018. PMID: 30267273
Today, one of the most popular strategies in drug delivery is the encapsulation of therapeutic agents in supramolecular nanosystems formed from amphiphilic molecules. Synthetic nucleoside-lipids, composed of one nucleoside and lipidic chains, constitute promising ne …
Today, one of the most popular strategies in drug delivery is the encapsulation of therapeutic agents in supramolecular nanosystems formed f …
Post-translational modifications and stress adaptation: the paradigm of FKBP51.
Rein T. Rein T. Biochem Soc Trans. 2020 Apr 29;48(2):441-449. doi: 10.1042/BST20190332. Biochem Soc Trans. 2020. PMID: 32318709 Free PMC article. Review.
This mini-review discusses the role of FKBP51 in the function of proteins responsible for setting the phosphorylation, ubiquitination and lipidation of other proteins. Examples include the kinases Akt1, CDK5 and GSK3beta, the phosphatases calcineurin, PP2A and PHLPP, and t …
This mini-review discusses the role of FKBP51 in the function of proteins responsible for setting the phosphorylation, ubiquitination and …
521,157 results
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