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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1962 2
1964 1
1969 1
1973 2
1974 1
1975 1
1976 4
1977 3
1978 6
1979 8
1980 11
1981 16
1982 19
1983 29
1984 22
1985 20
1986 23
1987 18
1988 21
1989 16
1990 11
1991 17
1992 8
1993 15
1994 11
1995 9
1996 17
1997 11
1998 10
1999 7
2000 9
2001 11
2002 16
2003 9
2004 21
2005 26
2006 23
2007 21
2008 17
2009 26
2010 29
2011 32
2012 35
2013 24
2014 22
2015 26
2016 26
2017 28
2018 19
2019 28
2020 42
2021 25
2022 29
2023 4
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830 results
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Page 1
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Mavrakis KJ, McDonald ER 3rd, Schlabach MR, Billy E, Hoffman GR, deWeck A, Ruddy DA, Venkatesan K, Yu J, McAllister G, Stump M, deBeaumont R, Ho S, Yue Y, Liu Y, Yan-Neale Y, Yang G, Lin F, Yin H, Gao H, Kipp DR, Zhao S, McNamara JT, Sprague ER, Zheng B, Lin Y, Cho YS, Gu J, Crawford K, Ciccone D, Vitari AC, Lai A, Capka V, Hurov K, Porter JA, Tallarico J, Mickanin C, Lees E, Pagliarini R, Keen N, Schmelzle T, Hofmann F, Stegmeier F, Sellers WR. Mavrakis KJ, et al. Science. 2016 Mar 11;351(6278):1208-13. doi: 10.1126/science.aad5944. Epub 2016 Feb 11. Science. 2016. PMID: 26912361
5-Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage pathway. ...By interrogating data from a large-scale short hairpin RNA-mediated screen across 390 cancer cell line models, we found that the viability of MTAP-deficient cancer cells
5-Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage pathway. ...By interrogating data from a
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.
Kryukov GV, Wilson FH, Ruth JR, Paulk J, Tsherniak A, Marlow SE, Vazquez F, Weir BA, Fitzgerald ME, Tanaka M, Bielski CM, Scott JM, Dennis C, Cowley GS, Boehm JS, Root DE, Golub TR, Clish CB, Bradner JE, Hahn WC, Garraway LA. Kryukov GV, et al. Science. 2016 Mar 11;351(6278):1214-8. doi: 10.1126/science.aad5214. Epub 2016 Feb 11. Science. 2016. PMID: 26912360 Free PMC article.
Integrating data from comprehensive genomic profiling of cancer cell lines and from functional characterization of cancer cell dependencies, we discovered that loss of the enzyme methylthioadenosine phosphorylase (MTAP) confers a selective dependence on protein arginine me …
Integrating data from comprehensive genomic profiling of cancer cell lines and from functional characterization of cancer cell dependencies, …
Methylthioadenosine.
Avila MA, García-Trevijano ER, Lu SC, Corrales FJ, Mato JM. Avila MA, et al. Int J Biochem Cell Biol. 2004 Nov;36(11):2125-30. doi: 10.1016/j.biocel.2003.11.016. Int J Biochem Cell Biol. 2004. PMID: 15313459 Free article. Review.
5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues. ...This compound is metabolized solely by MTA-phosphorylase, to yield 5-methylthioribose-1-phosphate and adenine, a crucial step in the methio
5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues. ...This c
Methylthioadenosine.
Schlenk F. Schlenk F. Adv Enzymol Relat Areas Mol Biol. 1983;54:195-265. doi: 10.1002/9780470122990.ch4. Adv Enzymol Relat Areas Mol Biol. 1983. PMID: 6405586 Review. No abstract available.
5'-Methylthioadenosine and Cancer: old molecules, new understanding.
Li Y, Wang Y, Wu P. Li Y, et al. J Cancer. 2019 Jan 29;10(4):927-936. doi: 10.7150/jca.27160. eCollection 2019. J Cancer. 2019. PMID: 30854099 Free PMC article. Review.
While the metabolic changes in cancer tissues were first observed by Warburg Otto almost a century ago, altered metabolism has recently returned as a focus of cancer research. 5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside found i …
While the metabolic changes in cancer tissues were first observed by Warburg Otto almost a century ago, altered metabolism has recently retu …
Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine.
Barekatain Y, Ackroyd JJ, Yan VC, Khadka S, Wang L, Chen KC, Poral AH, Tran T, Georgiou DK, Arthur K, Lin YH, Satani N, Ballato ES, Behr EI, deCarvalho AC, Verhaak RGW, de Groot J, Huse JT, Asara JM, Kalluri R, Muller FL. Barekatain Y, et al. Nat Commun. 2021 Jul 9;12(1):4228. doi: 10.1038/s41467-021-24240-3. Nat Commun. 2021. PMID: 34244484 Free PMC article.
Homozygous deletion of methylthioadenosine phosphorylase (MTAP) in cancers such as glioblastoma represents a potentially targetable vulnerability. Homozygous MTAP-deleted cell lines in culture show elevation of MTAP's substrate metabolite, methylthioadenosine (MTA). …
Homozygous deletion of methylthioadenosine phosphorylase (MTAP) in cancers such as glioblastoma represents a potentially targetable v …
Serum and Amniotic Fluid Metabolic Profile Changes in Response to Gestational Diabetes Mellitus and the Association with Maternal-Fetal Outcomes.
Zhou Y, Zhao R, Lyu Y, Shi H, Ye W, Tan Y, Li R, Xu Y. Zhou Y, et al. Nutrients. 2021 Oct 18;13(10):3644. doi: 10.3390/nu13103644. Nutrients. 2021. PMID: 34684645 Free PMC article.
These shared differential metabolites were implicated in several metabolism pathways, including choline, tryptophan, histidine, and nicotinate and nicotinamide metabolism, and among them, N1-methyl-4-pyridone-3-carboxamide, 5'-methylthioadenosine, and kynurenic acid …
These shared differential metabolites were implicated in several metabolism pathways, including choline, tryptophan, histidine, and nicotina …
Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis.
Namanja-Magliano HA, Evans GB, Harijan RK, Tyler PC, Schramm VL. Namanja-Magliano HA, et al. Biochemistry. 2017 Sep 26;56(38):5090-5098. doi: 10.1021/acs.biochem.7b00576. Epub 2017 Sep 7. Biochemistry. 2017. PMID: 28836767 Free PMC article.
Mycobacterium tuberculosis 5'-deoxyadenosine/5'-methylthioadenosine nucleosidase (Rv0091) catalyzes the N-riboside hydrolysis of its substrates 5'-methylthioadenosine (MTA) and 5'-deoxyadenosine (5'-dAdo). 5'-dAdo is the pre …
Mycobacterium tuberculosis 5'-deoxyadenosine/5'-methylthioadenosine nucleosidase (Rv0091) catalyzes the N-riboside hydr …
Exploiting methionine restriction for cancer treatment.
Chaturvedi S, Hoffman RM, Bertino JR. Chaturvedi S, et al. Biochem Pharmacol. 2018 Aug;154:170-173. doi: 10.1016/j.bcp.2018.05.003. Epub 2018 May 4. Biochem Pharmacol. 2018. PMID: 29733806 Review.
Normal cells can synthesize sufficient methionine for growth requirements from homocysteine and 5-methyltetrahydrofolate and vitamin B12. However, many cancer-cell types require exogenous methionine for survival and therefore methionine restriction is a promising avenue fo …
Normal cells can synthesize sufficient methionine for growth requirements from homocysteine and 5-methyltetrahydrofolate and vitamin …
Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers.
Smith CR, Aranda R, Bobinski TP, Briere DM, Burns AC, Christensen JG, Clarine J, Engstrom LD, Gunn RJ, Ivetac A, Jean-Baptiste R, Ketcham JM, Kobayashi M, Kuehler J, Kulyk S, Lawson JD, Moya K, Olson P, Rahbaek L, Thomas NC, Wang X, Waters LM, Marx MA. Smith CR, et al. J Med Chem. 2022 Feb 10;65(3):1749-1766. doi: 10.1021/acs.jmedchem.1c01900. Epub 2022 Jan 18. J Med Chem. 2022. PMID: 35041419 Free article.
830 results